ASCP CG CERTIFICATION SCRIPT 2026
COMPLETE QUESTIONS AND CORRECT
ANSWERS
◉Unstained chromosome preparation should be viewed using
which scope? Answer: Phase contrast condenser
◉The minimum band level necessary to detect prader-willi
syndrome is? Answer: 550 at the lowest
15q11.2 is visible at that level
See CAP regulation CYG.42300
◉A regulatory inspecter requests a copy of a lab patient's record for
his inspection files, the tech should: Answer: Deny the inspector a
copy of the record
See HIPAA compliance policy
◉According to CAP regulations, what is the minimum band level for
consitutional specimens? Answer: 400
,The suggested level for most constitutional specimen is 550, but 400
is the lowest acceptible level
See CAP regulation CYG.42200
◉Placental tissue is submitted for chromosome analysis, to optimize
the liklihood of obtaining fetal cells, where should the tech select
tissue from? Answer: The fetal side of the spcimen (when possible to
be identified from the decidua)
◉In a compound light microscope, the aperature stop affects
resolution and contrast by: Answer: Changing the angle of the cone
of light inside the objective
◉What is the correct nomenclature to describe a hematologic
disorder with trisomy 21 in 6 cells and 14 cells that are normal?
Answer: 47,XY,+21?c[6]/46,XY[14]
?c -- indicates questioning whether the trisomy is constitutional or
not as it was seen in only 6 cells
◉The G-light bands produced by routine GTG banding represent:
Answer: The active regions of the chromosome
aka euchromatin -- gene-rich and GC rich DNA, early replicating
, ◉Which of the following is not assocated with a microdeletion?
1. Prader-Willi
2. DiGeorge
3. Rubinstein-Taybi
4. Langer-Giedion Answer: 3. Rubinstein-Taybi
Associated with an autosomal dominant mutation in the CREB or
CREBBP gene(s)
Rarely assocated with a deletion in 16p13.3 (12% of cases, not the
predominant cause, detected by FISH)
Presents as facial dysmorphism, broad thumbs, broad big toes, and
growth and mental retardation
◉The dark bands produced by routune GTG banding represent:
Answer: AT-rich regions of the chromosome
aka heterpchromatin, and gene-poor chromatin, late replicating DNA
COMPLETE QUESTIONS AND CORRECT
ANSWERS
◉Unstained chromosome preparation should be viewed using
which scope? Answer: Phase contrast condenser
◉The minimum band level necessary to detect prader-willi
syndrome is? Answer: 550 at the lowest
15q11.2 is visible at that level
See CAP regulation CYG.42300
◉A regulatory inspecter requests a copy of a lab patient's record for
his inspection files, the tech should: Answer: Deny the inspector a
copy of the record
See HIPAA compliance policy
◉According to CAP regulations, what is the minimum band level for
consitutional specimens? Answer: 400
,The suggested level for most constitutional specimen is 550, but 400
is the lowest acceptible level
See CAP regulation CYG.42200
◉Placental tissue is submitted for chromosome analysis, to optimize
the liklihood of obtaining fetal cells, where should the tech select
tissue from? Answer: The fetal side of the spcimen (when possible to
be identified from the decidua)
◉In a compound light microscope, the aperature stop affects
resolution and contrast by: Answer: Changing the angle of the cone
of light inside the objective
◉What is the correct nomenclature to describe a hematologic
disorder with trisomy 21 in 6 cells and 14 cells that are normal?
Answer: 47,XY,+21?c[6]/46,XY[14]
?c -- indicates questioning whether the trisomy is constitutional or
not as it was seen in only 6 cells
◉The G-light bands produced by routine GTG banding represent:
Answer: The active regions of the chromosome
aka euchromatin -- gene-rich and GC rich DNA, early replicating
, ◉Which of the following is not assocated with a microdeletion?
1. Prader-Willi
2. DiGeorge
3. Rubinstein-Taybi
4. Langer-Giedion Answer: 3. Rubinstein-Taybi
Associated with an autosomal dominant mutation in the CREB or
CREBBP gene(s)
Rarely assocated with a deletion in 16p13.3 (12% of cases, not the
predominant cause, detected by FISH)
Presents as facial dysmorphism, broad thumbs, broad big toes, and
growth and mental retardation
◉The dark bands produced by routune GTG banding represent:
Answer: AT-rich regions of the chromosome
aka heterpchromatin, and gene-poor chromatin, late replicating DNA
