BIOL 2030 OPENSTAX MICROBIOLOGY
PROFESSIONAL BIOLOGY PREP
QUESTIONS AND ACCURATE ANSWERS
GRADED A+
●● The alpha toxin of Staphylococcus aureus have similar effect on
human cells as the antibiotic _______ on gram negative bacteria.
Gramicidin
Rifamycin B
Tetracycline
Actinomycin D
Answer: Gramicidin
●● Based on your knowledge of microbial genetics and microbial
pathogenesis, where do you think is/are the likely location/s of the
genetic information for E. coil shiga exotoxins?
Plasmids
Chromosomes
Phage genome
mitochondrial DNA
Answer: Plasmids
Chromosomes
,Phage genome
●● Based on your knowledge of microbial genetics and microbial
pathogenesis, where do you think the genetic information for endotoxins
are located?
Phage genome
Chromosomes
mitochondial DNA
Plasmids
Answer: Chromosomes
●● Why is antibiotic treatment of gram negative bacteria NOT always a
good idea?
Because
it can result in release of endotoxin
no antibiotic is useful because it's a mixed infection
antibiotics do not work on gram negative bacteria due to the presence of
outer membrane
gram negative are already antibiotic resistant
Answer: it can result in release of endotoxin
●● The ability to survive in the harsh environment of the
phagolysosome is a virulence factor produced by
,Uropathogenic Escherichia coli.
Vibrio cholera.
Bordetella pertussis.
Helicobacter pylori.
Coxiella burnetti.
Answer: Coxiella burnetti.
●● Match the organism with their virulence factor.
Pseudomonas aeruginosa
Yersinia pestis
Bordetella pertussis
Staphyloccus aureus
Answer: Pseudomonas aeruginosa- T2SS
Yersinia pestis- T3SS
Bordetella pertussis- T4SS
Staphyloccus aureus- Protein A
●● All of the following are bacterial structures responsible for
attachment to the host cells or structures EXCEPT
LPS or Lipid A of E.coli
Type I pili of Escherichia coli
, Type IV pili of Neisseria meningitidis
Pertactin of Bordetella pertussis
Protein M of Streptococcus pyogenes
Answer: LPS or Lipid A of E.coli
●● Shiga toxins of E. coli O157: H7 mechanism of killing affected cells
is due to
Protease
Protein synthesis inhibitor
Superantigen
Second messenger pathway disruptor
Cell membrane disruptor
Answer: Protein synthesis inhibitor
●● The cholera toxin causes ADP-ribosylation of its target cells and is
an example of
A cytotoxin that kills host cells
A neurotoxin that causes irreversible muscle relaxation
neurotoxin that causes irreversible muscle contraction
An enterotoxin that disrupts function of the intestine
Answer: An enterotoxin that disrupts function of the intestine
PROFESSIONAL BIOLOGY PREP
QUESTIONS AND ACCURATE ANSWERS
GRADED A+
●● The alpha toxin of Staphylococcus aureus have similar effect on
human cells as the antibiotic _______ on gram negative bacteria.
Gramicidin
Rifamycin B
Tetracycline
Actinomycin D
Answer: Gramicidin
●● Based on your knowledge of microbial genetics and microbial
pathogenesis, where do you think is/are the likely location/s of the
genetic information for E. coil shiga exotoxins?
Plasmids
Chromosomes
Phage genome
mitochondrial DNA
Answer: Plasmids
Chromosomes
,Phage genome
●● Based on your knowledge of microbial genetics and microbial
pathogenesis, where do you think the genetic information for endotoxins
are located?
Phage genome
Chromosomes
mitochondial DNA
Plasmids
Answer: Chromosomes
●● Why is antibiotic treatment of gram negative bacteria NOT always a
good idea?
Because
it can result in release of endotoxin
no antibiotic is useful because it's a mixed infection
antibiotics do not work on gram negative bacteria due to the presence of
outer membrane
gram negative are already antibiotic resistant
Answer: it can result in release of endotoxin
●● The ability to survive in the harsh environment of the
phagolysosome is a virulence factor produced by
,Uropathogenic Escherichia coli.
Vibrio cholera.
Bordetella pertussis.
Helicobacter pylori.
Coxiella burnetti.
Answer: Coxiella burnetti.
●● Match the organism with their virulence factor.
Pseudomonas aeruginosa
Yersinia pestis
Bordetella pertussis
Staphyloccus aureus
Answer: Pseudomonas aeruginosa- T2SS
Yersinia pestis- T3SS
Bordetella pertussis- T4SS
Staphyloccus aureus- Protein A
●● All of the following are bacterial structures responsible for
attachment to the host cells or structures EXCEPT
LPS or Lipid A of E.coli
Type I pili of Escherichia coli
, Type IV pili of Neisseria meningitidis
Pertactin of Bordetella pertussis
Protein M of Streptococcus pyogenes
Answer: LPS or Lipid A of E.coli
●● Shiga toxins of E. coli O157: H7 mechanism of killing affected cells
is due to
Protease
Protein synthesis inhibitor
Superantigen
Second messenger pathway disruptor
Cell membrane disruptor
Answer: Protein synthesis inhibitor
●● The cholera toxin causes ADP-ribosylation of its target cells and is
an example of
A cytotoxin that kills host cells
A neurotoxin that causes irreversible muscle relaxation
neurotoxin that causes irreversible muscle contraction
An enterotoxin that disrupts function of the intestine
Answer: An enterotoxin that disrupts function of the intestine
