(2026 Expert-Verified Final
Exam Q & A )
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, Anti-Ulcer drugs help by: -altering gastric pH by decreasing acid secretion
-protecting the stomach wall lining by increasing mucosal protection
-eradicating harmful bacteria Ex: H. Pylori
What are the main pharmacologic categories of drugs we -antacids
used to manage gastric acid secretion and the effects: -H2 receptor antagonists
-proton pump inhibitors (PPIs)
-prostoglandin analogs
-mucosal protectant sulcrafate (Carafate)
What is the first OTC medication tried by patients with -Antacids
dyspepsia?
-->these are typically not effective for persistant GERD and PUD
What are antacids? How do they work? -organic salts
-neutralize the hydrochloric acid in the stomach
-raises the gastric pH above 4.0
What are the main side effects of antacids? -diarrhea
-constipation
What are the different categories of antacids? -calcium carbonate
-sodium bicarbonate
-aluminum based
-magnesium based
-aluminum hydroxide
What is important teaching for patients taking antacids? -decreasing the stomach pH can cause the decrease absorption of drugs that rely
on acidic conditions
-if taking enteric coated medications--reducing stomach acid can cause the
medication to dissolve and absorb in the stomach instead of the intestine
*always separate antacids from other medications by 2 hours*
Calcium carbonate antacids: -Tums
-can cause CONSTIPATION
-require adequate fluid intake to dissolve
-can be used in patients needing to take an antacid who also could benefit from
extra calcium intake. -potential for milk "alkali" syndrome, metabolic alkalosis
Sodium Bicarbonate antacids: -Alka Seltzer
-contains aspirin (ASA)
-potential to WORSEN GI distress. -increased risk for water retention and fluid
overload
-potential to cause hypertension
-Contraindicated in pregnancy, children, patient with CVD*
Aluminum based antacids: -Amphogel
-can cause CONSTIPATION
-requires adequate fluid intake to dissolve
-Contraindicated in patients with renal insufficiency*
Magnesium based antacids: -Milk of magnesia
-suspension mixture is more effective
-can cause DIARRHEA
-Contraindicated in renal insufficiency*
Aluminum hydroxide antacids: -may decrease the absorption of warfarin*. -can cause a chelating affect with drugs
such as tetracyclines, warfarin, and digoxin—potentially decreasing their absorption
& effectiveness -high affinity for phosphate—may cause hypophasphatemia
What can cause heartburn in pregnancy? -hormonal fluctuations
-anatomic changes
2026