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Summary DNA, Meiosis & Genetics - Grade 12 (CAPS)

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These are study notes for Grade 12 Life Sciences, written strictly according to the South African CAPS curriculum requirements. They are designed for quick revision or active recall. Contents Included: DNA: The Code of Life & RNA: Cell locations , nucleotide structure components, complementary base pairing, differences between DNA and RNA, steps of semi-conservative replication, and the full sequence of protein synthesis (Transcription and Translation). Meiosis: Chronological breakdowns of all phases in Meiosis I and II, mechanisms of genetic variation (crossing over and random arrangement), non-disjunction errors, and Down Syndrome (Trisomy 21). Includes a basic comparison table between mitosis and meiosis. Genetics and Inheritance: Core definitions and Mendel's laws. Step by step exam layouts for Monohybrid crosses, Dihybrid crosses, Incomplete dominance, Co-dominance, and Sex-linked traits (Hemophilia and Red-Green Color Blindness). Includes rules for interpreting pedigree charts. Mutations & Biotechnology: Differences between gene and chromosomal mutations. Summaries of cloning , genetic modification (insulin production), and stem cell research, along with the standard pros, cons, and ethical points tested in exams.

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Topic 1: DNA - The Code of Life

Deoxyribonucleic acid (DNA) is the molecule
that carries the genetic blueprint
for all living organisms.

,DNA is found in three main locations within a cell:

Nuclear DNA: Found inside the nucleus. It forms chromosomes and contains the
majority of the organism's genetic information.

Mitochondrial DNA (mtDNA): Found inside the mitochondria. Inherited exclusively
from the mother.

Chloroplast DNA: Found in the chloroplasts of plant cells.

, DNA is a polymer made up of monomers called nucleotides.
It is a double-stranded helix (looks like a twisted ladder).
Each nucleotide is made of three components:
A phosphate group.
A deoxyribose sugar molecule.
A nitrogenous base.
There are four nitrogenous bases in DNA, divided into two groups:
Purines: Adenine (A) and Guanine (G)
• Pyrimidines: Thymine (T) and Cytosine (C)
Complementary Base Pairing Rule: Adenine always pairs with Thymine (A=T)

and Guanine always pairs with Cytosine (G C) via weak hydrogen bonds.

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The Study Nook

Welcome to The Study Nook. ☕✨ Clean, straightforward notes built directly from the Grade 12 curriculum guidelines. I made these for my own exam prep to cut out textbook clutter and keep the focus on exactly what gets tested ... mandatory definitions, core processes, and required exam layouts. Practical resources for quick revision and active recall.

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