COMSAE Phase 1 Form 106 Questions With
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 55-year-old man presents with chest pain radiating to the left
arm. ECG shows ST elevation in leads II, III, and aVF. Which
coronary artery is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Correct answer: C. Right coronary artery
Rationale: ST elevation in leads II, III, and aVF indicates an
inferior myocardial infarction, most commonly due to occlusion
of the right coronary artery, which supplies the inferior wall of
the left ventricle in most individuals.
2. A 23-year-old woman presents with fatigue, pallor, and microcytic
anemia. Which laboratory finding is most consistent with iron
deficiency anemia?
A. Increased ferritin
, B. Decreased total iron-binding capacity
C. Increased transferrin saturation
D. Decreased ferritin
Correct answer: D. Decreased ferritin
Rationale: Ferritin reflects iron stores and is decreased in iron
deficiency anemia, while TIBC is typically increased and
transferrin saturation decreased.
3. Which vitamin deficiency is associated with a prolonged PT/INR?
A. Vitamin A
B. Vitamin C
C. Vitamin K
D. Vitamin D
Correct answer: C. Vitamin K
Rationale: Vitamin K is required for synthesis of clotting factors
II, VII, IX, and X; deficiency leads to prolonged PT/INR.
4. A patient presents with chronic cough and hemoptysis. Imaging
shows a cavitary lesion in the upper lobe. What is the most likely
diagnosis?
A. Klebsiella pneumonia
B. Tuberculosis
C. Streptococcus pneumonia
, D. Lung adenocarcinoma
Correct answer: B. Tuberculosis
Rationale: Mycobacterium tuberculosis commonly causes upper
lobe cavitary lesions due to high oxygen tension preference.
5. Which structure is primarily responsible for the production of
surfactant?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Club cells
Correct answer: B. Type II pneumocytes
Rationale: Type II pneumocytes produce pulmonary surfactant,
reducing alveolar surface tension and preventing collapse.
6. A patient with pancreatitis develops hypocalcemia. What is the
mechanism?
A. Increased parathyroid hormone secretion
B. Saponification of fat
C. Decreased vitamin D absorption
D. Increased calcitonin secretion
Correct answer: B. Saponification of fat
, Rationale: Fat necrosis in pancreatitis binds calcium, forming
insoluble soaps and lowering serum calcium.
7. Which neurotransmitter is decreased in Parkinson disease?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
Correct answer: A. Dopamine
Rationale: Parkinson disease is characterized by degeneration of
dopaminergic neurons in the substantia nigra.
8. A 65-year-old man has difficulty initiating movement and a resting
tremor. Which structure is affected?
A. Caudate nucleus
B. Substantia nigra pars compacta
C. Globus pallidus externa
D. Red nucleus
Correct answer: B. Substantia nigra pars compacta
Rationale: Loss of dopaminergic neurons in the substantia nigra
pars compacta leads to Parkinson disease symptoms.
9. Which acid-base disorder is most consistent with vomiting?
A. Metabolic acidosis
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 55-year-old man presents with chest pain radiating to the left
arm. ECG shows ST elevation in leads II, III, and aVF. Which
coronary artery is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
Correct answer: C. Right coronary artery
Rationale: ST elevation in leads II, III, and aVF indicates an
inferior myocardial infarction, most commonly due to occlusion
of the right coronary artery, which supplies the inferior wall of
the left ventricle in most individuals.
2. A 23-year-old woman presents with fatigue, pallor, and microcytic
anemia. Which laboratory finding is most consistent with iron
deficiency anemia?
A. Increased ferritin
, B. Decreased total iron-binding capacity
C. Increased transferrin saturation
D. Decreased ferritin
Correct answer: D. Decreased ferritin
Rationale: Ferritin reflects iron stores and is decreased in iron
deficiency anemia, while TIBC is typically increased and
transferrin saturation decreased.
3. Which vitamin deficiency is associated with a prolonged PT/INR?
A. Vitamin A
B. Vitamin C
C. Vitamin K
D. Vitamin D
Correct answer: C. Vitamin K
Rationale: Vitamin K is required for synthesis of clotting factors
II, VII, IX, and X; deficiency leads to prolonged PT/INR.
4. A patient presents with chronic cough and hemoptysis. Imaging
shows a cavitary lesion in the upper lobe. What is the most likely
diagnosis?
A. Klebsiella pneumonia
B. Tuberculosis
C. Streptococcus pneumonia
, D. Lung adenocarcinoma
Correct answer: B. Tuberculosis
Rationale: Mycobacterium tuberculosis commonly causes upper
lobe cavitary lesions due to high oxygen tension preference.
5. Which structure is primarily responsible for the production of
surfactant?
A. Type I pneumocytes
B. Type II pneumocytes
C. Alveolar macrophages
D. Club cells
Correct answer: B. Type II pneumocytes
Rationale: Type II pneumocytes produce pulmonary surfactant,
reducing alveolar surface tension and preventing collapse.
6. A patient with pancreatitis develops hypocalcemia. What is the
mechanism?
A. Increased parathyroid hormone secretion
B. Saponification of fat
C. Decreased vitamin D absorption
D. Increased calcitonin secretion
Correct answer: B. Saponification of fat
, Rationale: Fat necrosis in pancreatitis binds calcium, forming
insoluble soaps and lowering serum calcium.
7. Which neurotransmitter is decreased in Parkinson disease?
A. Dopamine
B. Serotonin
C. Acetylcholine
D. GABA
Correct answer: A. Dopamine
Rationale: Parkinson disease is characterized by degeneration of
dopaminergic neurons in the substantia nigra.
8. A 65-year-old man has difficulty initiating movement and a resting
tremor. Which structure is affected?
A. Caudate nucleus
B. Substantia nigra pars compacta
C. Globus pallidus externa
D. Red nucleus
Correct answer: B. Substantia nigra pars compacta
Rationale: Loss of dopaminergic neurons in the substantia nigra
pars compacta leads to Parkinson disease symptoms.
9. Which acid-base disorder is most consistent with vomiting?
A. Metabolic acidosis
