10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
tg tg tg tg tg tg tg 1
Chapter 02 Cells and Tissues of the Immune System
tg tg tg tg tg tg tg tg 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
tg tg tg tg tg tg tg 6
Chapter 04 Innate Immunity
tg tg tg 10
Chapter 05 Antibodies and Antigens
tg tg tg tg 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
tg t g 20
Chapter 07 Immune Receptors and Signal Transduction
tg tg tg tg tg tg 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
tg tg tg tg tg tg tg tg 30
Chapter 09 Activation of T Lymphocytes
tg tg tg tg t g 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
tg tg tg tg tg tg tg tg tg 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
tg tg tg tg tg tg tg tg tg 42
Chapter 12 B Cell Activation and Antibody Production
tg tg tg tg tg tg tg 46
Chapter 13 Effector Mechanisms of Humoral Immunity
tg tg tg tg tg tg 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
tg tg tg tg tg tg tg tg tg tg tg 56
Chapter 15 Immunologic Tolerance and Autoimmunity
tg tg tg tg tg 62
Chapter 16 Immunity to Microbes
tg t g tg t g 67
Chapter 17 Transplantation Immunology
tg tg t g 72
Chapter 18 Tumor Immunology
tg tg t g 77
Chapter 19 Hypersensitivity Disorders
tg tg tg 81
Chapter 20 Allergy
tg tg 86
Chapter 21 Primary and Acquired Immunodeficiencies
tg tg tg tg t g 89
,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
tg tg tg tg tg tg tg tg tg
MULTIPLE CHOICE tg
1. The principal function of the immune system is:
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a. Defense against cancer tg tg
b. Repair of injured tissues tg tg tg
c. Defense against microbial infections tg tg tg
d. Prevention of inflammatory diseases tg tg tg
e. Protection against environmental toxins tg tg tg
ANS: C
The immune system has evolved in the setting of selective pressures imposed by microbi al
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
infections. Although immune responses to cancer may occur, the concept that “immun osurv
tg tg tg tg tg tg tg tg tg tg tg tg
eillance” against cancer is a principal function of the immune system is controversi al. Repai
tg tg tg tg tg tg tg tg tg tg tg tg t g tg
r of injured tissues may be a secondary consequence of the immune responses a nd inflamm
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
ation. Although the immune system has regulatory features that are needed to prevent excessi
tg tg tg tg tg tg tg tg tg tg tg tg tg
ve inflammation, prevention of inflammatory diseases is not a primary fu nction. The immun
tg tg tg tg tg tg tg tg tg tg tg tg tg
e system can protect against microbial toxins, but it generally does not offer protection again
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
st toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successf ul
tg tg tg tg tg tg tg tg tg tg tg tg t
vaccination?
g
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a gai
tg tg tg tg tg tg tg tg tg tg tg tg t g
nst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective vac
tg tg tg tg tg tg tg tg tg tg tg tg t g
cines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c entury
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
and are widely used. There is no effective vaccine against Mycobacterium tuberc ulosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens tg tg tg tg tg tg
b. Self-nonself discrimination tg
c. Recognition of microbial structures by both cell-associated and soluble receptors tg tg tg tg tg tg tg tg tg
d. Protection against viral infections tg tg tg
e. Responses that have the same kinetics and magnitude on repeated exposure to t he tg tg tg tg tg tg tg tg tg tg tg tg tg
same microbe tg tg
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho cyte
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
s, which are the central cellular components of the adaptive immune system. Both th e in
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
nate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
tg tg tg t g t g tg t g t g t g tg tg
nonself discrimination, and protect against viruses. On repeated exposure to the same mi cro
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be, the adaptive immune response becomes more rapid and of greater magnitude; this is th
tg tg tg tg tg tg tg tg tg tg tg tg t g tg
e manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
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a. Innate and adaptive tg tg
b. Passive and active tg tg
c. Specific and nonspecific tg tg
d. Humoral and cell-mediated tg tg
e. Adult and neonatal tg tg
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyt
tg tg tg tg tg tg tg tg tg tg tg tg
e s produce antibodies, which are the recognition and effector molecules of humoral imm
tg tg tg tg tg tg tg tg tg tg tg tg tg
un e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
ellular pathogens in cell- tg tg tg
mediated immunity. Passive and active immunity both can be mediated by either B or T ly m
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp hocy
tg tg tg tg tg tg tg tg tg tg tg tg tg t g
tes participate in adult adaptive immunity but are still developing in the neonatal peri od.
tg tg tg tg tg tg tg tg tg tg tg tg tg t g
5. The two major functional classes of effector T lymphocytes are:
tg tg tg tg tg tg tg tg tg
a. Helper T lymphocytes and cytotoxic T lymphocytes tg tg tg tg tg tg
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes tg tg tg tg
c. Memory T cells and effector T cells tg tg tg tg tg tg
d. Helper cells and antigen-presenting cells tg tg tg tg
e. Cytotoxic T lymphocytes and target cells tg tg tg tg tg
ANS: A
T cells can be classified into effector subsets that perform different effector functions. Mo st
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
effector T cells are either helper T lymphocytes, which enhance the responses of other immu
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
ne cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt es, whic
tg tg tg tg tg tg tg tg tg tg tg tg t g t g
h directly kill infected cells. Natural killer cells are not T lymphocytes.
t g t g t g t g t g t g t g t g t g t g t g
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. tg tg tg tg tg tg tg tg tg tg tg tg tg tg
6. Which of the following cell types is required for all adaptive humoral immune responses?
tg tg tg tg tg tg tg tg tg tg tg tg tg
a. Natural killer cells tg tg
b. Dendritic cells tg
c. Cytolytic T lymphocytes tg tg
d. B lymphocytes tg
e. Helper T lymphocytes tg tg
ANS: D
Humoral immune responses are antibody- tg tg tg tg
mediated immune responses, and all antibodies are made by B lymphocytes and no oth er
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
cell type. tg
tg
,Table of Contents
tg tg
Chapter 01 Properties and Overview of Immune Responses
tg tg tg tg tg tg tg 1
Chapter 02 Cells and Tissues of the Immune System
tg tg tg tg tg tg tg tg 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
tg tg tg tg tg tg tg 6
Chapter 04 Innate Immunity
tg tg tg 10
Chapter 05 Antibodies and Antigens
tg tg tg tg 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
tg tg tg tg tg tg tg tg tg tg tg
Histocompatibility Complex Molecules
tg t g 20
Chapter 07 Immune Receptors and Signal Transduction
tg tg tg tg tg tg 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
tg tg tg tg tg tg tg tg 30
Chapter 09 Activation of T Lymphocytes
tg tg tg tg t g 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
tg tg tg tg tg tg tg tg tg 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
tg tg tg tg tg tg tg tg tg 42
Chapter 12 B Cell Activation and Antibody Production
tg tg tg tg tg tg tg 46
Chapter 13 Effector Mechanisms of Humoral Immunity
tg tg tg tg tg tg 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
tg tg tg tg tg tg tg tg tg tg tg 56
Chapter 15 Immunologic Tolerance and Autoimmunity
tg tg tg tg tg 62
Chapter 16 Immunity to Microbes
tg t g tg t g 67
Chapter 17 Transplantation Immunology
tg tg t g 72
Chapter 18 Tumor Immunology
tg tg t g 77
Chapter 19 Hypersensitivity Disorders
tg tg tg 81
Chapter 20 Allergy
tg tg 86
Chapter 21 Primary and Acquired Immunodeficiencies
tg tg tg tg t g 89
,Chapter 01: Properties and Overview of Immune Responses
tg tg tg tg tg tg tg
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
tg tg tg tg tg tg tg tg tg
MULTIPLE CHOICE tg
1. The principal function of the immune system is:
tg tg tg tg tg tg tg
a. Defense against cancer tg tg
b. Repair of injured tissues tg tg tg
c. Defense against microbial infections tg tg tg
d. Prevention of inflammatory diseases tg tg tg
e. Protection against environmental toxins tg tg tg
ANS: C
The immune system has evolved in the setting of selective pressures imposed by microbi al
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
infections. Although immune responses to cancer may occur, the concept that “immun osurv
tg tg tg tg tg tg tg tg tg tg tg tg
eillance” against cancer is a principal function of the immune system is controversi al. Repai
tg tg tg tg tg tg tg tg tg tg tg tg t g tg
r of injured tissues may be a secondary consequence of the immune responses a nd inflamm
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
ation. Although the immune system has regulatory features that are needed to prevent excessi
tg tg tg tg tg tg tg tg tg tg tg tg tg
ve inflammation, prevention of inflammatory diseases is not a primary fu nction. The immun
tg tg tg tg tg tg tg tg tg tg tg tg tg
e system can protect against microbial toxins, but it generally does not offer protection again
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
st toxins of nonbiologic origin.
tg tg tg tg
2. Which of the following infectious diseases was prevented by the first successf ul
tg tg tg tg tg tg tg tg tg tg tg tg t
vaccination?
g
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a gai
tg tg tg tg tg tg tg tg tg tg tg tg t g
nst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective vac
tg tg tg tg tg tg tg tg tg tg tg tg t g
cines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c entury
tg tg tg tg tg tg tg tg tg tg tg tg tg t g tg
and are widely used. There is no effective vaccine against Mycobacterium tuberc ulosis.
tg tg tg tg tg tg tg tg tg tg tg tg
3. Which of the following is a unique property of the adaptive immune system?
tg tg tg tg tg tg tg tg tg tg tg tg
a. Highly diverse repertoire of specificities for antigens tg tg tg tg tg tg
b. Self-nonself discrimination tg
c. Recognition of microbial structures by both cell-associated and soluble receptors tg tg tg tg tg tg tg tg tg
d. Protection against viral infections tg tg tg
e. Responses that have the same kinetics and magnitude on repeated exposure to t he tg tg tg tg tg tg tg tg tg tg tg tg tg
same microbe tg tg
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho cyte
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
s, which are the central cellular components of the adaptive immune system. Both th e in
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
nate and the adaptive immune systems use cell-
tg tg tg tg tg tg tg
associated and soluble receptors to recognize microbes, display some degree of self-
tg tg tg t g t g tg t g t g t g tg tg
nonself discrimination, and protect against viruses. On repeated exposure to the same mi cro
tg tg tg tg tg tg tg tg tg tg tg tg tg
be, the adaptive immune response becomes more rapid and of greater magnitude; this is th
tg tg tg tg tg tg tg tg tg tg tg tg t g tg
e manifestation of memory.
tg tg tg
4. Antibodies and T lymphocytes are the respective mediators of which two types of
tg tg tg tg tg tg tg tg tg tg tg tg
immunity?
tg
a. Innate and adaptive tg tg
b. Passive and active tg tg
c. Specific and nonspecific tg tg
d. Humoral and cell-mediated tg tg
e. Adult and neonatal tg tg
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyt
tg tg tg tg tg tg tg tg tg tg tg tg
e s produce antibodies, which are the recognition and effector molecules of humoral imm
tg tg tg tg tg tg tg tg tg tg tg tg tg
un e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
ellular pathogens in cell- tg tg tg
mediated immunity. Passive and active immunity both can be mediated by either B or T ly m
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
phocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp hocy
tg tg tg tg tg tg tg tg tg tg tg tg tg t g
tes participate in adult adaptive immunity but are still developing in the neonatal peri od.
tg tg tg tg tg tg tg tg tg tg tg tg tg t g
5. The two major functional classes of effector T lymphocytes are:
tg tg tg tg tg tg tg tg tg
a. Helper T lymphocytes and cytotoxic T lymphocytes tg tg tg tg tg tg
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes tg tg tg tg
c. Memory T cells and effector T cells tg tg tg tg tg tg
d. Helper cells and antigen-presenting cells tg tg tg tg
e. Cytotoxic T lymphocytes and target cells tg tg tg tg tg
ANS: A
T cells can be classified into effector subsets that perform different effector functions. Mo st
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
effector T cells are either helper T lymphocytes, which enhance the responses of other immu
tg tg tg tg tg tg tg tg tg tg tg tg tg tg
ne cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt es, whic
tg tg tg tg tg tg tg tg tg tg tg tg t g t g
h directly kill infected cells. Natural killer cells are not T lymphocytes.
t g t g t g t g t g t g t g t g t g t g t g
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. tg tg tg tg tg tg tg tg tg tg tg tg tg tg
6. Which of the following cell types is required for all adaptive humoral immune responses?
tg tg tg tg tg tg tg tg tg tg tg tg tg
a. Natural killer cells tg tg
b. Dendritic cells tg
c. Cytolytic T lymphocytes tg tg
d. B lymphocytes tg
e. Helper T lymphocytes tg tg
ANS: D
Humoral immune responses are antibody- tg tg tg tg
mediated immune responses, and all antibodies are made by B lymphocytes and no oth er
tg tg tg tg tg tg tg tg tg tg tg tg tg tg tg
cell type. tg
