Karch’s Focus on Nursing
Pharmacology
9th Edition
Author(s)Rebecca G. Tucker
TEST BANK
NCLEX-RN Pharmacology Question Bank
Karch's Focus on Nursing Pharmacology (9th Edition)
Part 1: Introduction to Nursing Pharmacology
Chapter 1: Introduction to Drugs
Question 1
Clinical Scenario
,A nursing student is discussing drug development with a patient
enrolled in a research study. The patient asks why the
medication is first tested in animals before humans.
Question
Which statement best describes the primary purpose of
preclinical testing?
Options
A. To determine the drug's marketability and cost-effectiveness
B. To evaluate basic safety, toxicity, and biologic activity before
human studies
C. To compare the drug with all currently available medications
D. To establish final prescribing guidelines for healthcare
providers
Correct Answer
B. To evaluate basic safety, toxicity, and biologic activity before
human studies
Rationale
Preclinical testing occurs before human trials and typically
involves laboratory and animal studies. Researchers assess
,toxicity, pharmacologic effects, and potential therapeutic
benefits to determine whether a drug is sufficiently safe to
proceed to human testing.
Medication safety begins during preclinical evaluation because
severe toxic effects can be identified before exposing humans to
risk.
Why the Other Options Are Incorrect
A: Marketability is not the focus of preclinical testing.
C: Comparative effectiveness studies occur later in
development.
D: Prescribing guidelines are developed after extensive
clinical trials and regulatory review.
Learning Objective
Explain the purpose of preclinical drug testing.
Bloom's Taxonomy
Understand
Difficulty
Easy
NCLEX Client Needs Category
, Pharmacological and Parenteral Therapies
NCJMM Clinical Judgment Skill
Recognize Cues
Question 2
Clinical Scenario
A healthy volunteer participates in a first-in-human clinical trial
of an investigational medication.
Question
The nurse understands that the primary goal of a Phase I study
is to:
Options
A. Determine effectiveness in large patient populations
B. Compare the drug with standard therapy
C. Evaluate safety, dosage range, and pharmacokinetics in
humans
D. Monitor long-term adverse effects after approval
Correct Answer
Pharmacology
9th Edition
Author(s)Rebecca G. Tucker
TEST BANK
NCLEX-RN Pharmacology Question Bank
Karch's Focus on Nursing Pharmacology (9th Edition)
Part 1: Introduction to Nursing Pharmacology
Chapter 1: Introduction to Drugs
Question 1
Clinical Scenario
,A nursing student is discussing drug development with a patient
enrolled in a research study. The patient asks why the
medication is first tested in animals before humans.
Question
Which statement best describes the primary purpose of
preclinical testing?
Options
A. To determine the drug's marketability and cost-effectiveness
B. To evaluate basic safety, toxicity, and biologic activity before
human studies
C. To compare the drug with all currently available medications
D. To establish final prescribing guidelines for healthcare
providers
Correct Answer
B. To evaluate basic safety, toxicity, and biologic activity before
human studies
Rationale
Preclinical testing occurs before human trials and typically
involves laboratory and animal studies. Researchers assess
,toxicity, pharmacologic effects, and potential therapeutic
benefits to determine whether a drug is sufficiently safe to
proceed to human testing.
Medication safety begins during preclinical evaluation because
severe toxic effects can be identified before exposing humans to
risk.
Why the Other Options Are Incorrect
A: Marketability is not the focus of preclinical testing.
C: Comparative effectiveness studies occur later in
development.
D: Prescribing guidelines are developed after extensive
clinical trials and regulatory review.
Learning Objective
Explain the purpose of preclinical drug testing.
Bloom's Taxonomy
Understand
Difficulty
Easy
NCLEX Client Needs Category
, Pharmacological and Parenteral Therapies
NCJMM Clinical Judgment Skill
Recognize Cues
Question 2
Clinical Scenario
A healthy volunteer participates in a first-in-human clinical trial
of an investigational medication.
Question
The nurse understands that the primary goal of a Phase I study
is to:
Options
A. Determine effectiveness in large patient populations
B. Compare the drug with standard therapy
C. Evaluate safety, dosage range, and pharmacokinetics in
humans
D. Monitor long-term adverse effects after approval
Correct Answer
