Latest Edition (2026/2027)
High-Yield Rapid Review EXAM
This comprehensive PMHNP board-style practice exam contains 70 unique high-yield questions with
correct answers and detailed rationales. Topics include psychopharmacology, DSM-5 disorders,
psychotherapy, ethics, neurobiology, substance use disorders, lifespan psychiatry, and emergency
psychiatry.
1. A patient taking lithium develops coarse tremors, vomiting, and confusion.
What is the priority intervention?
Correct Answer: Hold lithium and obtain a serum lithium level.
Rationale: These findings suggest lithium toxicity. The medication should be withheld immediately
while serum levels and renal function are assessed.
2. Which neurotransmitter is most associated with schizophrenia positive
symptoms?
Correct Answer: Dopamine
Rationale: Excess dopamine activity in the mesolimbic pathway is strongly linked to hallucinations and
delusions.
3. Which medication is FDA-approved for bipolar depression?
Correct Answer: Quetiapine
Rationale: Quetiapine is approved for bipolar depression and can improve depressive symptoms without
excessive mood destabilization.
4. A patient on clozapine reports fever and sore throat. What should the
PMHNP do first?
Correct Answer: Order a CBC with differential.
Rationale: Clozapine can cause agranulocytosis. Immediate white blood cell and ANC evaluation is
necessary.
5. Which defense mechanism involves redirecting emotions to a safer target?
Correct Answer: Displacement
Rationale: Displacement occurs when emotions are transferred from the original source to a less
threatening target.
, 6. What is the first-line treatment for obsessive-compulsive disorder?