ASCP HEMATOLOGY FINAL PAPER 2026
FULL QUESTIONS AND CORRECT
ANSWERS
◉ Where does hematopoiesis take place during the first 2 months of
gestation?
Answer: yolk sac
◉ Where does the majority of hematopoiesis take place during the
2nd through 7th month of gestation?
Answer: spleen
◉ When does the bone marrow take over hematopoiesis?
Answer: after birth
◉ What are the stages in order of the erythrocyte lineage?
Answer: (1)rubriblast, (2)prorubricyte, (3)rubricyte,
(4)metarubricyte, (5)reticulocyte, (6)erytrocyte
◉ What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage?
,Answer: (1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
◉ What are the stages in order of the macrophage lineage?
Answer: (1)monoblast, (2)promonocyte, (3)monocyte,
(4)macrophage
◉ What are the stages in order of the platelet lineage?
Answer: (1)megakaryoblast, (2)promegakaryocyte,
(3)megakaryocyte, (4)platelet
◉ What are the stages in order of the lymphocyte lineage?
Answer: (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
◉ Which growth factors stimulate the erythrocyte lineage?
Answer: GM-CSF, EPO, IL-3
◉ Which growth factors stimulate the granulocyte lineages?
Answer: GM-CSF, IL-3
◉ Which growth factors stimulate the platelet lineage?
Answer: GM-CSF, IL-3, TPO
,◉ Which growth factors stimulate the lymphocyte lineage?
Answer: IL-2, IL-4, IL-6, IL-7
◉ Which protein functions in the transport of Fe?
Answer: transferrin
◉ What is the major storage form of Fe?
Answer: ferritin
◉ What is the long-term (H20) insoluble Fe storage form called?
Answer: hemosiderin
◉ Excess Iron is stored where? What does this cause?
Answer: tissues and body organs, hemosiderosis, hemochromatosis
◉ Porphyrias are attributed to?
Answer: excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
◉ Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors?
, Answer: porphyria
◉ Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs?
Answer: early precursors (Delta-aminolevulinic
acid/Porphobilinogen)
◉ Cutaneous symptoms such as photo-sensitivity and facial hair are
seen when a build up of which precursors occurs?
Answer: later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
◉ Synthesis of heme requires what two components?
Answer: iron, protoporphyrin
◉ What are the heme precursors in order of synthesis?
Answer: (1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin,
(6)heme
◉ What type of hemoglobin is seen primarily in newborns?
Answer: Hgb F
FULL QUESTIONS AND CORRECT
ANSWERS
◉ Where does hematopoiesis take place during the first 2 months of
gestation?
Answer: yolk sac
◉ Where does the majority of hematopoiesis take place during the
2nd through 7th month of gestation?
Answer: spleen
◉ When does the bone marrow take over hematopoiesis?
Answer: after birth
◉ What are the stages in order of the erythrocyte lineage?
Answer: (1)rubriblast, (2)prorubricyte, (3)rubricyte,
(4)metarubricyte, (5)reticulocyte, (6)erytrocyte
◉ What are the stages in order of the granulocyte (neutrophil,
eosinophil, basophil) lineage?
,Answer: (1)myeloblast, (2)promyelocyte, (3)myelocyte,
(4)metamyelocyte, (5)band, (6)segmented (7)eos/baso
◉ What are the stages in order of the macrophage lineage?
Answer: (1)monoblast, (2)promonocyte, (3)monocyte,
(4)macrophage
◉ What are the stages in order of the platelet lineage?
Answer: (1)megakaryoblast, (2)promegakaryocyte,
(3)megakaryocyte, (4)platelet
◉ What are the stages in order of the lymphocyte lineage?
Answer: (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
◉ Which growth factors stimulate the erythrocyte lineage?
Answer: GM-CSF, EPO, IL-3
◉ Which growth factors stimulate the granulocyte lineages?
Answer: GM-CSF, IL-3
◉ Which growth factors stimulate the platelet lineage?
Answer: GM-CSF, IL-3, TPO
,◉ Which growth factors stimulate the lymphocyte lineage?
Answer: IL-2, IL-4, IL-6, IL-7
◉ Which protein functions in the transport of Fe?
Answer: transferrin
◉ What is the major storage form of Fe?
Answer: ferritin
◉ What is the long-term (H20) insoluble Fe storage form called?
Answer: hemosiderin
◉ Excess Iron is stored where? What does this cause?
Answer: tissues and body organs, hemosiderosis, hemochromatosis
◉ Porphyrias are attributed to?
Answer: excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
◉ Red or port wine colored urine can be seen in which condition
related to the build up of heme precursors?
, Answer: porphyria
◉ Neuropsychiatirc symptoms are seen when a build up of which
precursors occurs?
Answer: early precursors (Delta-aminolevulinic
acid/Porphobilinogen)
◉ Cutaneous symptoms such as photo-sensitivity and facial hair are
seen when a build up of which precursors occurs?
Answer: later precursors (uroporphyrinogen/coproporphyrinogen,
protoporphyrin/heme)
◉ Synthesis of heme requires what two components?
Answer: iron, protoporphyrin
◉ What are the heme precursors in order of synthesis?
Answer: (1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin,
(6)heme
◉ What type of hemoglobin is seen primarily in newborns?
Answer: Hgb F
