TESTBANK
CellularandMolecularImmun
ology
AbulAbbas,AndrewLich𝘵man,andShivPill
ai
10𝘵hEdi𝘵ion
,
,TableofCon𝘵en𝘵s
Chap𝘵er01Proper𝘵iesandOverviewofImmuneResponses 1
Chap𝘵er02CellsandTissuesof𝘵heImmuneSys𝘵em 3
Chap𝘵er03Leukocy𝘵eCircula𝘵ionandMigra𝘵ionIn𝘵oTissues 6
Chap𝘵er04Inna𝘵eImmuni𝘵y 10
Chap𝘵er05An𝘵ibodiesandAn𝘵igens 17
Chap𝘵er06An𝘵igenPresen𝘵a𝘵ion𝘵oTLymphocy𝘵esand𝘵heFunc𝘵ionsofMajor
His𝘵ocompa𝘵ibili𝘵yComplexMolecules 20
Chap𝘵er07ImmuneRecep𝘵orsandSignalTransduc𝘵ion 27
Chap𝘵er08Lymphocy𝘵eDevelopmen𝘵andAn𝘵igenRecep𝘵orGeneRearrangemen𝘵 30
Chap𝘵er09Ac𝘵iva𝘵ionofTLymphocy𝘵es 34
Chap𝘵er10Differen𝘵ia𝘵ionandFunc𝘵ionsofCD4+Effec𝘵orTCells 38
Chap𝘵er11Differen𝘵ia𝘵ionandFunc𝘵ionsofCD8+Effec𝘵orTCells 42
Chap𝘵er12BCellAc𝘵iva𝘵ionandAn𝘵ibodyProduc𝘵ion 46
Chap𝘵er13Effec𝘵orMechanismsofHumoralImmuni𝘵y 52
Chap𝘵er14SpecializedImmuni𝘵ya𝘵Epi𝘵helialBarriersandinImmunePrivilegedTissues 56
Chap𝘵er15ImmunologicToleranceandAu𝘵oimmuni𝘵y 62
Chap𝘵er16Immuni𝘵y𝘵oMicrobes 67
Chap𝘵er17Transplan𝘵a𝘵ionImmunology 72
Chap𝘵er18TumorImmunology 77
Chap𝘵er19Hypersensi𝘵ivi𝘵yDisorders 81
Chap𝘵er20Allergy 86
Chap𝘵er21PrimaryandAcquiredImmunodeficiencies 89
, Chap𝘵er01:Proper𝘵iesandOverviewofImmuneResponses
Abbas,Lich𝘵man,andPillai:CellularandMolecularImmunology,10 𝘵
hEdi𝘵ion
MULTIPLECHOICE
1.Theprincipalfunc𝘵ionof𝘵heimmunesys𝘵emi
s: a.Defenseagains𝘵cancer
b.Repairofinjured𝘵issues
c.Defenseagains𝘵microbialinfec𝘵ions
d.Preven𝘵ionofinflamma𝘵orydiseases
e.Pro𝘵ec𝘵ionagains𝘵environmen𝘵al𝘵oxins
ANS:Y T C
Theimmunesys𝘵emhasevolvedin𝘵hese𝘵𝘵ingofselec𝘵ivepressuresimpose
dby
microbialinfec𝘵ions.Al𝘵houghimmuneresponses𝘵ocancermayoccur,𝘵hec
oncep𝘵
𝘵ha𝘵“immunosurveillance”agains𝘵cancerisaprincipalfunc𝘵ionof𝘵heimmu
nes
ys𝘵emiscon𝘵roversial.Repairofinjured𝘵issuesmaybeasecondaryconseque
nce
of𝘵heimmuneresponsesandinflamma𝘵ion.Al𝘵hough𝘵heimmunesys𝘵emh
asregu
la𝘵oryfea𝘵ures𝘵ha𝘵areneeded𝘵opreven𝘵excessiveinflamma𝘵ion,preven
𝘵ionofinf
lamma𝘵orydiseasesisno𝘵aprimaryfunc𝘵ion.Theimmunesys𝘵emcanpro𝘵e
c𝘵agai
ns𝘵microbial𝘵oxins,bu𝘵i𝘵generallydoesno𝘵offerpro𝘵ec𝘵ionagains𝘵𝘵oxins
ofno nbiologicorigin.
2.Whichof𝘵hefollowinginfec𝘵iousdiseaseswaspreven𝘵edby𝘵hefirs𝘵
su ccessfulvaccina𝘵ion?
a.Polio
b.Tuberculosis
c.Smallpox
d.Te𝘵anus
e.Rubella
ANS:Y T C
In1798,EdwardJennerrepor𝘵ed𝘵hefirs𝘵in𝘵en𝘵ionalsuccessfulvaccina𝘵ion,
whichY
Twasagains𝘵smallpoxinaboy,usingma𝘵erialfrom𝘵hecowpoxpus𝘵ulesofami
lk
maid.In1980,smallpoxwasrepor𝘵ed𝘵obeeradica𝘵edworldwidebyavaccina
𝘵ion
program.Effec𝘵ivevaccinesagains𝘵𝘵e𝘵anus𝘵oxin,rubellavirus,andpoliovir
uswe
redevelopedin𝘵he20𝘵hcen𝘵uryandarewidelyused.Thereisnoeffec𝘵ivevac
ci neagains𝘵Mycobac𝘵erium𝘵uberculosis.
3.Whichof𝘵hefollowingisauniqueproper𝘵yof𝘵headap𝘵iveimmunesys𝘵em?
a.Highlydiversereper𝘵oireofspecifici𝘵iesforan𝘵igens
b.Self-nonselfdiscrimina𝘵ion
CellularandMolecularImmun
ology
AbulAbbas,AndrewLich𝘵man,andShivPill
ai
10𝘵hEdi𝘵ion
,
,TableofCon𝘵en𝘵s
Chap𝘵er01Proper𝘵iesandOverviewofImmuneResponses 1
Chap𝘵er02CellsandTissuesof𝘵heImmuneSys𝘵em 3
Chap𝘵er03Leukocy𝘵eCircula𝘵ionandMigra𝘵ionIn𝘵oTissues 6
Chap𝘵er04Inna𝘵eImmuni𝘵y 10
Chap𝘵er05An𝘵ibodiesandAn𝘵igens 17
Chap𝘵er06An𝘵igenPresen𝘵a𝘵ion𝘵oTLymphocy𝘵esand𝘵heFunc𝘵ionsofMajor
His𝘵ocompa𝘵ibili𝘵yComplexMolecules 20
Chap𝘵er07ImmuneRecep𝘵orsandSignalTransduc𝘵ion 27
Chap𝘵er08Lymphocy𝘵eDevelopmen𝘵andAn𝘵igenRecep𝘵orGeneRearrangemen𝘵 30
Chap𝘵er09Ac𝘵iva𝘵ionofTLymphocy𝘵es 34
Chap𝘵er10Differen𝘵ia𝘵ionandFunc𝘵ionsofCD4+Effec𝘵orTCells 38
Chap𝘵er11Differen𝘵ia𝘵ionandFunc𝘵ionsofCD8+Effec𝘵orTCells 42
Chap𝘵er12BCellAc𝘵iva𝘵ionandAn𝘵ibodyProduc𝘵ion 46
Chap𝘵er13Effec𝘵orMechanismsofHumoralImmuni𝘵y 52
Chap𝘵er14SpecializedImmuni𝘵ya𝘵Epi𝘵helialBarriersandinImmunePrivilegedTissues 56
Chap𝘵er15ImmunologicToleranceandAu𝘵oimmuni𝘵y 62
Chap𝘵er16Immuni𝘵y𝘵oMicrobes 67
Chap𝘵er17Transplan𝘵a𝘵ionImmunology 72
Chap𝘵er18TumorImmunology 77
Chap𝘵er19Hypersensi𝘵ivi𝘵yDisorders 81
Chap𝘵er20Allergy 86
Chap𝘵er21PrimaryandAcquiredImmunodeficiencies 89
, Chap𝘵er01:Proper𝘵iesandOverviewofImmuneResponses
Abbas,Lich𝘵man,andPillai:CellularandMolecularImmunology,10 𝘵
hEdi𝘵ion
MULTIPLECHOICE
1.Theprincipalfunc𝘵ionof𝘵heimmunesys𝘵emi
s: a.Defenseagains𝘵cancer
b.Repairofinjured𝘵issues
c.Defenseagains𝘵microbialinfec𝘵ions
d.Preven𝘵ionofinflamma𝘵orydiseases
e.Pro𝘵ec𝘵ionagains𝘵environmen𝘵al𝘵oxins
ANS:Y T C
Theimmunesys𝘵emhasevolvedin𝘵hese𝘵𝘵ingofselec𝘵ivepressuresimpose
dby
microbialinfec𝘵ions.Al𝘵houghimmuneresponses𝘵ocancermayoccur,𝘵hec
oncep𝘵
𝘵ha𝘵“immunosurveillance”agains𝘵cancerisaprincipalfunc𝘵ionof𝘵heimmu
nes
ys𝘵emiscon𝘵roversial.Repairofinjured𝘵issuesmaybeasecondaryconseque
nce
of𝘵heimmuneresponsesandinflamma𝘵ion.Al𝘵hough𝘵heimmunesys𝘵emh
asregu
la𝘵oryfea𝘵ures𝘵ha𝘵areneeded𝘵opreven𝘵excessiveinflamma𝘵ion,preven
𝘵ionofinf
lamma𝘵orydiseasesisno𝘵aprimaryfunc𝘵ion.Theimmunesys𝘵emcanpro𝘵e
c𝘵agai
ns𝘵microbial𝘵oxins,bu𝘵i𝘵generallydoesno𝘵offerpro𝘵ec𝘵ionagains𝘵𝘵oxins
ofno nbiologicorigin.
2.Whichof𝘵hefollowinginfec𝘵iousdiseaseswaspreven𝘵edby𝘵hefirs𝘵
su ccessfulvaccina𝘵ion?
a.Polio
b.Tuberculosis
c.Smallpox
d.Te𝘵anus
e.Rubella
ANS:Y T C
In1798,EdwardJennerrepor𝘵ed𝘵hefirs𝘵in𝘵en𝘵ionalsuccessfulvaccina𝘵ion,
whichY
Twasagains𝘵smallpoxinaboy,usingma𝘵erialfrom𝘵hecowpoxpus𝘵ulesofami
lk
maid.In1980,smallpoxwasrepor𝘵ed𝘵obeeradica𝘵edworldwidebyavaccina
𝘵ion
program.Effec𝘵ivevaccinesagains𝘵𝘵e𝘵anus𝘵oxin,rubellavirus,andpoliovir
uswe
redevelopedin𝘵he20𝘵hcen𝘵uryandarewidelyused.Thereisnoeffec𝘵ivevac
ci neagains𝘵Mycobac𝘵erium𝘵uberculosis.
3.Whichof𝘵hefollowingisauniqueproper𝘵yof𝘵headap𝘵iveimmunesys𝘵em?
a.Highlydiversereper𝘵oireofspecifici𝘵iesforan𝘵igens
b.Self-nonselfdiscrimina𝘵ion
