Hematology II Final Exam
Morphology 2026 |
Questions, Notes & Study
Guide
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success|
Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales
Included
,Chronic eosinophilic leukemia peripheral blood WBC >30,000: increased eosinophils with immatures;
-LAP normal
-BM <5% blasts
-prognosis is poor, die within 1 year
Polycythemia rubra vera in bone marrow
Polycythemia vera in peripheral blood
Polycythemia vera in bone marrow
Essential thrombocythemia in peripheral blood myeloproliferative disorder characterized by increase in abnormal platelets
Essential thrombocythemia in peripheral blood with -sustained markedly elevated platelet count
platelet clumping -thrombocytosis in XS of million/uL
-specimens need to be diluted
-morphology: giant platelets with dysplastic features, micromegakaryocytes, &
bald megakaryocyte nuclei
-mild leukocytosis with eosinophilia and basophilia
Essential thrombocythemia in peripheral blood with large
forms of platelets
,Normal megakaryocyte -megakaryocyte undergo endomitosis
-thus MKs become polyploid during amplification
-most platelet forming MKs have a ploidy of 16N, (4N-64N)
-the largest normally occurring cells in the marrow
EDTA in vitro induced change (platelet satelitism)
Dry tap from bone marrow are not infrequent in essential thrombocythemia, as the blood may clot very
quickly, resulting in poor smear--this slide shows numerous platelets
Megakaryoblasts/micromegakaryocytes in a dilute note dense chromatin, binucleation and vacuolated cytoplasm with budding
marrow
Dysplastic megakaryocytes in bone marrow hyperlobated nuclei (center);
-micromegakaryocytes with dense nuclear chromatin (left)
-immature megakaryocytes with nuclear lobe separation
Primary Myelofibrosis in bone marrow panmyelosiss of BM; varying degree of hypercellulairty of all cellular elements
-progressive collagen fibrosis of BM
-fibrosis is a secondary, reactive process thought to be mediated by cytokines
produced by cells of the abnormal clone
-fibroblasts are normal & function like normal bone marrow fibroblasts
Leukoerythroblastosis in primary myelofibrosis with rare blasts, nucleated red blood cells, large platelets, and teardrop shaped
red cells (dacrocytes)
, Fibrous connective tissue replacing hematopoietic
connective tissue in bone marrow specimen in primary
myelofibrosis
Primary myelofibrosis: abnormal RBCs, basophil, &
relatively normal neutrophil
Primary myelofibrosis with abnormal giant platelet
Primary myelofibrosis with nRBC, giant platelet, and
myeloblasts
Primary myelofibrosis with a fragment of megakaryocyte looks like a lymphocyte
Chronic neutrophilic leukemia in peripheral blood neutrophils not dysplastic--may have toxic granulation;
-RBC and PLT have normal morphology
Chronic neutrophilic leukemia in bone marrow
chronic eosinophilic leukemia in peripheral blood clonal proliferation of eos
-eos found in other tissues
-organ dysfunction due to eos degranulation and damaging surrounding tissue
Morphology 2026 |
Questions, Notes & Study
Guide
| Graded A+ | Guaranteed
success|
Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales
Included
,Chronic eosinophilic leukemia peripheral blood WBC >30,000: increased eosinophils with immatures;
-LAP normal
-BM <5% blasts
-prognosis is poor, die within 1 year
Polycythemia rubra vera in bone marrow
Polycythemia vera in peripheral blood
Polycythemia vera in bone marrow
Essential thrombocythemia in peripheral blood myeloproliferative disorder characterized by increase in abnormal platelets
Essential thrombocythemia in peripheral blood with -sustained markedly elevated platelet count
platelet clumping -thrombocytosis in XS of million/uL
-specimens need to be diluted
-morphology: giant platelets with dysplastic features, micromegakaryocytes, &
bald megakaryocyte nuclei
-mild leukocytosis with eosinophilia and basophilia
Essential thrombocythemia in peripheral blood with large
forms of platelets
,Normal megakaryocyte -megakaryocyte undergo endomitosis
-thus MKs become polyploid during amplification
-most platelet forming MKs have a ploidy of 16N, (4N-64N)
-the largest normally occurring cells in the marrow
EDTA in vitro induced change (platelet satelitism)
Dry tap from bone marrow are not infrequent in essential thrombocythemia, as the blood may clot very
quickly, resulting in poor smear--this slide shows numerous platelets
Megakaryoblasts/micromegakaryocytes in a dilute note dense chromatin, binucleation and vacuolated cytoplasm with budding
marrow
Dysplastic megakaryocytes in bone marrow hyperlobated nuclei (center);
-micromegakaryocytes with dense nuclear chromatin (left)
-immature megakaryocytes with nuclear lobe separation
Primary Myelofibrosis in bone marrow panmyelosiss of BM; varying degree of hypercellulairty of all cellular elements
-progressive collagen fibrosis of BM
-fibrosis is a secondary, reactive process thought to be mediated by cytokines
produced by cells of the abnormal clone
-fibroblasts are normal & function like normal bone marrow fibroblasts
Leukoerythroblastosis in primary myelofibrosis with rare blasts, nucleated red blood cells, large platelets, and teardrop shaped
red cells (dacrocytes)
, Fibrous connective tissue replacing hematopoietic
connective tissue in bone marrow specimen in primary
myelofibrosis
Primary myelofibrosis: abnormal RBCs, basophil, &
relatively normal neutrophil
Primary myelofibrosis with abnormal giant platelet
Primary myelofibrosis with nRBC, giant platelet, and
myeloblasts
Primary myelofibrosis with a fragment of megakaryocyte looks like a lymphocyte
Chronic neutrophilic leukemia in peripheral blood neutrophils not dysplastic--may have toxic granulation;
-RBC and PLT have normal morphology
Chronic neutrophilic leukemia in bone marrow
chronic eosinophilic leukemia in peripheral blood clonal proliferation of eos
-eos found in other tissues
-organ dysfunction due to eos degranulation and damaging surrounding tissue
