MICB 4131 EXAM 4 QUESTIONS AND VERIFIED
ANSWERS
1. Innate immunity is specific for individual pathogens, and is able to discriminate
between closely related molecular structures. - Answers - False
2. Adaptive immunity recognizes a broad class of pathogens. - Answers - False
3. Toll-like receptors: - Answers - A. Induce the secretion of cytokines, chemokines, and
anti-microbial proteins/molecules B. Found on intracellular membranes in organelles
and on the cell surface membrane E. A and B
4. TNFalpha causes vascular permeability and fever: - Answers - True
5. Antibodies are secreted by B cells (plasma cells): - Answers - True
6. Neutrophils fight infections by: - Answers - A. Phagocytosis B. Release of reactive
oxygen C. NETs D. All of these
7. NK cells are a part of the innate immune system and function in killing other cells
through cytokine secretion: - Answers - True
8. RIG-I binding to viral RNA leads production of: - Answers - A. interferon
9. PAMPs are: - Answers - C. Repetitive arrays of proteins, carbohydrates, or lipids on
pathogens that are recognized by pattern recognition receptors (PRRs)
10. IL-2 is a: - Answers - B. Cytokine
11. Leukocyte rolling is mediated by_____ on endothelium: - Answers - C. Selectins
12. TLR5 recognizes _____ on/in the______ : - Answers - B. Flagella, cell surface
1. The first antibody isotype secreted after B cells are stimulated are: - Answers - A. IgM
2. The final maturational events of a B cell occur in the primary follicles after interacting
with follicular dendritic cells (FDC) - Answers - A. True
3. Chemokines signal through: - Answers - C. G protein coupled receptors
4. V(D)J recombination occurs in: - Answers - D. Bone marrow
, 5. This protein negatively regulates cytokine signaling through the JaK/STAT pathway
(hint: negative feedback loop): - Answers - C. SOCS
6. IL-7 is needed for B cell development from a Pre-B cell to an Immature B cell. -
Answers - A. True
7. The following gene determines if a cell will become a B cell: - Answers - C. Pax5
8. This enzyme is involved in isotype switching by inducing nicks in DNA - Answers - A.
AID
9. IgM is an antibody isotype in breast milk that is transferred to newborns in a process
known as passive immunity. - Answers - B. False
10. Through selection, somatic hypermutation results in surviving B cells with: -
Answers - B. Increased antigen binding
11. The following molecules are important for cytokine signaling after a cytokine
engages its receptor: - Answers - C. Jaks and STATS
12. Germinal centers in the lymph node are where somatic hypermutation occurs. -
Answers - A. True
1. Resident memory T cells are T cells that do not re-circulate throughout the whole
body and stay in one organ. - Answers - a. True
2. Cancer cells can be eliminated by NK cells. - Answers - a. True
3. Autoimmune responses can be suppressed by which cells: - Answers - c. T
regulatory cells (Tregs)
4. ADCC is dependent on: - Answers - d. Antibody
5. T cells that are chronically (i.e constantly) stimulated by antigen can become
dysfunctional or exhausted. - Answers - a. True
6. Th1 CD4 T cells secrete IL-4 - Answers - b. False
7. Which of the following is a transcription factor that drives differentiation of Th17 cells?
- Answers - a. ROR-gT
8. ADCC is mediated by neutrophils, NK cells, eosinophils, and macrophages. -
Answers - a. True
9. NK cells can form memory against antigens. - Answers - b. False
ANSWERS
1. Innate immunity is specific for individual pathogens, and is able to discriminate
between closely related molecular structures. - Answers - False
2. Adaptive immunity recognizes a broad class of pathogens. - Answers - False
3. Toll-like receptors: - Answers - A. Induce the secretion of cytokines, chemokines, and
anti-microbial proteins/molecules B. Found on intracellular membranes in organelles
and on the cell surface membrane E. A and B
4. TNFalpha causes vascular permeability and fever: - Answers - True
5. Antibodies are secreted by B cells (plasma cells): - Answers - True
6. Neutrophils fight infections by: - Answers - A. Phagocytosis B. Release of reactive
oxygen C. NETs D. All of these
7. NK cells are a part of the innate immune system and function in killing other cells
through cytokine secretion: - Answers - True
8. RIG-I binding to viral RNA leads production of: - Answers - A. interferon
9. PAMPs are: - Answers - C. Repetitive arrays of proteins, carbohydrates, or lipids on
pathogens that are recognized by pattern recognition receptors (PRRs)
10. IL-2 is a: - Answers - B. Cytokine
11. Leukocyte rolling is mediated by_____ on endothelium: - Answers - C. Selectins
12. TLR5 recognizes _____ on/in the______ : - Answers - B. Flagella, cell surface
1. The first antibody isotype secreted after B cells are stimulated are: - Answers - A. IgM
2. The final maturational events of a B cell occur in the primary follicles after interacting
with follicular dendritic cells (FDC) - Answers - A. True
3. Chemokines signal through: - Answers - C. G protein coupled receptors
4. V(D)J recombination occurs in: - Answers - D. Bone marrow
, 5. This protein negatively regulates cytokine signaling through the JaK/STAT pathway
(hint: negative feedback loop): - Answers - C. SOCS
6. IL-7 is needed for B cell development from a Pre-B cell to an Immature B cell. -
Answers - A. True
7. The following gene determines if a cell will become a B cell: - Answers - C. Pax5
8. This enzyme is involved in isotype switching by inducing nicks in DNA - Answers - A.
AID
9. IgM is an antibody isotype in breast milk that is transferred to newborns in a process
known as passive immunity. - Answers - B. False
10. Through selection, somatic hypermutation results in surviving B cells with: -
Answers - B. Increased antigen binding
11. The following molecules are important for cytokine signaling after a cytokine
engages its receptor: - Answers - C. Jaks and STATS
12. Germinal centers in the lymph node are where somatic hypermutation occurs. -
Answers - A. True
1. Resident memory T cells are T cells that do not re-circulate throughout the whole
body and stay in one organ. - Answers - a. True
2. Cancer cells can be eliminated by NK cells. - Answers - a. True
3. Autoimmune responses can be suppressed by which cells: - Answers - c. T
regulatory cells (Tregs)
4. ADCC is dependent on: - Answers - d. Antibody
5. T cells that are chronically (i.e constantly) stimulated by antigen can become
dysfunctional or exhausted. - Answers - a. True
6. Th1 CD4 T cells secrete IL-4 - Answers - b. False
7. Which of the following is a transcription factor that drives differentiation of Th17 cells?
- Answers - a. ROR-gT
8. ADCC is mediated by neutrophils, NK cells, eosinophils, and macrophages. -
Answers - a. True
9. NK cells can form memory against antigens. - Answers - b. False
