Place of taxanes in chemotherapy
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Taxanes can either be used as adjuvant therapy or in the therapy of
metastatic disease. They are not first line agents.
Mechanism of action of imatinib
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A specific inhibitor of tyrosine kinase enzymes. They are specific for the
tyrosine kinase domain in the abl, c-kit, and PDGF genes and receptors. By
inhibiting these aspects, they reduce tyrosine kinase activity.
,[REFERENCE] Examples of monoclonal antibody drugs and their nomenclature
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- Trastuzumab (tras, tu = breast tumour (HER-2), zu = humanised, mab).
- Rituximab (ri, tu = CD20 (surface protein on B cells), xi = chimeric, mab).
- Bevacizumab (beva, ci = VEGF, zu = humanised, mab).
Common adverse effects of chemotherapy (STANDIN)
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- Skin reactions.
- Thrombocytopaenia.
- Anaemia.
- Nausea and vomiting.
- Diarrhoea.
- Infections.
- Neutropaenia.
SEE SLIDE 22 for full list.
Three factors that the mechanism of action of cytotoxic drugs is dependent on
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, - Membrane transport (drug delivery to the target site).
- Intracellular activation (e.g. methotrexate).
- Drug interaction with intracellular targets (nucleic acids, enzymes,
membranes, microtubules, and hormone and growth factor receptors).
- Cellular repair of drug-induced injury (reduces cytotoxic effect).
- Pharmacokinetics (absorption, distribution, metabolism, and excretion).
Types of monoclonal antibodies
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Types:
- 100% mouse (mouse).
- 33% mouse (chimeric - Fc portion is human).
- 5% to 10% mouse (humanised - only antigen binding site is mouse).
- 100% human (fully human - minimised immunogenicity, multiple treatments
possible, and improved serum half-life).
Targeted therapy - Drugs targeting apoptosis
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Drugs that can cause cell death by interfering with proteins involved in the
apoptotic process. These drugs are proteasome inhibitors such as
bortezomib.
Common long-term adverse effects of cytotoxics
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Taxanes can either be used as adjuvant therapy or in the therapy of
metastatic disease. They are not first line agents.
Mechanism of action of imatinib
Give this one a try later!
A specific inhibitor of tyrosine kinase enzymes. They are specific for the
tyrosine kinase domain in the abl, c-kit, and PDGF genes and receptors. By
inhibiting these aspects, they reduce tyrosine kinase activity.
,[REFERENCE] Examples of monoclonal antibody drugs and their nomenclature
Give this one a try later!
- Trastuzumab (tras, tu = breast tumour (HER-2), zu = humanised, mab).
- Rituximab (ri, tu = CD20 (surface protein on B cells), xi = chimeric, mab).
- Bevacizumab (beva, ci = VEGF, zu = humanised, mab).
Common adverse effects of chemotherapy (STANDIN)
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- Skin reactions.
- Thrombocytopaenia.
- Anaemia.
- Nausea and vomiting.
- Diarrhoea.
- Infections.
- Neutropaenia.
SEE SLIDE 22 for full list.
Three factors that the mechanism of action of cytotoxic drugs is dependent on
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, - Membrane transport (drug delivery to the target site).
- Intracellular activation (e.g. methotrexate).
- Drug interaction with intracellular targets (nucleic acids, enzymes,
membranes, microtubules, and hormone and growth factor receptors).
- Cellular repair of drug-induced injury (reduces cytotoxic effect).
- Pharmacokinetics (absorption, distribution, metabolism, and excretion).
Types of monoclonal antibodies
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Types:
- 100% mouse (mouse).
- 33% mouse (chimeric - Fc portion is human).
- 5% to 10% mouse (humanised - only antigen binding site is mouse).
- 100% human (fully human - minimised immunogenicity, multiple treatments
possible, and improved serum half-life).
Targeted therapy - Drugs targeting apoptosis
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Drugs that can cause cell death by interfering with proteins involved in the
apoptotic process. These drugs are proteasome inhibitors such as
bortezomib.
Common long-term adverse effects of cytotoxics
Give this one a try later!
