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Samenvatting Medicinale Chemie | KU Leuven | 2024/5

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structuren van medicinale chemie met telkens beschrijving wat het is dit studeren en vanbuiten kennen = erdoor op je examen ;)

Institution
Katholieke Universiteit Leuven (KU Leuven)
Course
Medicinale chemie

Content preview

Les2: producten die interfereren met DNA-functies en biosynthese
Mitose inhibitoren
a. Vinca alkaloïden
Vinblastine, vincristine, vindesine, navelbine




b. Eribuline




c. Taxanen
Paclitaxel




d. Colchicine




e. Podophyllotoxine

,Biosynthese vn nucleïnezuren
1. Metabolisme van bouwstenen voor nucleïnezuren
a. Indirecte inhibitie vn nucleotidesynthese (-> inwerken op cofactor)
i. Foliumzuur
->methotrexaat




->trimethoprim, pyrimethamine, proguanil




b. Directe inhibitie van nucleotidesynthese
i. Ribonucleotide reductase
->hydroxycarbamide




->nuceleoside-analogen: gemcitabine, fludarabinefosfaat




ii. Thymidylaat synthase
->pemetrexed




->5-fluorouracil

, iii. Inosinemonofosfaat dehydrogenase
->mycofenolaat




->ribavirine




c. Inhibitoren vn degradatie purinebasen
i. XO-inhibitoren
->allopurinol




->febuxostat

, Les3
2. DNA-transcriptie
a. Inhibitie vn polymerasen
i. RNA polymerasen
->ansamycine




->thiopurines
Thioguanine, mercaptopurine




ii. DNA-polymerasen
->cytosine arabinoside




->fludarabine, clofarabine, cladribine




b. Inhibitie vn topoisomerase
i. Topoisomerase1
Campothecin, topotecan, irinotecan




ii. Topoisomerase2
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Institution
Katholieke Universiteit Leuven (KU Leuven)
Study
Farmaceutische Wetenschappen
Course
Medicinale chemie

Document information

Uploaded on
May 29, 2026
Number of pages
58
Written in
2024/2025
Type
SUMMARY

Subjects

  • medicinale chemie
  • ku leuven
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