NPLEX 1 LATEST 2026 EXAM QUESTIONS AND ANSWERS
GRADED A+
✔✔Factor V leidein does what? - ✔✔resistant to degradation by protein C - cause
hypercoaguability.
✔✔Reed sternberg cells associated with? - ✔✔Hodgkins
✔✔single nodes, good prognosis, associated with EBV, fever/nightsweats/weightloss -
✔✔Hodgkins
✔✔few symptoms, multiple nodes, b cell involvement - ✔✔Non-hodgkins
✔✔Bence jones proteins, rouleaux formations, m spike - ✔✔Multiple myeloma
✔✔T cell lukemia(s)? B cell lukemia(s)? - ✔✔T: ALL B: SLL, CLL, Hairy cell
✔✔Auer rods? - ✔✔AML
✔✔Philidelphia chromosome dz and translocation - ✔✔CML, 9;22
✔✔Polycythemia vera mutation? Effect? - ✔✔JAK2. Inc plasma, RBS mass and
episodic clots in vessel exremeties
✔✔Teardrop RBCs - ✔✔myelofibrosis
✔✔Function of chylomicrons - ✔✔dietary TGs to peripheral tissue, cholesterol to liver
✔✔Function of VLDL - ✔✔hepatic TGs to peripheral
✔✔function of IDL - ✔✔TGs and cholesterol to the liver
✔✔Activates NKs, T cells, Macrophages, released in response to viruses. -
✔✔Interferon, most commonly G (t cells)
✔✔inc vascular permeability (allows leukocytoes to pass), local inflammatory cytokine -
✔✔TNF (usually alpha)
✔✔DiGeorges syndrome - ✔✔thymic hypoplasia in third and fourth and pharyngeal
pouches
✔✔c. botulinum blocks what neurotransmitter? - ✔✔ACh
, ✔✔C. Tetani inbhitis what neurotransmitters? - ✔✔GABA and glycine
✔✔Names Herpes viruses 1-6 - ✔✔1 and 2 simplex, 3 zoster, 4 EBV, 5 CMV, 6 roseola
infantum
✔✔TORCH dzs - ✔✔Toxoplasmosis, (syphiliis, varciella, parvob-19) Rubela, CMV,
Herpes
✔✔MCC of diarreah in children - ✔✔adenovirus
✔✔Koplik spots and subactue sclerosing pan-encephalitis - ✔✔Rubeola (measles)
✔✔MCC of fatal respiratory inf in infants - ✔✔Respiratory syncytial virus
✔✔Only Hepatitis that is a DNA virus - ✔✔Hep B
✔✔bug in Hand foot and mouth dz, herpangina - ✔✔coxsackie B
✔✔what is the only virus that replicates in the cytoplasm? - ✔✔Poxvirus
✔✔Which virus is ssDNA? - ✔✔Parvo
✔✔What causes fifth dz aka. erythema infectiosum? - ✔✔Parvo B-19
✔✔which virus is dsRNA - ✔✔Rotavirus
✔✔sonic hedgehog gene devleops what? - ✔✔anterios-posterior axis patterning
✔✔Wnt-7 organizes what? - ✔✔dorsal-ventral axis
✔✔FGF (fibroblast growth factor) does what? - ✔✔stimulates mitosis of mesoderm,
lenghtns limbs
✔✔Hox gene organizes what? mutations does what? - ✔✔craniocaudal segmental
orginization. Mutations put appendages in wrong locations.
✔✔What layer of the placenta secretes hCG? - ✔✔syncytiotrophoblast
✔✔muscle used in inspiration? - ✔✔diaphragm and external intercostals
✔✔muscle that contracts in expiration? - ✔✔internal intercostals
✔✔most common defect causing hypercoaguability? - ✔✔Factor v leiden
GRADED A+
✔✔Factor V leidein does what? - ✔✔resistant to degradation by protein C - cause
hypercoaguability.
✔✔Reed sternberg cells associated with? - ✔✔Hodgkins
✔✔single nodes, good prognosis, associated with EBV, fever/nightsweats/weightloss -
✔✔Hodgkins
✔✔few symptoms, multiple nodes, b cell involvement - ✔✔Non-hodgkins
✔✔Bence jones proteins, rouleaux formations, m spike - ✔✔Multiple myeloma
✔✔T cell lukemia(s)? B cell lukemia(s)? - ✔✔T: ALL B: SLL, CLL, Hairy cell
✔✔Auer rods? - ✔✔AML
✔✔Philidelphia chromosome dz and translocation - ✔✔CML, 9;22
✔✔Polycythemia vera mutation? Effect? - ✔✔JAK2. Inc plasma, RBS mass and
episodic clots in vessel exremeties
✔✔Teardrop RBCs - ✔✔myelofibrosis
✔✔Function of chylomicrons - ✔✔dietary TGs to peripheral tissue, cholesterol to liver
✔✔Function of VLDL - ✔✔hepatic TGs to peripheral
✔✔function of IDL - ✔✔TGs and cholesterol to the liver
✔✔Activates NKs, T cells, Macrophages, released in response to viruses. -
✔✔Interferon, most commonly G (t cells)
✔✔inc vascular permeability (allows leukocytoes to pass), local inflammatory cytokine -
✔✔TNF (usually alpha)
✔✔DiGeorges syndrome - ✔✔thymic hypoplasia in third and fourth and pharyngeal
pouches
✔✔c. botulinum blocks what neurotransmitter? - ✔✔ACh
, ✔✔C. Tetani inbhitis what neurotransmitters? - ✔✔GABA and glycine
✔✔Names Herpes viruses 1-6 - ✔✔1 and 2 simplex, 3 zoster, 4 EBV, 5 CMV, 6 roseola
infantum
✔✔TORCH dzs - ✔✔Toxoplasmosis, (syphiliis, varciella, parvob-19) Rubela, CMV,
Herpes
✔✔MCC of diarreah in children - ✔✔adenovirus
✔✔Koplik spots and subactue sclerosing pan-encephalitis - ✔✔Rubeola (measles)
✔✔MCC of fatal respiratory inf in infants - ✔✔Respiratory syncytial virus
✔✔Only Hepatitis that is a DNA virus - ✔✔Hep B
✔✔bug in Hand foot and mouth dz, herpangina - ✔✔coxsackie B
✔✔what is the only virus that replicates in the cytoplasm? - ✔✔Poxvirus
✔✔Which virus is ssDNA? - ✔✔Parvo
✔✔What causes fifth dz aka. erythema infectiosum? - ✔✔Parvo B-19
✔✔which virus is dsRNA - ✔✔Rotavirus
✔✔sonic hedgehog gene devleops what? - ✔✔anterios-posterior axis patterning
✔✔Wnt-7 organizes what? - ✔✔dorsal-ventral axis
✔✔FGF (fibroblast growth factor) does what? - ✔✔stimulates mitosis of mesoderm,
lenghtns limbs
✔✔Hox gene organizes what? mutations does what? - ✔✔craniocaudal segmental
orginization. Mutations put appendages in wrong locations.
✔✔What layer of the placenta secretes hCG? - ✔✔syncytiotrophoblast
✔✔muscle used in inspiration? - ✔✔diaphragm and external intercostals
✔✔muscle that contracts in expiration? - ✔✔internal intercostals
✔✔most common defect causing hypercoaguability? - ✔✔Factor v leiden
