Ci es| Updated Rated A+ | NEW
informa on, transmission, replica on, varia on
four criteria gene c material must meet
Avery, MacLeod, McCarty Experiment
demonstrated that DNA is the gene c material because degrada on of DNA led to a cessa on
of bacterial transforma on
nucleo des
form repea ng units
strand
nucleo des linked to form this
double helix
two strands of DNA interact to form this
protein, DNA
chromosomes contain these
DNA, RNA
types of nucleic acids
phosphate group, pentose sugar, nitrogenous base
components of nucleo des
presence of OH group at 2' loca on
difference between DNA and RNA
uracil instead of thymine
RNA differs from DNA in that it uses
phosphodiester linkage
connects nucleo des together (5' carbon to 3' carbon)
, phosphates and sugar
backbone of nucleic acids
phosphate
5' end group
hydroxyl
3' end group
Linus Pauling
proposed alpha-helical structure for proteins, use of physics models
Franklin and Wilkins
x-ray diffrac on studies of DNA structure
Erwin Chargaff
base pairing
x-ray diffrac on
suggests helical structure, too wide for single-stranded helix, 10 base pairs per turn of helix
Watson and Ccrick
ball and s ck model, published descrip on of structure of DNA
DNA structure
two strands, base pairing, an parallel strands, 10 nucleo des per 360 degree turn
RNA structure
usually single-stranded, can be par ally double stranded, ter ary
chromosome
structures that contain the gene c material
bacteria chromosome
single circular
genome
comprises all the gene c material an organism possesses