ADME PHARMACOKINETICS EXAM
QUESTIONS AND ANSWERS
Define pharmacokinetics - Correct Answers -Branch of pharmacology that studies what
*the body does to the drug* (the body is trying to get rid of the drug, as opposed to
pharmacodynamics, which studies what the drug does to the body (the drug is trying to
stay in the body)
define Absorption - Correct Answers -Movement of drug from administration site into
blood (central compartment)
define distribution - Correct Answers -Dispersion of drug into tissues
define metabolism (or biotransformation) - Correct Answers -irreversible transformation
of drugs into metabolites
role of xenobiotics metabolic pathways - Correct Answers -xenobiotics go through
phase I metabolism and then it must be *polar* to enter phase II metabolism, then the
polar molecule must be rendered hydrophilic so that it can be water soluble and enter
extracellular mobilization (kidney or bile can excrete the xenobiotic)
function of phase I metabolism - Correct Answers -to render drug molecules polar
function of phase II metabolism - Correct Answers -to render the polar drug molecules
hydrophilic
define excretion - Correct Answers -Removal of drugs from the body
define elimination - Correct Answers -disposition of drugs as a result of metabolism and
excretion
define liberation - Correct Answers -drug release from the formulation
Identify the factors that influence drug transport across membranes - Correct Answers -
1. physicochemical properties of drugs:
molecular size
chemical structure
degree of ionization
relative lipid solubility
protein binding
2. physicochemical properties of membranes
QUESTIONS AND ANSWERS
Define pharmacokinetics - Correct Answers -Branch of pharmacology that studies what
*the body does to the drug* (the body is trying to get rid of the drug, as opposed to
pharmacodynamics, which studies what the drug does to the body (the drug is trying to
stay in the body)
define Absorption - Correct Answers -Movement of drug from administration site into
blood (central compartment)
define distribution - Correct Answers -Dispersion of drug into tissues
define metabolism (or biotransformation) - Correct Answers -irreversible transformation
of drugs into metabolites
role of xenobiotics metabolic pathways - Correct Answers -xenobiotics go through
phase I metabolism and then it must be *polar* to enter phase II metabolism, then the
polar molecule must be rendered hydrophilic so that it can be water soluble and enter
extracellular mobilization (kidney or bile can excrete the xenobiotic)
function of phase I metabolism - Correct Answers -to render drug molecules polar
function of phase II metabolism - Correct Answers -to render the polar drug molecules
hydrophilic
define excretion - Correct Answers -Removal of drugs from the body
define elimination - Correct Answers -disposition of drugs as a result of metabolism and
excretion
define liberation - Correct Answers -drug release from the formulation
Identify the factors that influence drug transport across membranes - Correct Answers -
1. physicochemical properties of drugs:
molecular size
chemical structure
degree of ionization
relative lipid solubility
protein binding
2. physicochemical properties of membranes
