Page 1 of 81
NCLEX PRACTICE TEST QUESTIONS- NURSING EXAM 2
NEWEST 2026 EXAM LATEST VERSION SOLVED
QUESTIONS & ANSWERS VERIFIED 100 %
Which factors increase a patient's risk for developing active TB? (Select all
that apply)
A. HIV infection
B. Age 25 years
C. Diabetes mellitus
D. Living alone
E. Working in healthcare
Answers: A, C, E
Rationale:
A - CORRECT: HIV/immunocompromised status significantly increases TB risk and
MDR TB
C - CORRECT: Chronic diseases like diabetes reduce immunity, increasing
reactivation risk
E - CORRECT: Healthcare workers have occupational exposure risk
B - INCORRECT: Older adults (not young adults) are at higher risk for reactivation
D - INCORRECT: Crowded living (not living alone) increases transmission risk
A patient taking isoniazid (INH) for TB reports nausea every morning after
taking the medication. What should the nurse recommend?
A. Stop the medication immediately
B. Take the medication at bedtime instead
C. Take the medication on an empty stomach
D. Reduce the dose by half
Answer: B - Take the medication at bedtime instead
, Page 2 of 81
Rationale: The textbook states: "Drugs to treat TB often cause nausea. If this
happens, instruct the patient to take once-a-day drugs at night." This helps patients
sleep through the nausea. Antiemetics can also be prescribed. Taking with a small
carbohydrate snack may help if food doesn't interfere with absorption. Never stop or
reduce doses without provider guidance.
A patient has been taking TB medications for 3 weeks and reports missing 4-5
doses over the past week. What is the nurse's priority concern?
A. Treatment will take longer to complete
B. Development of drug-resistant TB
C. Increased side effects when restarting
D. Need for hospitalization
Answer: B - Development of drug-resistant
TB
Rationale: The textbook emphasizes: "The most common cause of MDR TB and
XDR TB is misuse or mismanagement of drug therapy." Missing doses allows
resistant organisms to emerge. The nurse must stress that "not taking the drugs as
prescribed could lead to a drug-resistant infection." This is the most serious
consequence of nonadherence.
Which intervention best ensures medication adherence in a patient at high risk
for nonadherence to TB therapy?
A. Providing written instructions
B. Implementing directly observed therapy (DOT)
C. Scheduling monthly follow-up appointments
D. Prescribing antiemetics
Answer: B - Implementing directly observed therapy (DOT)
Rationale: The textbook states: "Patients who are at risk for noncompliance or
nonadherence with an anti-TB drug regimen may be placed on directly observed
therapy (DOT). This means that an HCW must observe and validate patient
compliance with the drug regimen. DOT has been very effective at reducing the
spread of multidrug-resistant TB."
A nurse is teaching a patient starting TB medication therapy. Which
statements should be included? (Select all that apply)
, Page 3 of 81
A. "Take all medications exactly as prescribed for the full duration."
B. "You can stop when you feel better."
C. "Nausea is common and can be managed."
D. "Missing doses may lead to drug resistance."
E. "Sputum tests are needed every 4 weeks."
Answers: A, C, D, E
Rationale:
A - CORRECT: "Stress the importance of taking each drug regularly, exactly as
prescribed, for as long as it is prescribed"
C - CORRECT: "Drugs to treat TB often cause nausea" - manageable with timing
changes and antiemetics
D - CORRECT: "Not taking the drugs as prescribed could lead to a drug-resistant
infection"
E - CORRECT: "Sputum specimens are needed about every 4 weeks once drug
therapy is initiated"
B - INCORRECT: Never stop early; full duration essential
A patient taking rifampin for TB asks why their urine has turned orange. What
is the nurse's best response?
A. "This indicates liver damage; we need to stop the medication."
B. "This is an expected side effect of rifampin."
C. "You may be dehydrated; increase your fluid intake."
D. "This means the medication isn't working properly."
Answer: B - "This is an expected side effect of rifampin."
Rationale: Rifampin causes orange discoloration of body fluids (urine, tears, sweat,
saliva). This is a harmless, expected side effect. Patients should be counseled that
this will occur and may stain contact lenses and clothing. It does NOT indicate
toxicity or treatment failure.
A female patient taking rifampin for TB uses oral contraceptives for birth
control. What should the nurse teach?
A. Rifampin increases contraceptive effectiveness
B. Rifampin decreases contraceptive effectiveness
, Page 4 of 81
C. No interaction exists between these medications
D. Contraceptives should be stopped during TB treatment
Answer: B - Rifampin decreases contraceptive effectiveness
Rationale: Rifampin is a potent enzyme inducer that decreases effectiveness of oral
contraceptives, leading to potential contraceptive failure. Patients should use
alternative or additional birth control methods during rifampin therapy. This is a
critical drug interaction for women of childbearing age.
Which patient statement indicates understanding of rifampin therapy?
A. "I'll take this medication with antacids to prevent stomach upset."
B. "My soft contact lenses may become permanently stained."
C. "I can drink alcohol occasionally while on this medication."
D. "I should take this on a full stomach"
Answer: B - "My soft contact lenses may become permanently stained."
Rationale: Rifampin's orange discoloration affects tears and can permanently stain
soft contact lenses. Patients should avoid wearing them or switch to glasses during
treatment. Rifampin should be taken on an empty stomach (not with food/antacids).
Alcohol should be avoided due to hepatotoxicity risk.
A patient with newly diagnosed rheumatoid arthritis reports joint stiffness that
is worst in the morning. How long should the nurse explain this stiffness
typically lasts?
A. 15-30 minutes
B. 1-2 hours
C. Several hours
D. All day
Answer: C - Several hours
Rationale: The textbook states: "The patient usually has frequent morning stiffness,
which can last for several hours after awakening." This prolonged morning stiffness
is a hallmark symptom of RA and distinguishes it from osteoarthritis, where stiffness
typically resolves within 30 minutes.
A patient with RA suddenly develops one hot, swollen, extremely painful knee
that is out of proportion to their other joints. What is the nurse's priority
NCLEX PRACTICE TEST QUESTIONS- NURSING EXAM 2
NEWEST 2026 EXAM LATEST VERSION SOLVED
QUESTIONS & ANSWERS VERIFIED 100 %
Which factors increase a patient's risk for developing active TB? (Select all
that apply)
A. HIV infection
B. Age 25 years
C. Diabetes mellitus
D. Living alone
E. Working in healthcare
Answers: A, C, E
Rationale:
A - CORRECT: HIV/immunocompromised status significantly increases TB risk and
MDR TB
C - CORRECT: Chronic diseases like diabetes reduce immunity, increasing
reactivation risk
E - CORRECT: Healthcare workers have occupational exposure risk
B - INCORRECT: Older adults (not young adults) are at higher risk for reactivation
D - INCORRECT: Crowded living (not living alone) increases transmission risk
A patient taking isoniazid (INH) for TB reports nausea every morning after
taking the medication. What should the nurse recommend?
A. Stop the medication immediately
B. Take the medication at bedtime instead
C. Take the medication on an empty stomach
D. Reduce the dose by half
Answer: B - Take the medication at bedtime instead
, Page 2 of 81
Rationale: The textbook states: "Drugs to treat TB often cause nausea. If this
happens, instruct the patient to take once-a-day drugs at night." This helps patients
sleep through the nausea. Antiemetics can also be prescribed. Taking with a small
carbohydrate snack may help if food doesn't interfere with absorption. Never stop or
reduce doses without provider guidance.
A patient has been taking TB medications for 3 weeks and reports missing 4-5
doses over the past week. What is the nurse's priority concern?
A. Treatment will take longer to complete
B. Development of drug-resistant TB
C. Increased side effects when restarting
D. Need for hospitalization
Answer: B - Development of drug-resistant
TB
Rationale: The textbook emphasizes: "The most common cause of MDR TB and
XDR TB is misuse or mismanagement of drug therapy." Missing doses allows
resistant organisms to emerge. The nurse must stress that "not taking the drugs as
prescribed could lead to a drug-resistant infection." This is the most serious
consequence of nonadherence.
Which intervention best ensures medication adherence in a patient at high risk
for nonadherence to TB therapy?
A. Providing written instructions
B. Implementing directly observed therapy (DOT)
C. Scheduling monthly follow-up appointments
D. Prescribing antiemetics
Answer: B - Implementing directly observed therapy (DOT)
Rationale: The textbook states: "Patients who are at risk for noncompliance or
nonadherence with an anti-TB drug regimen may be placed on directly observed
therapy (DOT). This means that an HCW must observe and validate patient
compliance with the drug regimen. DOT has been very effective at reducing the
spread of multidrug-resistant TB."
A nurse is teaching a patient starting TB medication therapy. Which
statements should be included? (Select all that apply)
, Page 3 of 81
A. "Take all medications exactly as prescribed for the full duration."
B. "You can stop when you feel better."
C. "Nausea is common and can be managed."
D. "Missing doses may lead to drug resistance."
E. "Sputum tests are needed every 4 weeks."
Answers: A, C, D, E
Rationale:
A - CORRECT: "Stress the importance of taking each drug regularly, exactly as
prescribed, for as long as it is prescribed"
C - CORRECT: "Drugs to treat TB often cause nausea" - manageable with timing
changes and antiemetics
D - CORRECT: "Not taking the drugs as prescribed could lead to a drug-resistant
infection"
E - CORRECT: "Sputum specimens are needed about every 4 weeks once drug
therapy is initiated"
B - INCORRECT: Never stop early; full duration essential
A patient taking rifampin for TB asks why their urine has turned orange. What
is the nurse's best response?
A. "This indicates liver damage; we need to stop the medication."
B. "This is an expected side effect of rifampin."
C. "You may be dehydrated; increase your fluid intake."
D. "This means the medication isn't working properly."
Answer: B - "This is an expected side effect of rifampin."
Rationale: Rifampin causes orange discoloration of body fluids (urine, tears, sweat,
saliva). This is a harmless, expected side effect. Patients should be counseled that
this will occur and may stain contact lenses and clothing. It does NOT indicate
toxicity or treatment failure.
A female patient taking rifampin for TB uses oral contraceptives for birth
control. What should the nurse teach?
A. Rifampin increases contraceptive effectiveness
B. Rifampin decreases contraceptive effectiveness
, Page 4 of 81
C. No interaction exists between these medications
D. Contraceptives should be stopped during TB treatment
Answer: B - Rifampin decreases contraceptive effectiveness
Rationale: Rifampin is a potent enzyme inducer that decreases effectiveness of oral
contraceptives, leading to potential contraceptive failure. Patients should use
alternative or additional birth control methods during rifampin therapy. This is a
critical drug interaction for women of childbearing age.
Which patient statement indicates understanding of rifampin therapy?
A. "I'll take this medication with antacids to prevent stomach upset."
B. "My soft contact lenses may become permanently stained."
C. "I can drink alcohol occasionally while on this medication."
D. "I should take this on a full stomach"
Answer: B - "My soft contact lenses may become permanently stained."
Rationale: Rifampin's orange discoloration affects tears and can permanently stain
soft contact lenses. Patients should avoid wearing them or switch to glasses during
treatment. Rifampin should be taken on an empty stomach (not with food/antacids).
Alcohol should be avoided due to hepatotoxicity risk.
A patient with newly diagnosed rheumatoid arthritis reports joint stiffness that
is worst in the morning. How long should the nurse explain this stiffness
typically lasts?
A. 15-30 minutes
B. 1-2 hours
C. Several hours
D. All day
Answer: C - Several hours
Rationale: The textbook states: "The patient usually has frequent morning stiffness,
which can last for several hours after awakening." This prolonged morning stiffness
is a hallmark symptom of RA and distinguishes it from osteoarthritis, where stiffness
typically resolves within 30 minutes.
A patient with RA suddenly develops one hot, swollen, extremely painful knee
that is out of proportion to their other joints. What is the nurse's priority
