Lehne's Pharmacology for Nursing
Care
12th Edition
• Author(s)Jacqueline Rosenjack
Burchum; Laura D. Rosenthal
,TEST BANK
Question 1 – Multiple Choice (MCQ)
Clinical Scenario
A newly licensed nurse is preparing medications for several
patients. During orientation, the nurse asks why two patients
receiving the same dose of the same medication experience
different therapeutic effects.
Question Stem
Which factor best explains why patients may respond
differently to the same medication?
Answer Options
A. Every medication produces identical effects regardless of
patient characteristics.
B. Drug response is influenced by individual patient factors
affecting pharmacokinetics and pharmacodynamics.
C. Drug effectiveness depends solely on the medication dose.
D. Therapeutic effects are determined only by the
manufacturer's formulation.
,Correct Answer
B. Drug response is influenced by individual patient factors
affecting pharmacokinetics and pharmacodynamics.
Detailed Rationale
Patient responses vary because numerous physiologic, genetic,
developmental, environmental, and disease-related factors alter
how drugs are absorbed, distributed, metabolized, excreted,
and interact with receptors. Age, liver function, kidney function,
body composition, concurrent illnesses, genetics, and drug
interactions all contribute to variability in therapeutic response.
Understanding this variability enables nurses to individualize
medication monitoring, recognize unexpected responses early,
and improve medication safety.
Incorrect Option Analysis
Option A
Why Incorrect
Drug responses vary considerably among individuals.
Common Misconception
Identical prescriptions always produce identical outcomes.
, Medication Safety Risk
Failure to recognize toxicity or treatment failure.
Nursing Consideration
Assess each patient's response independently.
Option C
Why Incorrect
Dose is only one determinant of response.
Common Misconception
Higher doses automatically improve effectiveness.
Medication Safety Risk
Overdosing and adverse drug reactions.
Nursing Consideration
Evaluate patient-specific variables before medication
administration.
Option D
Why Incorrect
Manufacturing standards promote consistency, but patient
physiology primarily determines response.
Care
12th Edition
• Author(s)Jacqueline Rosenjack
Burchum; Laura D. Rosenthal
,TEST BANK
Question 1 – Multiple Choice (MCQ)
Clinical Scenario
A newly licensed nurse is preparing medications for several
patients. During orientation, the nurse asks why two patients
receiving the same dose of the same medication experience
different therapeutic effects.
Question Stem
Which factor best explains why patients may respond
differently to the same medication?
Answer Options
A. Every medication produces identical effects regardless of
patient characteristics.
B. Drug response is influenced by individual patient factors
affecting pharmacokinetics and pharmacodynamics.
C. Drug effectiveness depends solely on the medication dose.
D. Therapeutic effects are determined only by the
manufacturer's formulation.
,Correct Answer
B. Drug response is influenced by individual patient factors
affecting pharmacokinetics and pharmacodynamics.
Detailed Rationale
Patient responses vary because numerous physiologic, genetic,
developmental, environmental, and disease-related factors alter
how drugs are absorbed, distributed, metabolized, excreted,
and interact with receptors. Age, liver function, kidney function,
body composition, concurrent illnesses, genetics, and drug
interactions all contribute to variability in therapeutic response.
Understanding this variability enables nurses to individualize
medication monitoring, recognize unexpected responses early,
and improve medication safety.
Incorrect Option Analysis
Option A
Why Incorrect
Drug responses vary considerably among individuals.
Common Misconception
Identical prescriptions always produce identical outcomes.
, Medication Safety Risk
Failure to recognize toxicity or treatment failure.
Nursing Consideration
Assess each patient's response independently.
Option C
Why Incorrect
Dose is only one determinant of response.
Common Misconception
Higher doses automatically improve effectiveness.
Medication Safety Risk
Overdosing and adverse drug reactions.
Nursing Consideration
Evaluate patient-specific variables before medication
administration.
Option D
Why Incorrect
Manufacturing standards promote consistency, but patient
physiology primarily determines response.
