Molecular Cell Biology
Harvey Lodish, Arnold Berk et al.
9th Edition
,Table of Contents
Chapter 02: Chemical Foundations True / False 1
Chapter 03: Protein Structure and Function Multiple Choice 12
Chapter 04: Culturing and Visualizing Cells Multiple Choice 25
Chapter 05: Fundamental Molecular Genetic Mechanisms Multiple Choice 34
Chapter 06: Molecular Genetic Techniques Multiple Choice 47
Chapter 07: Genes, Chromatin, and Chromosomes Multiple Choice 61
Chapter 08: Transcriptional Control of Gene Expression Multiple Choice 73
Chapter 09: Post-Transcriptional Gene Control Multiple Choice 86
Chapter 10: Biomembrane Structure Multiple Choice 99
Chapter 11: Transmembrane Transport of Ions and Small Molecules Multiple Choice 109
Chapter 12: Cellular Energetics Multiple Choice 120
Chapter 13: Moving Proteins into Membranes and Organelles Multiple Choice 133
Chapter 14: Vesicular Traffic, Secretion, and Endocytosis Multiple Choice 142
Chapter 15: Receptors, Hormones, and Cell Signaling Multiple Choice 152
Chapter 16: Growth Factor and Cytokine Signaling Pathways That Control Gene
Expression Multiple Choice 163
Chapter 17: Cell Organization and Movement I: Microfilaments Multiple Choice 175
Chapter 18: Cell Organization and Movement II: Microtubules and Intermediate Filaments
Multiple Choice 187
Chapter 19: The Eukaryotic Cell Cycle Multiple Choice 197
Chapter 20: Integrating Cells into Tissues Multiple Choice 208
Chapter 21: Responding to the Cellular Environment Multiple Choice 219
Chapter 22: Stem Cells, Cell Asymmetry, and Regulated Cell Death Multiple Choice 229
Chapter 23: Cells of the Nervous System Multiple Choice 240
Chapter 24: Immunology Multiple Choice 251
Chapter 25: Cancer Multiple Choice 262
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
Chapter 02: Chemical Foundations
True / False
1. The amount of free energy released when bonds are broken during a reaction is higher when the molecule has more
electronegative atoms.
a. True
b. False
ANSWER: False
DIFFICULTY: Moderate
REFERENCES: Section: Biochemical Energetics
KEYWORDS: Bloom's: Applying
Multiple Choice
2. Covalent bonds between which of the following pairs of atoms are nonpolar?
a. C–C
b. C–H
c. O–H
d. A and B
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Covalent Bonds and Noncovalent Interactions
Chapter 2
KEYWORDS: Bloom's: Remembering
3. Which of the following is a noncovalent interaction?
a. hydrophobic effect
b. ionic interactions
c. van der Waals interactions
d. all of the above
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Covalent Bonds and Noncovalent Interactions
Chapter 2
KEYWORDS: Bloom's: Remembering
4. Which of the following is the strongest interaction?
a. hydrogen bond
b. ionic bond
c. phosphoanhydride bond
d. van der Waals interaction
ANSWER: c
DIFFICULTY: easy
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
REFERENCES: Section: Covalent Bonds and Noncovalent Interactions
Chapter 2
KEYWORDS: Bloom's: Understanding
5. Which of the following is the weakest interaction?
a. hydrogen bond
b. ionic bond
c. phosphoanhydride bond
d. van der Waals interaction
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Covalent Bonds and Noncovalent Interactions
Chapter 2
KEYWORDS: Bloom's: Understanding
6. When two atoms differing in electronegativity are joined in a covalent bond, then the:
a. electrons are shared equally between the atoms.
b. bond is nonpolar.
c. resulting compound is devoid of any dipole moment.
d. atom with the greater electronegativity attracts the bonded electrons more strongly.
ANSWER: d
DIFFICULTY: moderate
REFERENCES: Section: Covalent Bonds and Noncovalent Interactions
Chapter 2
KEYWORDS: Bloom's: Understanding
7. Which of the following is a negatively charged amino acid?
a. alanine
b. aspartate
c. glutamine
d. histidine
ANSWER: b
DIFFICULTY: easy
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
8. Which of the following is/are a hydrophilic amino acid?
a. alanine
b. leucine
c. tryptophan
d. serine
ANSWER: d
DIFFICULTY: easy
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
9. Adenosine is a:
a. component of RN
b. nucleoside.
c. pyrimidine.
d. a and b
ANSWER: d
DIFFICULTY: moderate
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
10. Based on what you know about hydrophobic interactions, which of the following is/are composed of a bilayer?
a. a cell’s membrane
b. spontaneously aggregated phospholipids surrounding an aqueous interior
c. lipid vesicles that have budded off the cell’s membrane
d. all of the above
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
11. A nucleotide can vary in _____.
a. the base
b. the sugar
c. the phosphate group
d. the sugar and the base
ANSWER: d
DIFFICULTY: moderate
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Understanding
12. Which of the following is NOT one of the ways RNA differs from DNA?
a. Ribonucleotides have a hydroxyl group on the 2 carbon of their sugar subunit.
b. Ribonucleotides can have enzymatic activity.
c. Ribonucleotides contain a phosphate group.
d. Ribonucleotides can contain the base uracil.
ANSWER: c
DIFFICULTY: moderate
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
13. How do phospholipids interact with water molecules?
a. The polar heads interact with water; the nonpolar tails do not.
b. Phospholipids don't interact with water because water is polar and lipids are nonpolar.
c. The polar heads avoid water; the nonpolar tails attract water (because water is polar and opposites attract).
d. Phospholipids dissolve in water.
ANSWER: a
DIFFICULTY: easy
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Remembering
14. Which of the following is the BEST explanation for why vegetable oil is a liquid at room temperature while animal fats are
solid?
a. Vegetable oil has fewer double bonds than animal fats.
b. Animal fats have no amphipathic character.
c. Vegetable oil has longer fatty-acid tails than do animal fats.
d. Vegetable oil has more double bonds than do animal fats.
ANSWER: a
DIFFICULTY: easy
REFERENCES: Section: Chemical Building Blocks of Cells
Chapter 2
KEYWORDS: Bloom's: Understanding
15. A 1-mL solution of 0.05 M H2SO4 is diluted to 100 mL at 25°C. What is the pH of the resulting solution?
a. 1
b. 2
c. 3
d. 4
ANSWER: c
DIFFICULTY: moderate
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Applying
16. An Archaea cell living in an abandoned mine is found to contain a very high concentration of protons. It is likely that this cell:
a. has a high ph and is acidic
b. has a high ph and is alkaline.
c. has low ph and is acidic
d. has a low pH and is alkaline.
ANSWER: c
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
DIFFICULTY: easy
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Understanding
17. A 1-mL solution of 0.1 M NaOH is diluted to 1 L at 25°C. What is the pH of the resulting solution?
a. 1
b. 7
c. 10
d. 13
ANSWER: c
DIFFICULTY: moderate
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Applying
18. The pKa of the weak base NH3 is 9.25. When present in lysosomes, a subcellular organelle—ammonia—is almost totally
protonateD) Which of the pH values listed below is most likely to be that of the lysosome lumen?
a. 1
b. 5
c. 8
d. 14
ANSWER: b
DIFFICULTY: difficult
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Understanding
19. If the equilibrium constant for the reaction A→B is 0.5 and the initial concentration of A is 25 mM and of B is 12.5 mM, then
the reaction:
a. will proceed in the direction it is written, producing a net increase in the concentration of B.
b. will produce energy, which can be used to drive ATP synthesis.
c. will proceed in the reverse direction, producing a net increase in the concentration of A.
d. is at equilibrium.
ANSWER: d
DIFFICULTY: difficult
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Applying
20. For the binding reaction A + B ➝ AB, the dissociation constant is equal to:
a. [AB]/([A]+[B])
b. ([A] + [B])/[AB].
c. Keq
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
d. The first and third answers are correct.
ANSWER: b
DIFFICULTY: easy
REFERENCES: Section: Chemical Reactions and Chemical Equilibrium
Chapter 2
KEYWORDS: Bloom's: Applying
21. In a biochemical reaction in which ΔH < 0 and ΔS > 0:
a. the reaction is spontaneous.
b. the reaction is endothermic
c. the reaction is endergonic
d. ΔG is positive.
ANSWER: a
DIFFICULTY: easy
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Understanding
22. In the reaction NAD+ + H+ + 2e−→ NADH, NAD+ becomes:
a. dehydrated
b. hydrolyzed
c. oxidized
d. reduced
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Understanding
23. The ultimate source of energy used to make ATP for all cells is:
a. electricity.
b. heat.
c. light.
d. magnetism.
ANSWER: c
DIFFICULTY: moderate
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Remembering
24. Hydrolysis of ATP:
a. is endothermic
b. has a positive ΔG value.
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
c. must be coupled to an energetically favorable reaction.
d. none of the above
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Understanding
25. What is [P]/[R] when ΔG =ΔG°´?
a. –1
b. 0
c. 1
d. 2.3
ANSWER: b
DIFFICULTY: moderate
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Applying
26. A reaction with a positive ΔG value can be made energetically favorable by increasing the:
a. ΔG°'.
b. starting concentration of products.
c. starting concentration of reactants.
d. The first two answers are correct.
ANSWER: c
DIFFICULTY: moderate
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Understanding
27. Photosynthesis by plants and certain microbes traps the energy in light and uses it to:
a. Reduce glucose into carbon dioxide.
b. synthesize ATP from ADP and inorganic phosphate.
c. generate ATP from the oxidation of reduced inorganic compounds.
d. none of the above
ANSWER: b
DIFFICULTY: moderate
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Remembering
28. NAD+ and FAD are often referred to as:
a. redox proteins.
b. polymers.
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Test Bank - Molecular Cell Biology, 9th Edition (Lodish, 2021)
c. reduced dinucleotides.
d. electron-carrying coenzymes.
ANSWER: d
DIFFICULTY: easy
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Remembering
29. Which of the following is true about an observed change in free energy (ΔG)?
a. Free energy was created when the Big Bang occurred
b. It can be calculated from the total change in energy, temperature, and change in entropy.
c. If a reaction's free energy is greater than zero, it is likely to happen spontaneously.
d. Free energy is comparable to unusable energy.
ANSWER: b
DIFFICULTY: easy
REFERENCES: Section: Biochemical Energetics
Chapter 2
KEYWORDS: Bloom's: Understanding
30. Which of the following is a monosaccharide?
a. fructose
b. galactose
c. glucose
d. all of the above
ANSWER: d
DIFFICULTY: Easy
REFERENCES: Section: Chemical Building Blocks of Cells
KEYWORDS: Bloom's: Remembering
31. What is the major structural difference between starch and cellulose?
a. the types of monosaccharide subunits in the molecules
b. the amount of branching that occurs in the molecule
c. that humans can only ingest starch
d. the type of glycosidic linkages in the molecule
ANSWER: d
DIFFICULTY: Moderate
REFERENCES: Section: Chemical Building Blocks of Cells
KEYWORDS: Bloom's: Understanding
Essay
32. The interactions between two proteins such as an antibody and an antigen or a hormone and its receptor are quite strong
despite the fact that these interactions consist of relatively weak noncovalent bonds. How can this be?
ANSWER: Two proteins can bind tightly because of molecular complementarity, in which multiple noncovalent
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