APEA PRINCIPLES OF PHARMACOLOGY EXAM
APEA PRINCIPLES OF PHARMACOLOGY EXAM
QUESTIONS AND ANSWERS GRADED A+
Pharmacokinetics is:
A. The effect the drug has on the body.
B. The adverse response of the drug on the body.
C. The effect the body has on the drug.
D. The clinical formulation of the drug - correct answer C. The effect the
body has on the drug.
Absorption, distribution, metabolism, excretion
The ratio of minimum effective concentration (MEC) to minimum toxic
concentration (MTC) of a drug is the: - correct answer therapeutic window
,APEA PRINCIPLES OF PHARMACOLOGY EXAM
half life: - correct answer the time it takes for the plasma concentration of
the drug to be reduced to half of its original value
Drug clearance formula - correct answer rate of drug elimination / plasma
concentration of the drug
steady state - correct answer when the rate of drug input equals the rate
of drug elimination
Which of the following actions triggers a rise in membrane or action
potential of a cell?
A. Opening of the voltage gated sodium ions
B. Closure of voltage gated sodium ions
C. Opening of calcium ion channel
D. Opening of potassium voltage gated channels - correct answer A.
Opening of the voltage gated sodium ions
Before stimulation, a cell has a slightly negative electric charge
(compared with ECF). Outside is more positively charged. When
stimulus is encountered, sodium ion channel opens and sodium rushes
into the cell, causing depolarization (rise in membrane/action potential)
The process by which a drug's activity is altered in order to prepare it
for excretion: - correct answer biotransformation
, APEA PRINCIPLES OF PHARMACOLOGY EXAM
The amino acid found in dairy products, fish, and eggs is tyrosine. The
amino acid from which tyrosine is made is: - correct answer phenylalanine.
People take tyrosine to help manage depression, ADD, ADHD,
narcolepsy, and to improve alertness following sleep deprivation
The correct order of the transmission of a neurotransmitter is
presynaptic preparation followed by: - correct answer arrival of action
potential, release of transmitter, receptor interaction, and the
termination of transmitter action
In the pharmacokinetics of a drug, the rate of metabolism: - correct answer
varies widely between patients, influenced by genetic and environment
factors-->major reason for differences in plasma concentration of some
drugs after a standard dose, leading to a wide variation in drug
response
Metabolism: - correct answer process by which drugs are chemically
changes from a lipid-soluble form suitable for absorption and
distribution to a more water-soluble form that is suitable for excretion
The protein-bound part of a drug is: - correct answer Inactive and acts as a
reservoir
APEA PRINCIPLES OF PHARMACOLOGY EXAM
QUESTIONS AND ANSWERS GRADED A+
Pharmacokinetics is:
A. The effect the drug has on the body.
B. The adverse response of the drug on the body.
C. The effect the body has on the drug.
D. The clinical formulation of the drug - correct answer C. The effect the
body has on the drug.
Absorption, distribution, metabolism, excretion
The ratio of minimum effective concentration (MEC) to minimum toxic
concentration (MTC) of a drug is the: - correct answer therapeutic window
,APEA PRINCIPLES OF PHARMACOLOGY EXAM
half life: - correct answer the time it takes for the plasma concentration of
the drug to be reduced to half of its original value
Drug clearance formula - correct answer rate of drug elimination / plasma
concentration of the drug
steady state - correct answer when the rate of drug input equals the rate
of drug elimination
Which of the following actions triggers a rise in membrane or action
potential of a cell?
A. Opening of the voltage gated sodium ions
B. Closure of voltage gated sodium ions
C. Opening of calcium ion channel
D. Opening of potassium voltage gated channels - correct answer A.
Opening of the voltage gated sodium ions
Before stimulation, a cell has a slightly negative electric charge
(compared with ECF). Outside is more positively charged. When
stimulus is encountered, sodium ion channel opens and sodium rushes
into the cell, causing depolarization (rise in membrane/action potential)
The process by which a drug's activity is altered in order to prepare it
for excretion: - correct answer biotransformation
, APEA PRINCIPLES OF PHARMACOLOGY EXAM
The amino acid found in dairy products, fish, and eggs is tyrosine. The
amino acid from which tyrosine is made is: - correct answer phenylalanine.
People take tyrosine to help manage depression, ADD, ADHD,
narcolepsy, and to improve alertness following sleep deprivation
The correct order of the transmission of a neurotransmitter is
presynaptic preparation followed by: - correct answer arrival of action
potential, release of transmitter, receptor interaction, and the
termination of transmitter action
In the pharmacokinetics of a drug, the rate of metabolism: - correct answer
varies widely between patients, influenced by genetic and environment
factors-->major reason for differences in plasma concentration of some
drugs after a standard dose, leading to a wide variation in drug
response
Metabolism: - correct answer process by which drugs are chemically
changes from a lipid-soluble form suitable for absorption and
distribution to a more water-soluble form that is suitable for excretion
The protein-bound part of a drug is: - correct answer Inactive and acts as a
reservoir
