ADME EXAM QUESTIONS AND
ANSWERS
What does pharmacokinetics consist of? - Correct Answers -absorption, distribution,
metabolism, excretion
What determines how well a medication can cross the membrane? - Correct Answers -
smaller compounds can more more easily cros the cell membrane, lipophillicity
(uncharged nonpolar) is also an advantage
What may effect how uncharged molecules cross membranes? - Correct Answers -pH
Are most drugs strong or weak acids and bases? - Correct Answers -weak
Why can different drugs cross the barrier at different points in the body? - Correct
Answers -due to the pH of the environment
What are five major processes of absorption? - Correct Answers -passive diffusion, lipid
diffusion, aqueous diffusion, active transport, facilitated diffusion
What is passive diffusion rate proportional to? - Correct Answers -drug concentration
and surface area available
What are seven factors that affect oral absorption? - Correct Answers -disintegration of
dosage form, dissolution of particles, chemical stability of drug, stability of drug to
enzymes, presence and type of food, blood flow to GI tract, gastric emptying time
What is the primary site of absorption of oral drugs? - Correct Answers -small intestine
What is the result of liver metabolism? - Correct Answers -may reduce the bioavailability
of oral drugs
What are seven factors that affect drug absorption from the GI tract? - Correct Answers
-pH of GI contents, area of absorbing surface, concentration of dissolved drug, motility
of the GI tract, effects of first-pass metabolism, disorders of absorption, drug
interactions in GI tract
What are some routes of drug administration? - Correct Answers -intravenous,
parenteral (not through digestive system: i.v., i.m. s.c. etc), skin, lungs
ANSWERS
What does pharmacokinetics consist of? - Correct Answers -absorption, distribution,
metabolism, excretion
What determines how well a medication can cross the membrane? - Correct Answers -
smaller compounds can more more easily cros the cell membrane, lipophillicity
(uncharged nonpolar) is also an advantage
What may effect how uncharged molecules cross membranes? - Correct Answers -pH
Are most drugs strong or weak acids and bases? - Correct Answers -weak
Why can different drugs cross the barrier at different points in the body? - Correct
Answers -due to the pH of the environment
What are five major processes of absorption? - Correct Answers -passive diffusion, lipid
diffusion, aqueous diffusion, active transport, facilitated diffusion
What is passive diffusion rate proportional to? - Correct Answers -drug concentration
and surface area available
What are seven factors that affect oral absorption? - Correct Answers -disintegration of
dosage form, dissolution of particles, chemical stability of drug, stability of drug to
enzymes, presence and type of food, blood flow to GI tract, gastric emptying time
What is the primary site of absorption of oral drugs? - Correct Answers -small intestine
What is the result of liver metabolism? - Correct Answers -may reduce the bioavailability
of oral drugs
What are seven factors that affect drug absorption from the GI tract? - Correct Answers
-pH of GI contents, area of absorbing surface, concentration of dissolved drug, motility
of the GI tract, effects of first-pass metabolism, disorders of absorption, drug
interactions in GI tract
What are some routes of drug administration? - Correct Answers -intravenous,
parenteral (not through digestive system: i.v., i.m. s.c. etc), skin, lungs
