ONCOLOGY NAPLEX REVIEW EXAM
QUESTIONS AND ANSWERS 2026
VERIFIED.
Anti-emetic regimen for highly emetogenic chemotherapy - ANS fosapretant + dexmethasone
+
ondansetron + olanzapine
3 or 4 drug regimen
NK1-RA + 5HT3- RA + dexmethasone + olanzapine
nadir - ANS lowest point that WBS and platelets reach in chemo
usually occurs 7-14 days after
Tamoxifen MOA - ANS SERM - Selective Estrogen Receptor Modulators - block estrogen in
breast tissue but can act as estrogen agonists elsewhere.
Used when tumor is estrogen-receptor positive.
treat and prevent recurrence of ER(+)breast cancer
**can be used in BOTH pre and post-menopausal women
-Antagonist at breast
@COPYRIGHT ALL RIGHTS RESERVED PAGE 1 OF 22
,-AGONIST at bone and uterus
(detrimental agonistic effect by increasing the risk of uterine cancer and of thrombo-embolism)
chemo agents that are CELL cycle INDEPENDENT - ANS alkalyating agents
(cyclophosphamide)
anthracycline agents (doxorubicin)
platinum agents (cisplatin)
Zofran MOA - ANS 5HT3 antagonist (-)
Amofostine (ethiyol) - ANS given with cisplatin to reduce risk of renal toxicities
-given prophylactically with hydration
Neupogen - ANS (Filgrastim)
Colony stimulating factor
Stimulates neutrophil production; decreases infection in neutropenic pts
IV, subcut
SEs: Splenic rupture, ARDS, allergic rxn, medullary bone pain
@COPYRIGHT ALL RIGHTS RESERVED PAGE 2 OF 22
, NCs: do not admin w/in 24 hrs either side of chemo
Bone pain is common SE, mgmt w opioids if necc
Pegfilgrastim - ANS Neulasta
Hematopoietic Agent/Colony Stimulating Factor
Given once (t1/2 14 days)
Prostate cancer screening - ANS digital rectal exam
-Start screening at age 50; High risk begin discussions at 40-45
-If PSA < 2.5; test q 2yrs
-If PSA > 2.5; annual testing
-If PSA > 4.0; refer for evaluation
Aloxi - ANS Palonsetron
antiemetic
(blocks serotonin)
IV only
treatment for chemo-induced diarrea - ANS diphenoxylate + atropine
loperamide
atropine
@COPYRIGHT ALL RIGHTS RESERVED PAGE 3 OF 22
QUESTIONS AND ANSWERS 2026
VERIFIED.
Anti-emetic regimen for highly emetogenic chemotherapy - ANS fosapretant + dexmethasone
+
ondansetron + olanzapine
3 or 4 drug regimen
NK1-RA + 5HT3- RA + dexmethasone + olanzapine
nadir - ANS lowest point that WBS and platelets reach in chemo
usually occurs 7-14 days after
Tamoxifen MOA - ANS SERM - Selective Estrogen Receptor Modulators - block estrogen in
breast tissue but can act as estrogen agonists elsewhere.
Used when tumor is estrogen-receptor positive.
treat and prevent recurrence of ER(+)breast cancer
**can be used in BOTH pre and post-menopausal women
-Antagonist at breast
@COPYRIGHT ALL RIGHTS RESERVED PAGE 1 OF 22
,-AGONIST at bone and uterus
(detrimental agonistic effect by increasing the risk of uterine cancer and of thrombo-embolism)
chemo agents that are CELL cycle INDEPENDENT - ANS alkalyating agents
(cyclophosphamide)
anthracycline agents (doxorubicin)
platinum agents (cisplatin)
Zofran MOA - ANS 5HT3 antagonist (-)
Amofostine (ethiyol) - ANS given with cisplatin to reduce risk of renal toxicities
-given prophylactically with hydration
Neupogen - ANS (Filgrastim)
Colony stimulating factor
Stimulates neutrophil production; decreases infection in neutropenic pts
IV, subcut
SEs: Splenic rupture, ARDS, allergic rxn, medullary bone pain
@COPYRIGHT ALL RIGHTS RESERVED PAGE 2 OF 22
, NCs: do not admin w/in 24 hrs either side of chemo
Bone pain is common SE, mgmt w opioids if necc
Pegfilgrastim - ANS Neulasta
Hematopoietic Agent/Colony Stimulating Factor
Given once (t1/2 14 days)
Prostate cancer screening - ANS digital rectal exam
-Start screening at age 50; High risk begin discussions at 40-45
-If PSA < 2.5; test q 2yrs
-If PSA > 2.5; annual testing
-If PSA > 4.0; refer for evaluation
Aloxi - ANS Palonsetron
antiemetic
(blocks serotonin)
IV only
treatment for chemo-induced diarrea - ANS diphenoxylate + atropine
loperamide
atropine
@COPYRIGHT ALL RIGHTS RESERVED PAGE 3 OF 22
