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Sucralfate (Carafate)
,Drug Class - Answer: Acid-reducing meds
Antiulcer agents
Sucralfate (Carafate)
MOA - Answer: Preparation of sulfated sucrose and aluminum
hydroxide that binds to normal and ulcerated mucosa; Doesn't inhibit
gastric acid or pepsin secretion
Therapeutic effect: Helps coat stomach mucosa with a protective
barrier
Sucralfate (Carafate)
Indications - Answer: Prevent & txt PUD (duodenal ulcers)
Sucralfate (Carafate)
Contraindications - Answer: DON'T GIVE w/ Antacids, H2RA, PPIs
Sucralfate (Carafate)
Side Effects - Answer: Constipation & dry mouth
Sucralfate (Carafate)
,Dietary Restrictions - Answer: *NEVER take w/ antacids
*Give 30 mins before meals and @ bedtime
Sucralfate (Carafate)
Nursing Implications - Answer: *NEVER GIVE w/ Antacids
*Don't give w/ H2RA, PPIs
*Reduce dosage if med is being used long-term
Sucralfate (Carafate)
Teaching - Answer: *Take 30 minutes BEFORE meals and at bedtime
*Take on EMPTY stomach
*NEVER take w/ antacids
*Take ciprofloxacin and other fluoroquinolones, digoxin, phenytoin,
and warfarin 2 HOURS before sucralfate.
, Esomeprazole (Nexium)
Drug Class - Answer: Acid-reducing meds
Proton Pump Inhibitors
"-PRAZOLE"
Esomeprazole (Nexium)
MOA - Answer: Binds to gastric proton pump (H+, K+, ATPase) to
prevent gastric acid release from parietal cells into stomach lumen
Esomeprazole (Nexium)
Indications - Answer: *#1 for PUD (duodeal & gastric ulcers)
*GERD w/ erosive esophagitis
*Zollinger-Ellison syndrome
Esomeprazole (Nexium)
Contraindications - Answer: Hypersensitivity to omeprazole or
esomeprazole