Nitrosoureas
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-subgroup of alkylating agents
-able to cross the blood-brain barrier (effective in treating some brain
tumors, melanomas, lymphomas)
-Carmustine (BiCNU)
-Lomustine (CeeNu)
-Streptozocin (Zanosar)
-pulmonary monitoring recommended
Monoclonal Antibody Targeted Therapy
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, - end in -mab
-relatively large in size and therefore usually cannot enter cells
-extracellular or transmembrane
-man made version of antibodies that are designed to attack a very specific
target on cancer cells
-usually from mice
T-Cell
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-Can only recognize antigens when they are presented to them by
"presenting cells"
-Recognize phagocytized fragments of an antigen that are put on the
surface of antigen-presenting cells
Protein tyrosine kinases phosphorylates
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, -turned on by giving up a phosphate molecule
-the message is now send via a "bucket bridage", or passing the message
from one molecule to other signaling molecules until the message gets first
into the cell nucleus
-where it is transcribed
Cell Cycling Time
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Amount of time from mitosis to mitosis
Alkylating Agents
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-function by causing a break in the DNA helix strand, causing interference
with DNA replication, which results in cell death
DNA Damage Checkpoints
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, -If DNA damage is present, cells are programmed to stop dividing or
undergo apoptosis (programmed cell death)
-The retinoblastoma protein (Rb), p53, and p21 are some of the most well-
understood inhibitory proteins (IP)
Receptor
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-molecule inside or on the surface of a cell that binds to a specific
substance causes a specific effect in that cell
Adaptive Immunity
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-Stimulated if innate immunity is insufficient
-leads to immune system memory
-Humoral immunity
-Cell-mediated immunity
-Regulatory T-cells
Neutopenia RF
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Give this one a try later!
-subgroup of alkylating agents
-able to cross the blood-brain barrier (effective in treating some brain
tumors, melanomas, lymphomas)
-Carmustine (BiCNU)
-Lomustine (CeeNu)
-Streptozocin (Zanosar)
-pulmonary monitoring recommended
Monoclonal Antibody Targeted Therapy
Give this one a try later!
, - end in -mab
-relatively large in size and therefore usually cannot enter cells
-extracellular or transmembrane
-man made version of antibodies that are designed to attack a very specific
target on cancer cells
-usually from mice
T-Cell
Give this one a try later!
-Can only recognize antigens when they are presented to them by
"presenting cells"
-Recognize phagocytized fragments of an antigen that are put on the
surface of antigen-presenting cells
Protein tyrosine kinases phosphorylates
Give this one a try later!
, -turned on by giving up a phosphate molecule
-the message is now send via a "bucket bridage", or passing the message
from one molecule to other signaling molecules until the message gets first
into the cell nucleus
-where it is transcribed
Cell Cycling Time
Give this one a try later!
Amount of time from mitosis to mitosis
Alkylating Agents
Give this one a try later!
-function by causing a break in the DNA helix strand, causing interference
with DNA replication, which results in cell death
DNA Damage Checkpoints
Give this one a try later!
, -If DNA damage is present, cells are programmed to stop dividing or
undergo apoptosis (programmed cell death)
-The retinoblastoma protein (Rb), p53, and p21 are some of the most well-
understood inhibitory proteins (IP)
Receptor
Give this one a try later!
-molecule inside or on the surface of a cell that binds to a specific
substance causes a specific effect in that cell
Adaptive Immunity
Give this one a try later!
-Stimulated if innate immunity is insufficient
-leads to immune system memory
-Humoral immunity
-Cell-mediated immunity
-Regulatory T-cells
Neutopenia RF
Give this one a try later!
