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APEA 3P High-Stakes Exam Study Guide Questions & Answers to Pass the Exam (2025–2026): Comprehensive Review for Advanced Practice Nursing Students

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This study guide provides a comprehensive review of the APEA 3P High-Stakes Examination, covering the three foundational components of advanced practice nursing education: Advanced Pathophysiology, Advanced Pharmacology, and Advanced Physical/Health Assessment. Designed for nurse practitioner students preparing for certification readiness assessments and program progression examinations, the guide features verified practice questions and answers, key concepts, and test-taking strategies to strengthen clinical reasoning and improve exam confidence.

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APEA 3P High Stakes Exam Study Guide Qs & Ans to Pass the Exam
(2025 2026), 100% Verified

1. What would cause decrease in Digoxin levels?ans Antacids

2. Taking Pyridium for UTI, what can Pyridium cause?ans Hemolytic

Anemia

3. What can PCOS result in?ans Increased insulin levels (Hyperinsulinemia), Androgens,

Hirsutism

4. What are the anti-hypertensives used in pregnancy?ans Methyldopa

(Alpha-2-Agonist), Labetalol, Nifedipine, Hydralazine

5. What is a characteristic of Placenta Previa?ans Painless, red bleeding

6. What is a chacteristic of Rheumatoid Arthritis?ans Tender, warm, swollen

joints

7. Medications that can cause ototoxicity?ans Aminoglycosides, loop diuretics,

NSAIDs, antihista-mines, nasal decongestants

8. What is the treatment time for enterobiasis?ans 2 weeks

9. What does MCV lab value measure?ans Mean Corpuscular Volume helps diagnose

ditterent types of anemia such as B12 & Folate (Macrocytic) and Fe anemia (Microcytic)

10. Rhogam is given at how many week gestation?ans 27-28 weeks

11. What are Janeway lesions and what do they indicate?ans They are

irregular, non-tender hemorrhagic macules located on the hands and feet. Seen in Infective


, APEA 3P High Stakes Exam Study Guide Qs & Ans to Pass the Exam
(2025 2026), 100% Verified

Endocarditis

12. What are Osler's Nodes and what do they indicate?ans They are split

pea-sized, erythe-matous, tender nodules located on the pads of the fingers and toes. Seen in

Infective Endocarditis

13. What is the recommendation for Warfarin management

when a patient misses a dose?ans If within 12 hours of the dose time, take it. If over 12

hours patient will need a INR redraw

14. What do we need to know about ACEs and ARBs?ans A dry hacking

cough is a common side ettect of ACEs and will go away within a week after discontinuing. ACEs

& ARBs are indicated for patients with DM, CKD, and HTN. Not recommended as 1st line agent with

African Americans & can cause angioedema.

15. Contraindications for Hydrochlorothiazideans Sulfa allergy, PCN

hypersensitivity, Asthma, Gout

16. Systolic Murmurs (Benign)ans MR = Mitral Regurge

(SOB/Fatigue HF) Peyton Manning = Physiologic Murmur

(Asymptomatic)

AS = Aortic Stenosis (Angina, Syncope HF)

MVP = Mitral Valve Prolapse ("Click", Women 14-30, Palpitations, Chest Pain



, APEA 3P High Stakes Exam Study Guide Qs & Ans to Pass the Exam
(2025 2026), 100% Verified

17. Diastolic Murmurs (Abnormal)ans AR = Aortic Regurgitation (Angina, HF,

Dizziness, Chest Pain) MS = Mitral Stenosis (Dyspnea, AFib)

18. What does S1 indicate?ans S1 Closure of the Atrioventricular Valves (Mitral &

Tricuspid Valves)

19. What does S2 indicate?ans S2 Closure of the Semilunar Valves (Aortic & Pulmonic

Valves)






, APEA 3P High Stakes Exam Study Guide Qs & Ans to Pass the Exam
(2025 2026), 100% Verified

20. S3 is often heard in?ans CHF, possibly normal for athletic adolescents

21. S4 is often heard in?ans Diastolic HF, Left Ventricular Hypertrophy (LVH), Poorly

controlled HTN, MI

22. Treatment of Peripheral Artery Disease (PAD)ans Antiplatelets (Plavix,

ASA), Pentoxifylline (Decreases blood viscosity)

23. Diagnosing Peripheral Artery Disease (PAD)ans Gold

Standard = Angiography Ankle Brachial Index (ABI)

24. Coronary Artery Disease (CAD) treatmentans Aotrvastatin/Rosuvastatin =

If LDL>150 use high doses. Watch for LFTs & arthralgia. Change type & dose if issues. Helps

stabilize plaques.

25. What medications are indicated for HF treatment?ans ACEs, ARBs,

ARNI w/BBs, Aldosterone Recepter Antagonists

26. What is the treatment for Sarcopter Scabiei (Scabies)?ans Topical

Permetherin massaged from head to soles of feet and wash ott with shower or bath after 8-

14hrs. Treat again in 1 week.

27. Names of skin lesions?ans Maculeans Flat

<1cm i.e. freckle Papuleans Raised <1cm i.e. acne

Noduleans Raised >1cm i.e. lipoma

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