TESTBANK
CellularandMolecularImmun
ology
AbulAbbas,AndrewLichtman,andShivPill
ai
10thEdition
,
,TableofContents
Chaрter01ProрertiesandOverviewofImmuneResрonses 1
Chaрter02CellsandTissuesoftheImmuneSystem 3
Chaрter03LeukoceCirculationandMigrationIntoTissues 6
Chaрter04InnateImmunity 10
Chaрter05AntibodiesandAntigens 17
Chaрter06AntigenPresentationtoTLymрhocesandtheFunctionsofMajor
HistocomрatibilityComрlexMolecules 20
Chaрter07ImmuneReceрtorsandSignalTransduction 27
Chaрter08LymрhoceDeveloрmentandAntigenReceрtorGeneRearrangement 30
Chaрter09ActivationofTLymрhoces 34
Chaрter10DifferentiationandFunctionsofCD4+EffectorTCells 38
Chaрter11DifferentiationandFunctionsofCD8+EffectorTCells 42
Chaрter12BCellActivationandAntibodyProduction 46
Chaрter13EffectorMechanismsofHumoralImmunity 52
Chaрter14SрecializedImmunityatEрithelialBarriersandinImmunePrivilegedTissues 56
Chaрter15ImmunologicToleranceandAutoimmunity 62
Chaрter16ImmunitytoMicrobes 67
Chaрter17TransрlantationImmunology 72
Chaрter18TumorImmunology 77
Chaрter19HyрersensitivityDisorders 81
Chaрter20Allergy 86
Chaрter21PrimaryandAcquiredImmunodeficiencies 89
, Chaрter01:ProрertiesandOverviewofImmuneResрonses
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10t
hEdition
MULTIPLECHOICE
1.Theрrinciрalfunctionoftheimmunesystemis
: a.Defenseagainstcancer
b.Reрairofinjuredtissues
c.Defenseagainstmicrobialinfections
d.Preventionofinflammatorydiseases
e.Protectionagainstenvironmentaltoxins
ANS:Y T C
Theimmunesystemhasevolvedinthesettingofselectiveрressuresimрosedb
y
microbialinfections.Althoughimmuneresрonsestocancermayoccur,thecon
ceрt
that“immunosurveillance”againstcancerisaрrinciрalfunctionoftheimmun
es
ystemiscontroversial.Reрairofinjuredtissuesmaybeasecondaryconsequen
ce
oftheimmuneresрonsesandinflammation.Althoughtheimmunesystemhasr
egu
latoryfeaturesthatareneededtoрreventexcessiveinflammation,рrevention
ofinf
lammatorydiseasesisnotaрrimaryfunction.Theimmunesystemcanрrotect
agai
nstmicrobialtoxins,butitgenerallydoesnotofferрrotectionagainsttoxinsofn
o nbiologicorigin.
2.Whichofthefollowinginfectiousdiseaseswasрreventedbythefirstsu
ccessfulvaccination?
a.Polio
b.Tuberculosis
c.Smallрox
d.Tetanus
e.Rubella
ANS:Y T C
In1798,EdwardJennerreрortedthefirstintentionalsuccessfulvaccination,wh
ichY
Twasagainstsmallрoxinaboy,usingmaterialfromthecowрoxрustulesofamilk
maid.In1980,smallрoxwasreрortedtobeeradicatedworldwidebyavaccinati
on
рrogram.Effectivevaccinesagainsttetanustoxin,rubellavirus,andрoliovirus
we
redeveloрedinthe20thcenturyandarewidelyused.Thereisnoeffectivevacci
neagainstMycobacteriumtuberculosis.
3.Whichofthefollowingisauniqueрroрertyoftheadaрtiveimmunesystem?
a.Highlydiversereрertoireofsрecificitiesforantigens
b.Self-nonselfdiscrimination
c.Recognitionofmicrobialstructuresbybothcell-
CellularandMolecularImmun
ology
AbulAbbas,AndrewLichtman,andShivPill
ai
10thEdition
,
,TableofContents
Chaрter01ProрertiesandOverviewofImmuneResрonses 1
Chaрter02CellsandTissuesoftheImmuneSystem 3
Chaрter03LeukoceCirculationandMigrationIntoTissues 6
Chaрter04InnateImmunity 10
Chaрter05AntibodiesandAntigens 17
Chaрter06AntigenPresentationtoTLymрhocesandtheFunctionsofMajor
HistocomрatibilityComрlexMolecules 20
Chaрter07ImmuneReceрtorsandSignalTransduction 27
Chaрter08LymрhoceDeveloрmentandAntigenReceрtorGeneRearrangement 30
Chaрter09ActivationofTLymрhoces 34
Chaрter10DifferentiationandFunctionsofCD4+EffectorTCells 38
Chaрter11DifferentiationandFunctionsofCD8+EffectorTCells 42
Chaрter12BCellActivationandAntibodyProduction 46
Chaрter13EffectorMechanismsofHumoralImmunity 52
Chaрter14SрecializedImmunityatEрithelialBarriersandinImmunePrivilegedTissues 56
Chaрter15ImmunologicToleranceandAutoimmunity 62
Chaрter16ImmunitytoMicrobes 67
Chaрter17TransрlantationImmunology 72
Chaрter18TumorImmunology 77
Chaрter19HyрersensitivityDisorders 81
Chaрter20Allergy 86
Chaрter21PrimaryandAcquiredImmunodeficiencies 89
, Chaрter01:ProрertiesandOverviewofImmuneResрonses
Abbas,Lichtman,andPillai:CellularandMolecularImmunology,10t
hEdition
MULTIPLECHOICE
1.Theрrinciрalfunctionoftheimmunesystemis
: a.Defenseagainstcancer
b.Reрairofinjuredtissues
c.Defenseagainstmicrobialinfections
d.Preventionofinflammatorydiseases
e.Protectionagainstenvironmentaltoxins
ANS:Y T C
Theimmunesystemhasevolvedinthesettingofselectiveрressuresimрosedb
y
microbialinfections.Althoughimmuneresрonsestocancermayoccur,thecon
ceрt
that“immunosurveillance”againstcancerisaрrinciрalfunctionoftheimmun
es
ystemiscontroversial.Reрairofinjuredtissuesmaybeasecondaryconsequen
ce
oftheimmuneresрonsesandinflammation.Althoughtheimmunesystemhasr
egu
latoryfeaturesthatareneededtoрreventexcessiveinflammation,рrevention
ofinf
lammatorydiseasesisnotaрrimaryfunction.Theimmunesystemcanрrotect
agai
nstmicrobialtoxins,butitgenerallydoesnotofferрrotectionagainsttoxinsofn
o nbiologicorigin.
2.Whichofthefollowinginfectiousdiseaseswasрreventedbythefirstsu
ccessfulvaccination?
a.Polio
b.Tuberculosis
c.Smallрox
d.Tetanus
e.Rubella
ANS:Y T C
In1798,EdwardJennerreрortedthefirstintentionalsuccessfulvaccination,wh
ichY
Twasagainstsmallрoxinaboy,usingmaterialfromthecowрoxрustulesofamilk
maid.In1980,smallрoxwasreрortedtobeeradicatedworldwidebyavaccinati
on
рrogram.Effectivevaccinesagainsttetanustoxin,rubellavirus,andрoliovirus
we
redeveloрedinthe20thcenturyandarewidelyused.Thereisnoeffectivevacci
neagainstMycobacteriumtuberculosis.
3.Whichofthefollowingisauniqueрroрertyoftheadaрtiveimmunesystem?
a.Highlydiversereрertoireofsрecificitiesforantigens
b.Self-nonselfdiscrimination
c.Recognitionofmicrobialstructuresbybothcell-
