COMSAE Phase 2 – Form BSA 106 (Classic
Preventative and Predictive Medicine Set)
(2026 Edition): Comprehensive Multiple-
Choice Questions, Answers, and Detailed
Rationales
1. A 52-year-old woman with no significant medical history
asks about breast cancer screening. Which screening test is
recommended for average-risk women?
A. Breast MRI annually beginning at age 25
B. Monthly breast ultrasound
C. Mammography beginning at age 40–50 depending on
guideline and risk assessment
D. PET scan every 2 years
E. Serum CA 15-3 testing
Answer: C
Rationale: Mammography remains the primary screening tool
for average-risk women. MRI is reserved for high-risk
patients. Tumor markers are not recommended for routine
screening.
2. A 65-year-old man with a 40-pack-year smoking history
quit 5 years ago. Which preventive screening is indicated?
,A. Chest radiograph annually
B. Sputum cytology annually
C. Pulmonary function testing annually
D. Low-dose chest CT annually
E. Bronchoscopy every 2 years
Answer: D
Rationale: Annual low-dose CT screening is recommended for
adults aged 50–80 with significant smoking histories who
currently smoke or quit within the past 15 years.
3. Which vaccine is routinely recommended during every
pregnancy?
A. HPV vaccine
B. MMR vaccine
C. Varicella vaccine
D. Yellow fever vaccine
E. Tdap vaccine
Answer: E
Rationale: Tdap is recommended during each pregnancy,
preferably between 27 and 36 weeks gestation, to protect
newborns from pertussis.
4. A 58-year-old patient has a blood pressure of 152/94 mm
Hg on three visits. What is the most appropriate preventive
intervention?
,A. Observe for 1 year
B. Repeat BP in 2 years
C. Lifestyle modification only
D. Lifestyle modification plus antihypertensive therapy
E. Aspirin therapy only
Answer: D
Rationale: Persistent stage 2 hypertension generally warrants
pharmacologic therapy along with lifestyle modification to
reduce cardiovascular risk.
5. Which intervention provides the greatest reduction in
mortality among smokers?
A. Vitamin supplementation
B. Annual chest radiographs
C. Spirometry screening
D. Nicotine reduction alone
E. Smoking cessation
Answer: E
Rationale: Smoking cessation substantially reduces
cardiovascular, pulmonary, and cancer-related mortality.
6. Which patient should receive statin therapy for primary
prevention?
A. Healthy 20-year-old athlete
B. Healthy 30-year-old with LDL 90 mg/dL
C. 55-year-old diabetic patient with LDL 120 mg/dL
, D. Healthy teenager with obesity only
E. Healthy adult with HDL 70 mg/dL
Answer: C
Rationale: Adults aged 40–75 with diabetes are generally
candidates for statin therapy for primary prevention.
7. Which counseling intervention most effectively reduces
transmission of sexually transmitted infections?
A. Routine antibiotic use
B. Herbal supplements
C. Annual urinalysis
D. Consistent condom use and risk-reduction counseling
E. Vitamin C supplementation
Answer: D
Rationale: Barrier protection and behavioral counseling
significantly reduce STI transmission risk.
8. A 50-year-old patient asks about colorectal cancer
screening. Which test is considered acceptable?
A. Monthly CT abdomen
B. Serum CEA testing
C. Upper endoscopy every year
D. Abdominal ultrasound annually
E. Colonoscopy at recommended intervals
Answer: E
Preventative and Predictive Medicine Set)
(2026 Edition): Comprehensive Multiple-
Choice Questions, Answers, and Detailed
Rationales
1. A 52-year-old woman with no significant medical history
asks about breast cancer screening. Which screening test is
recommended for average-risk women?
A. Breast MRI annually beginning at age 25
B. Monthly breast ultrasound
C. Mammography beginning at age 40–50 depending on
guideline and risk assessment
D. PET scan every 2 years
E. Serum CA 15-3 testing
Answer: C
Rationale: Mammography remains the primary screening tool
for average-risk women. MRI is reserved for high-risk
patients. Tumor markers are not recommended for routine
screening.
2. A 65-year-old man with a 40-pack-year smoking history
quit 5 years ago. Which preventive screening is indicated?
,A. Chest radiograph annually
B. Sputum cytology annually
C. Pulmonary function testing annually
D. Low-dose chest CT annually
E. Bronchoscopy every 2 years
Answer: D
Rationale: Annual low-dose CT screening is recommended for
adults aged 50–80 with significant smoking histories who
currently smoke or quit within the past 15 years.
3. Which vaccine is routinely recommended during every
pregnancy?
A. HPV vaccine
B. MMR vaccine
C. Varicella vaccine
D. Yellow fever vaccine
E. Tdap vaccine
Answer: E
Rationale: Tdap is recommended during each pregnancy,
preferably between 27 and 36 weeks gestation, to protect
newborns from pertussis.
4. A 58-year-old patient has a blood pressure of 152/94 mm
Hg on three visits. What is the most appropriate preventive
intervention?
,A. Observe for 1 year
B. Repeat BP in 2 years
C. Lifestyle modification only
D. Lifestyle modification plus antihypertensive therapy
E. Aspirin therapy only
Answer: D
Rationale: Persistent stage 2 hypertension generally warrants
pharmacologic therapy along with lifestyle modification to
reduce cardiovascular risk.
5. Which intervention provides the greatest reduction in
mortality among smokers?
A. Vitamin supplementation
B. Annual chest radiographs
C. Spirometry screening
D. Nicotine reduction alone
E. Smoking cessation
Answer: E
Rationale: Smoking cessation substantially reduces
cardiovascular, pulmonary, and cancer-related mortality.
6. Which patient should receive statin therapy for primary
prevention?
A. Healthy 20-year-old athlete
B. Healthy 30-year-old with LDL 90 mg/dL
C. 55-year-old diabetic patient with LDL 120 mg/dL
, D. Healthy teenager with obesity only
E. Healthy adult with HDL 70 mg/dL
Answer: C
Rationale: Adults aged 40–75 with diabetes are generally
candidates for statin therapy for primary prevention.
7. Which counseling intervention most effectively reduces
transmission of sexually transmitted infections?
A. Routine antibiotic use
B. Herbal supplements
C. Annual urinalysis
D. Consistent condom use and risk-reduction counseling
E. Vitamin C supplementation
Answer: D
Rationale: Barrier protection and behavioral counseling
significantly reduce STI transmission risk.
8. A 50-year-old patient asks about colorectal cancer
screening. Which test is considered acceptable?
A. Monthly CT abdomen
B. Serum CEA testing
C. Upper endoscopy every year
D. Abdominal ultrasound annually
E. Colonoscopy at recommended intervals
Answer: E
