Case Studies Instructions
Urinary Function
Part 1– Please complete only one case (of your choosing) from Part 1. Only
one case is required.
Case 1: A 54-year-old female complains of a “burning” when urinating x 2 days. She shared, “I
feel like I have to pee every 60 minutes or so.” She denies suprapubic/back pain and fever.
Past medical history: high cholesterol, high blood pressure.
Medications: atorvastatin for cholesterol.
Allergies: Penicillin (skin rash).
Physical examination: temperature 98.8°F; pulse 80 bpm; respirations 14 per minute; blood
pressure 114/68 mmHg.
Examination unremarkable; no suprapubic or costovertebral angle tenderness.
Urine dipstick reveals moderate leukocytes and positive nitrites, with all other values within
normal limits.
1. What is the most likely diagnosis?
The most likely diagnosis is acute uncomplicated cystitis, which is a lower urinary tract
infection (Bono & Leslie, 2025; Dlugasch & Story, 2023).
2. Which pathogen is likely causing this disorder?
The most common causative organism for uncomplicated cystitis is Escherichia coli (E.
coli), responsible for approximately 80–90% of cases in women (Bono & Leslie, 2025).
3. What is the likely mode of transmission? Discuss data that support your decision.
The likely mode of transmission is ascending infection from the urethra, where perineal
or gastrointestinal flora enter the urinary tract. This diagnosis is supported by:
● Dysuria
● Increased urinary frequency
● Positive nitrites – indicates gram-negative organisms such as E. coli
, ● Moderate leukocyte esterase – inflammation/infection
● Afebrile, no CVA tenderness – suggests lower, not upper, UTI
This presentation aligns with diagnostic criteria for acute uncomplicated cystitis (Bono &
Leslie, 2025; Nicolle et al., 2019).
4. What diagnostic test, if any, should be done?
A urine dipstick plus clinical history is often sufficient for diagnosis. However, a urine
culture is recommended if symptoms persist, recur, or if treatment failure occurs. It may
also be used to guide antibiotic choice due to resistance patterns (Nicolle et al., 2019).
5. What are diagnostic test findings would support your diagnosis?
If a urine culture is performed, the expected diagnostic findings for
acute uncomplicated cystitis include growth of ≥100,000 colony-
forming units per milliliter (CFU/mL) of a single uropathogen—most
commonly Escherichia coli—along with an antibiotic susceptibility
panel to help guide treatment and ensure appropriate antimicrobial
selection (Bono & Leslie, 2025; Nicolle et al., 2019). These findings
support both the diagnosis and stewardship-based treatment
decisions, which are emphasized in current U.S. clinical practice
guidelines.
6. Develop a treatment plan for this client.
Given the patient’s symptoms and urinalysis findings, treatment should follow current
recommendations for acute uncomplicated cystitis. According to U.S. clinical guidelines,
nitrofurantoin 100 mg twice daily for five days is a preferred first-line option since it is
effective against E. coli and has relatively low resistance rates (Nicolle et al., 2019 ).
Another appropriate option is trimethoprim–sulfamethoxazole (TMP–SMX), but only if
local resistance is known to be below 20% and there is no sulfa allergy (Nicolle et al.,
2019 ). Fosfomycin 3 g as a single oral dose is also supported in the literature and may
be useful when adherence to a multi-day regimen could be an issue (Bono & Leslie,
2025).
In addition to antibiotics, patient education is key. I would encourage adequate hydration,
remind the patient to void after sexual activity, and explain the importance of completing
the full antibiotic course even if symptoms improve early. It’s also important to review
warning signs such as fever, flank pain, or worsening symptoms, which may indicate
possible progression to pyelonephritis. For short-term symptom relief, phenazopyridine
could be used, but only as an adjunct—not a substitute—for antimicrobial
treatment(Bono & Leslie, 2025; Dlugasch & Story, 2023 ). I would recommend follow-
up if symptoms do not improve within 48–72 hours or if systemic symptoms develop.
References
, Bono, M. J., & Leslie, S. W. (2025). Uncomplicated urinary tract infections. In Statpearls
[internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK470195/
Dlugasch, L., & Story, L. (2023). Applied pathophysiology for the advanced practice nurse
(2nd ed.). Jones & Bartlett Learning.
Nicolle, L. E., Gupta, K., Bradley, S. F., Colgan, R., DeMuri, G. P., Drekonja, D., Eckert,
L. O., Geerlings, S. E., Köves, B., Hooton, T. M., Juthani-Mehta, M., Knight, S. L.,
Saint, S., Schaeffer, A. J., Trautner, B., Wullt, B., & Siemieniuk, R. (2019). Clinical
practice guideline for the management of asymptomatic bacteriuria: 2019 update by
the infectious diseases society of America. Clinical Infectious Diseases, 68(10), e83–
e110. https://doi.org/10.1093/cid/ciy1121
Part 2 – Please complete all of Part 2.
A 46-year-old female is asymptomatic and has a routine urinalysis as part of her annual physical.
The urinalysis with microscopy report is as follows:
Urinalysis, complete Result WNL Reference Range
Color Dark yellow Yellow
Appearance Cloudy Clear
Specific gravity 1.023 1.001–1.035
pH ≤ 5.0 5.0–8.0
Glucose Negative (-) Negative (-)
Bilirubin Negative (-) Negative (-)
Ketones Negative (-) Negative (-)
Occult blood 1+ Negative (-)
Protein Negative (-) Negative (-)
Nitrite Negative (-) Negative (-)
Leukocyte esterase Negative (-) Negative (-)
White blood cells None seen ≤ 5 /HPF
Red blood cells 0–2 ≤ 2 /HPF