NAGELHOUT PHARMACOLOGY 1 EXAM 1
TEST BANK FULL QUESTIONS AND
SOLUTIONS VERIFIED PASS GUARANTEED
SUCCESS
●● pharmacodynamics
Answer: relationship between drug concentration over time and
therapeutic response
●● chemical specificity for receptors
Answer: specificity between receptors and bonds, EX strict structural
requirements for binding
●● receptor saturability
Answer: only a finite number of receptors that can be occupied
●● receptor affinity
Answer: measure of attraction between drug and receptor
●● drug potency
Answer: dose required to have certain effect, related to affinity of
receptor
,●● ED50
Answer: dose which produces 50% of maximum effect, used to compare
drugs in terms of potency
●● drug efficacy
Answer: maximal effect achievable for a drug, related to number of
receptor/complexes formed, intrinsic activity of drug in activating
receptor
●● full agonist
Answer: affinity to, and full activator, of receptor (high intrinsic
activity/efficacy), increases activity above basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
●● inverse agonist
Answer: affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full agonist
(metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
●● partial agonist
, Answer: affinity to receptor but only partially activates a receptor,
produces less than the ceiling effect of a full agonist
●● pure antagonist
Answer: affinity to receptor but produces no activation, dose curve is a
straight line across the bottom of an XY graph (EX oraverse vasodilates,
overcoming the vasocontriction of the LA)
●● neutral antgonist
Answer: has no activity in the absence of an agonist or inverse agonist
but can block either's activity
●● competitive antagonist
Answer: lacks efficacy, competes with agonists for binding sites,
inhibitory effect can be overcome by increasing concentration of
competing agonist
●● every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is different
for every patient
Answer:
●● know the second slide on page 10 of principles of drugs
TEST BANK FULL QUESTIONS AND
SOLUTIONS VERIFIED PASS GUARANTEED
SUCCESS
●● pharmacodynamics
Answer: relationship between drug concentration over time and
therapeutic response
●● chemical specificity for receptors
Answer: specificity between receptors and bonds, EX strict structural
requirements for binding
●● receptor saturability
Answer: only a finite number of receptors that can be occupied
●● receptor affinity
Answer: measure of attraction between drug and receptor
●● drug potency
Answer: dose required to have certain effect, related to affinity of
receptor
,●● ED50
Answer: dose which produces 50% of maximum effect, used to compare
drugs in terms of potency
●● drug efficacy
Answer: maximal effect achievable for a drug, related to number of
receptor/complexes formed, intrinsic activity of drug in activating
receptor
●● full agonist
Answer: affinity to, and full activator, of receptor (high intrinsic
activity/efficacy), increases activity above basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
●● inverse agonist
Answer: affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full agonist
(metoprolol), decreases activity below basal level of receptor where
receptor has a constitutive (intrinsic basal) level of activity in the
absence of a ligand
●● partial agonist
, Answer: affinity to receptor but only partially activates a receptor,
produces less than the ceiling effect of a full agonist
●● pure antagonist
Answer: affinity to receptor but produces no activation, dose curve is a
straight line across the bottom of an XY graph (EX oraverse vasodilates,
overcoming the vasocontriction of the LA)
●● neutral antgonist
Answer: has no activity in the absence of an agonist or inverse agonist
but can block either's activity
●● competitive antagonist
Answer: lacks efficacy, competes with agonists for binding sites,
inhibitory effect can be overcome by increasing concentration of
competing agonist
●● every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is different
for every patient
Answer:
●● know the second slide on page 10 of principles of drugs
