NURS 5334 ANTIMICROBIALS
EXAMINATION STUDY GUIDE 2026
COMPLETE QUESTIONS AND ANSWERS
◉ Benzodiazepines.
Answer: drugs that lower anxiety and reduce stress
Lorazepam (Ativan)- avoid alcohol d/t respiratory depression
alprazolam (Xanax)
◉ Substance P/Neurokinin 1 Receptor Antagonist (-pitant).
Answer: usually given with dexamethason and 5-HT3 (zofran)
work well for late phase chemo N/V 24 hrs post infusion
Aprepitant
Fosaprepitant
Netupitant
Rolapitant
◉ Chloride Channel Activators.
Answer: Lubiprostone (Amitiza)
,- Pharmacodynamics: activates chloride channels in the GI epithelial
lining, producing chloride-rich secretions that soften the stool and
increase motility, causes little change in electrolytes.
No evidence of dependency or tolerance.
- Caution: bowel obstruction, pediatrics or pregnancy
- SE: HA, nausea, diarrhea, abd pain, bloating
◉ Crohn's Disease.
Answer: a chronic autoimmune disorder that can occur anywhere in
the digestive tract; however, it is most often found in the ileum and
in the colon, transmural inflammation
◉ Ulcerative Colitis.
Answer: a chronic condition of unknown cause in which repeated
episodes of inflammation in the rectum and large intestine cause
ulcers and irritation, continuous extending
◉ IBD.
Answer: Remission: 5-aminosalicylates (rectal or oral),
corticosteroids (rectal, oral, IV), TNF-a inhibitors, integrin inhibitors,
IL-12/23
, Maintain Remission: Azathioprine, 6-mercaptopuring and
methotrexate
◉ 5-Aminosalicylates (5-ASA).
Answer: anti-inflammatory and immunosuppressant
1st line treatment for mild-moderate UC
absorption increased with severe disease, decreased with lower pH.
PPI, H2B, antacids can cause increased systemic absorption before it
reaches site of action.
◉ Azo-prodrug.
Answer: inactive until it reaches the target site in the body. Used for
target therapy, especially in colon for IBD
◉ 5-ASA bound to Azo prodrug.
Answer: balsalazide
olsalazine
sulfasalazine- PROTO-oral monitor LFT, CBC, respiratory, renal, skin,
inhibits folate absorption
◉ Mesalamine (oral).
Answer: Single 5-ASA w/ enteric coating.
Asacol
EXAMINATION STUDY GUIDE 2026
COMPLETE QUESTIONS AND ANSWERS
◉ Benzodiazepines.
Answer: drugs that lower anxiety and reduce stress
Lorazepam (Ativan)- avoid alcohol d/t respiratory depression
alprazolam (Xanax)
◉ Substance P/Neurokinin 1 Receptor Antagonist (-pitant).
Answer: usually given with dexamethason and 5-HT3 (zofran)
work well for late phase chemo N/V 24 hrs post infusion
Aprepitant
Fosaprepitant
Netupitant
Rolapitant
◉ Chloride Channel Activators.
Answer: Lubiprostone (Amitiza)
,- Pharmacodynamics: activates chloride channels in the GI epithelial
lining, producing chloride-rich secretions that soften the stool and
increase motility, causes little change in electrolytes.
No evidence of dependency or tolerance.
- Caution: bowel obstruction, pediatrics or pregnancy
- SE: HA, nausea, diarrhea, abd pain, bloating
◉ Crohn's Disease.
Answer: a chronic autoimmune disorder that can occur anywhere in
the digestive tract; however, it is most often found in the ileum and
in the colon, transmural inflammation
◉ Ulcerative Colitis.
Answer: a chronic condition of unknown cause in which repeated
episodes of inflammation in the rectum and large intestine cause
ulcers and irritation, continuous extending
◉ IBD.
Answer: Remission: 5-aminosalicylates (rectal or oral),
corticosteroids (rectal, oral, IV), TNF-a inhibitors, integrin inhibitors,
IL-12/23
, Maintain Remission: Azathioprine, 6-mercaptopuring and
methotrexate
◉ 5-Aminosalicylates (5-ASA).
Answer: anti-inflammatory and immunosuppressant
1st line treatment for mild-moderate UC
absorption increased with severe disease, decreased with lower pH.
PPI, H2B, antacids can cause increased systemic absorption before it
reaches site of action.
◉ Azo-prodrug.
Answer: inactive until it reaches the target site in the body. Used for
target therapy, especially in colon for IBD
◉ 5-ASA bound to Azo prodrug.
Answer: balsalazide
olsalazine
sulfasalazine- PROTO-oral monitor LFT, CBC, respiratory, renal, skin,
inhibits folate absorption
◉ Mesalamine (oral).
Answer: Single 5-ASA w/ enteric coating.
Asacol
