ATI PSYCHOPHARMACOLOGY
QUESTIONS AND ANSWERS
LATEST UPDATE EXAM
What is the MOA of antipsychotics? - answer- Dopamine receptor antagonists
What are the two classes of antipsychotics? - answer- Typicals - antagonize D2 only,
greater risk of side effects
Atypicals - antagonize D2, D4, and 5HTZ, favorable for long term treatment
*Risperidone [Risperdal] - atypical, only acts on D2 and 5HTz
Typical Antipsychotic Rx - answer- Haloperidol [Haldol], Chlorpromazine [Thorazine],
Prochlorperazine [Compazine], Fluphenazine [Prolixin]
Atypical Antipsychotic Rx - answer- Risperidone [Risperdal]
Olanzapine [Zyprexa]
Quetiapine [Seroquel]
Clozapine [Clozaril]
Ziprasidone [Geodon]
Aripiprazole [Abilify]
What are the indications for antipsychotic therapy? - answer- 1. Psychotic disorders
, 2. Acute agitation - haloperidol, ziprasidone
3. Mood disorders - MDD, BP2 - adjunct to SSRI, esp. Aripiprazole
4. Movement d/o involving excessive dopaminergic stimulation (i.e. Huntington's, Tourette's)
Which antipsychotic is associated with agranulocytosis? - answer- Clozapine [Clozaril]
Which antipsychotic is associated with prolongation of QT interval? - answer- Ziprasidone
[Geodon]
Which antipsychotic is the least sedating? - answer- Risperidone [Risperdal]
What are the AE associated with dopaminergic blockade in patients on antipsychotics? - answer-
1. Extrapyramidal sx - TD, NMS, akathisia (typicals!)
2. Galactorrhea, gynecomastia, amenorrhea 2' to elevated prolactin
A nurse is educating a group of high school students about mental illness. Which of the
following statements should the nurse make about etiology of a mental illness?
a. "Schizophrenia can be detected through a complete blood count."
b. "It is possible to predict the likelihood of developing manifestations of a mental illness."
c. "Developing a mental illness seems to be related to both genetic and environmental factors."
d. "Regular physical examinations are commonly used to diagnose mental illness." - answer-
c. "Developing a mental illness seems to be related to both genetic and environmental
factors."
QUESTIONS AND ANSWERS
LATEST UPDATE EXAM
What is the MOA of antipsychotics? - answer- Dopamine receptor antagonists
What are the two classes of antipsychotics? - answer- Typicals - antagonize D2 only,
greater risk of side effects
Atypicals - antagonize D2, D4, and 5HTZ, favorable for long term treatment
*Risperidone [Risperdal] - atypical, only acts on D2 and 5HTz
Typical Antipsychotic Rx - answer- Haloperidol [Haldol], Chlorpromazine [Thorazine],
Prochlorperazine [Compazine], Fluphenazine [Prolixin]
Atypical Antipsychotic Rx - answer- Risperidone [Risperdal]
Olanzapine [Zyprexa]
Quetiapine [Seroquel]
Clozapine [Clozaril]
Ziprasidone [Geodon]
Aripiprazole [Abilify]
What are the indications for antipsychotic therapy? - answer- 1. Psychotic disorders
, 2. Acute agitation - haloperidol, ziprasidone
3. Mood disorders - MDD, BP2 - adjunct to SSRI, esp. Aripiprazole
4. Movement d/o involving excessive dopaminergic stimulation (i.e. Huntington's, Tourette's)
Which antipsychotic is associated with agranulocytosis? - answer- Clozapine [Clozaril]
Which antipsychotic is associated with prolongation of QT interval? - answer- Ziprasidone
[Geodon]
Which antipsychotic is the least sedating? - answer- Risperidone [Risperdal]
What are the AE associated with dopaminergic blockade in patients on antipsychotics? - answer-
1. Extrapyramidal sx - TD, NMS, akathisia (typicals!)
2. Galactorrhea, gynecomastia, amenorrhea 2' to elevated prolactin
A nurse is educating a group of high school students about mental illness. Which of the
following statements should the nurse make about etiology of a mental illness?
a. "Schizophrenia can be detected through a complete blood count."
b. "It is possible to predict the likelihood of developing manifestations of a mental illness."
c. "Developing a mental illness seems to be related to both genetic and environmental factors."
d. "Regular physical examinations are commonly used to diagnose mental illness." - answer-
c. "Developing a mental illness seems to be related to both genetic and environmental
factors."
