Week 1 2026 | Questions,
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Updated 2026 Questions and Answers
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, Factors that affect drug absorption (5) Rate of dissolution
Surface area
Blood flow
Lipid solubility
PH partitioning
Factors that affect drug distribution (4) Blood flow to tissues
Ability to exit vascular system
Blood-brain barrier
Protein-binding capacity
Pharmacodynamics The study of biochemical and physiologic effects of drugs on the body and the
molecular mechanisms by which those effects are produced
"What the body does to the drug"
Phamacodynamics: 3 mechanisms of action Receptor
Enzyme
Non-selective interactions (i.e. chemo)
Types of drug therapy (7) Acute
Maintenance (HTN/bc)
Supplemental (insulin)
Palliative
Supportive (IV fluid)
Prophylactic
Empirical (broad-spectrum abx)
Idiosyncratic Effect Unexpected response to medication
Tolerance Declining response to a drug
Dependence Physiological/psychological need for a drug; needs drug for normal function
Addiction Compulsive use of a drug despite negative/dangerous effects
Drug interactions: drug-drug When 2 drugs compete for metabolizing enzymes
Drug interactions: food-drug Grapefruit juice or leafy greens
Drug interactions: additive 1+1 = 2; both provide intended effect
Drug interactions: antagonistic 1+1 = <2; less than desired effect of one or both drugs
Drug interactions: synergistic 1+1 = >2; sum total effect is greater than if given alone (i.e. lisinopril + HCTZ)
Drug interactions: incompatibility 1+1 does not equal 2; two IV drugs given together causing decomposition of one
or both drugs