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COMSAE Phase 2 Form 110: Questions & Answers 2026 update

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Pass your COMSAE Phase 2 (COMLEX Level 2) exam with these practice questions and correct answers. Master clinical cases, diagnosis, treatment, and osteopathic medical board prep.COMSAE Phase 2, COMLEX Level 2, Osteopathic exam prep, Medical board practice, COMSAE 110, COMLEX study guide, Medical school exam, Clinical case questions, DO board prep, Osteopathic medicine, COMSAE practice test, COMLEX Level 2 CE, Medical licensing exam, Board prep questions, Medical student study

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COMSAE PHASE 2 FORM 110 — v v v v v




PRACTICE EXAM QUESTIONS AND CORRECT ANSWERS (V
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ERIFIED ANSWERS) PLUS RATIONALES 2026/2027 Q&A | I v v v v v v v




NSTANT DOWNLOAD PDF v v




1.

vA 56-year- v


old man presents with substernal chest pain that began 1 hour ago while he was m
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owing the lawn. The pain is pressure-
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like and radiates to the left arm. ECG shows ST elevation in leads II, III, and aVF. Nex
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t best step in management?
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 A. Give sublingual nitroglycerin
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 B. Administer aspirin and activate cardiac catheterization lab
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 C. Start IV heparin only
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 D. Order a chest X-ray
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Answer: B. Administer aspirin and activate cardiac catheterization lab
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ST elevation in II, III, aVF = inferior STEMI. Reperfusion therapy is required (PCI if a
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vailable). Aspirin reduces mortality. Chest X-
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ray is not appropriate initially, and nitro is supportive but not definitive.
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2.

A 25-year-
v


old woman presents with fever, dysuria, and flank pain. Urinalysis shows WBC casts
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. Best treatment?
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 A. Oral nitrofurantoin
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 B. IV ceftriaxone
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 C. Oral ciprofloxacin
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 D. IV vancomycin
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,Answer: B. IV ceftriaxone
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WBC casts indicate pyelonephritis. Inpatient IV therapy (ceftriaxone) is indicated for
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systemic symptoms. Nitrofurantoin is for simple cystitis, not pyelo.
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3.

A 60-year-
v


old man with chronic alcohol use presents with confusion, ataxia, and ophthalmopl
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egia. Which vitamin deficiency is most likely?
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 A. Vitamin B1 (thiamine)
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 B. Vitamin B6 (pyridoxine)
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 C. Vitamin B12 (cobalamin)
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 D. Vitamin C
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Answer: A. Vitamin B1 (thiamine)
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Classic Wernicke encephalopathy triad: confusion, ataxia, ophthalmoplegia → thia
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mine deficiency.
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4.

A 32-year-
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old woman presents with fatigue, weight gain, constipation, and dry skin. TSH is ele
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vated. Best treatment?
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 A. Methimazole
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 B. Levothyroxine
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 C. Radioactive iodine
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 D. Propranolol
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Answer: B. Levothyroxine
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Primary hypothyroidism (high TSH). Levothyroxine is standard treatment.
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5.

,A 7-year-old boy has a sore throat, fever, and sandpaper-
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like rash. Rapid strep antigen test is positive. Best treatment?
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 A. Amoxicillin v




 B. Azithromycin v




 C. Ciprofloxacinv




 D. Supportive care only
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Answer: A. Amoxicillin v v


Scarlet fever is caused by Group A strep. Treat with penicillin or amoxicillin.
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6.

A 19-year-
v


old male presents after a motorcycle accident. He is hypotensive, has distended nec
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k veins, and tracheal deviation to the left. Best initial management?
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 A. Endotracheal intubation
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 B. Needle thoracostomy
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 C. Chest tube placement
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 D. IV fluids v v




Answer: B. Needle thoracostomy
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Tension pneumothorax → immediate decompression with needle thoracostomy, fol
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lowed by chest tube.
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7.

A 72-year-
v


old man has a resting tremor, bradykinesia, and cogwheel rigidity. Most appropriate ini
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tial therapy?
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 A. Levodopa-carbidopa
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 B. Bromocriptinev




 C. Selegiline v

,  D. Amantadine
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Answer: A. Levodopa-carbidopa
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Parkinson’s first-line therapy in elderly is levodopa-
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carbidopa. Dopamine agonists are more often used in younger patients.
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8.

A 22-year-
v


old woman presents with RLQ abdominal pain, fever, and leukocytosis. What is the
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most likely diagnosis?
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 A. Ectopic pregnancy
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 B. Appendicitis
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 C. Ovarian torsion
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 D. Pelvic inflammatory disease
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Answer: B. Appendicitis v v


Classic presentation of appendicitis in a young adult with RLQ pain and leukocytosis.
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9.

A 3-year-
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old girl presents with a barking cough, stridor, and hoarseness. Symptoms worsen a
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t night. Best initial management?
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 A. Racemic epinephrine
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 B. IV dexamethasone
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 C. Humidified air and corticosteroids
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 D. Intubation
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Answer: C. Humidified air and corticosteroids
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Croup (parainfluenza). Mild-
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moderate cases managed with humidified air + corticosteroids. Racemic epi for sev
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ere cases.
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