CHEM 162 LAB #6: SYNTHESIS OF ASPIRIN complete solution

GENERAL CHEMISTRY 162
LABORATORY #6: SYNTHESIS
OF ASPIRIN

, INTRODUCTION – GOALS OF LAB

• Synthesize Aspirin (Acetylsalicylic Acid) From
The Starting Material Salicylic Acid
• Evaluate The Purity Of The Product Via
Two Techniques
– Detecting Leftover Salicylic Acid Via Absorbance
Spectroscopy (Beer’s Law)
– Comparing The Melting Point Of The Product Mixture
To The Melting Point Of Pure Aspirin

,INTRODUCTION – TECHNIQUES OF LAB

• Part I – Synthesis Of Aspirin
– Use Microscale Glassware; Conical Vial With Air
Condenser For Synthesis
– Vacuum Filtration Using A Hirsch Funnel
• Part II – Determination Of % Salicylic Acid
– Absorbance Spectrum Of Iron(III)-Salicylate Complex
– Beer’s Law: A = Ɛ𝓁c
• Part III – Melting Point Determination
– Melting Point Apparatus

, REACTION BASICS




(Aspirin)


The Hydroxyl (-OH) Group On The Aromatic Ring Of
Salicylic Acid Reacts With Acetic Anhydride Under
Acidic Conditions (H+) To Form An Ester Product.