LEHNE PHARM 005 ADVERSE DRUG REACTIONS &
MEDICATION ERRORS EXAM 100+ QUESTION AND
ANSWERS WITH UPGRADED RATIONALES 2025-2026
VERSION A+ GRADED.
1. An adverse drug reaction (ADR) is best defined as:
A. Any medication error
B. A harmful, unintended response to a drug at normal doses
C. Drug abuse
D. Therapeutic failure
Answer: B
An ADR occurs when a drug produces an unwanted and harmful effect despite
being used appropriately at normal therapeutic doses.
2. Which type of ADR is generally predictable from the drug's known
pharmacologic action?
A. Type B
B. Type C
C. Type A
D. Type D
Answer: C
Type A reactions are dose-related and predictable based on the drug's mechanism
of action.
3. A Type B adverse drug reaction is typically:
A. Dose dependent
B. Predictable
C. Related to pharmacologic action
D. Unpredictable
Answer: D
,Type B reactions are bizarre, uncommon, and not predictable from known
pharmacology.
4. Which patient is at highest risk for experiencing an ADR?
A. Healthy young adult taking one medication
B. Adult receiving short-term therapy
C. Older adult taking multiple medications
D. Adolescent receiving topical medication
Answer: C
Advanced age and polypharmacy significantly increase ADR risk.
5. Polypharmacy is commonly defined as:
A. Use of one medication
B. Use of multiple medications simultaneously
C. Use of OTC drugs only
D. Use of herbal products only
Answer: B
Taking multiple medications increases the chance of interactions and adverse
reactions.
6. Which organ is most commonly involved in drug metabolism?
A. Kidney
B. Heart
C. Liver
D. Lung
Answer: C
The liver contains major enzyme systems responsible for drug metabolism.
7. Drug-induced hepatotoxicity primarily affects the:
A. Pancreas
B. Liver
, C. Spleen
D. Thyroid
Answer: B
Hepatotoxicity refers to toxic injury of the liver caused by medications.
8. An allergic drug reaction is classified as:
A. Type A
B. Type C
C. Type B
D. Type E
Answer: C
Drug allergies are immune-mediated and generally fall under Type B reactions.
9. Which manifestation may indicate anaphylaxis?
A. Dry mouth
B. Mild headache
C. Bronchospasm and hypotension
D. Constipation
Answer: C
Anaphylaxis is a life-threatening allergic reaction involving airway compromise
and cardiovascular collapse.
10.The most appropriate first-line treatment for anaphylaxis is:
A. Acetaminophen
B. Epinephrine
C. Diphenhydramine alone
D. Ibuprofen
Answer: B
Epinephrine rapidly reverses airway swelling, hypotension, and bronchospasm.
11.Which adverse effect is commonly associated with opioid therapy?
A. Hypertension
MEDICATION ERRORS EXAM 100+ QUESTION AND
ANSWERS WITH UPGRADED RATIONALES 2025-2026
VERSION A+ GRADED.
1. An adverse drug reaction (ADR) is best defined as:
A. Any medication error
B. A harmful, unintended response to a drug at normal doses
C. Drug abuse
D. Therapeutic failure
Answer: B
An ADR occurs when a drug produces an unwanted and harmful effect despite
being used appropriately at normal therapeutic doses.
2. Which type of ADR is generally predictable from the drug's known
pharmacologic action?
A. Type B
B. Type C
C. Type A
D. Type D
Answer: C
Type A reactions are dose-related and predictable based on the drug's mechanism
of action.
3. A Type B adverse drug reaction is typically:
A. Dose dependent
B. Predictable
C. Related to pharmacologic action
D. Unpredictable
Answer: D
,Type B reactions are bizarre, uncommon, and not predictable from known
pharmacology.
4. Which patient is at highest risk for experiencing an ADR?
A. Healthy young adult taking one medication
B. Adult receiving short-term therapy
C. Older adult taking multiple medications
D. Adolescent receiving topical medication
Answer: C
Advanced age and polypharmacy significantly increase ADR risk.
5. Polypharmacy is commonly defined as:
A. Use of one medication
B. Use of multiple medications simultaneously
C. Use of OTC drugs only
D. Use of herbal products only
Answer: B
Taking multiple medications increases the chance of interactions and adverse
reactions.
6. Which organ is most commonly involved in drug metabolism?
A. Kidney
B. Heart
C. Liver
D. Lung
Answer: C
The liver contains major enzyme systems responsible for drug metabolism.
7. Drug-induced hepatotoxicity primarily affects the:
A. Pancreas
B. Liver
, C. Spleen
D. Thyroid
Answer: B
Hepatotoxicity refers to toxic injury of the liver caused by medications.
8. An allergic drug reaction is classified as:
A. Type A
B. Type C
C. Type B
D. Type E
Answer: C
Drug allergies are immune-mediated and generally fall under Type B reactions.
9. Which manifestation may indicate anaphylaxis?
A. Dry mouth
B. Mild headache
C. Bronchospasm and hypotension
D. Constipation
Answer: C
Anaphylaxis is a life-threatening allergic reaction involving airway compromise
and cardiovascular collapse.
10.The most appropriate first-line treatment for anaphylaxis is:
A. Acetaminophen
B. Epinephrine
C. Diphenhydramine alone
D. Ibuprofen
Answer: B
Epinephrine rapidly reverses airway swelling, hypotension, and bronchospasm.
11.Which adverse effect is commonly associated with opioid therapy?
A. Hypertension
