AGACNP – Hematology Questions and Answers

AGACNP – Hematology Questions and Answers What causes Pernicious anemia? a deficiency of intrinsic factor, which results in malabsorption of B12 Neurological symptoms are associated with which type of anemia? Pernicious Lymphoma Stage I Disease localized to single lymph node or group Lymphoma Stage II more than one lymph node group is involved and confined to one side of the diaphragm, such as the lymph nodes of the neck and the tonsils Lymphoma Stage III cancer has spread to both sides of the diaphragm Lymphoma Stage IV cancer has spread to one or more organs beyond the lymph nodes How is lymphoma diagnosed? by biopsy of enlarged lymph nodes Non-Hodgkin's Lymphoma cancer of the lymphatic tissues less predictable spread common neoplasm b/t ages 20 and 40 yrs old Hodgkin's lymphoma Males; 30's (32) cervical adenopathy spread is predictable Reed-sternberg cells Reed-Sternberg cells Hodgkin's lymphoma Leukemia cancer of white blood cells neoplasms arising from hematopoietic cells in bone marrow hematopoietic cells blood forming stem cells Acute Nonlymphocytic Leukemia (ANL) Acute Myelogenous Leukemia (AML) 80% of acute leukemia in adults Acute Lymphocytic Leukemia (ALL) Pancytopenia (all labs down) with circulating blasts (hallmark of disease) More difficult to cure in adults than children Chronic Lymphocytic Leukemia (CLL) Most common leukemia in adults Lymphocytosis (hallmark of disease) 42,000 WBC Median survival is 10 years An 80-year-old man presents with fatigue, lymphadenopathy, splenomegaly, and isolated lymphocytosis. Suspected leukemia diagnosis? Chronic Lymphocytic Leukemia CLL Hallmark lymphocytic leukemia Chronic Myelogenous Leukemia (CML) PHILADELPHIA chromosome Peripheral blood smear usually distinguishes acute and chronic leukemia but a __________ is required to confirm diagnosis. bone marrow aspiration Initiate ____________ to reduce tumor lysis syndrome in high risk patients allopurinol