FULL TEST BANK
TEST BANK FOR JANEWAY'S
IMMUNOBIOLOGY 9TH EDITION BY
KENNETH MURPHY; CASEY WEAVER
PRINTED PDF | ORIGINAL DIRECTLY FROM THE PUBLISHER | 100%
VERIFIED ANSWERS | DOWNLOAD IMMEDIATELY AFTER THE ORDER
,TABLE OF CONTENTS
Chapter 01. Basic Concepts In Immunology 1
Chapter 02. Innate Immunity The First Lines Of Defense 21
Chapter 03. The Induced Responses Of Innate Immunity 40
Chapter 04. Antigen Recognition By B-Cell And T-Cell Receptors 62
Chapter 05. The Generation Of Lymphocyte Antigen Receptors 78
Chapter 06. Antigen Presentation To T Lymphocytes 99
Chapter 07. Lymphocyte Receptor Signaling 121
Chapter 08. The Development Of B And T Lymphocytes 142
Chapter 09. T-Cell-Mediated Immunity 165
Chapter 10. The Humoral Immune Response 188
Chapter 11. Integrated Dynamics Of Innate And Adaptive Immunity 207
Chapter 12. The Mucosal Immune System 227
Chapter 13. Failures Of Host Defense Mechanisms 244
Chapter 14. Allergy And Allergic Diseases 272
Chapter 15. Autoimmunity And Transplantation 290
Chapter 16. Manipulation Of The Immune Response 314
, JANEWAY'S IMMUNOBIOLOGY, 9TH EDITION
CHAPTER 1: BASIC CONCEPTS IN IMMUNOLOGY
The origins of vertebrate immune cells
1.1 Multiple choice: in patients with lymphomas, the cancer cells invade the bone
marrow and destroy the environment required for normal hematopoiesis. This leads to
bone marrow failure, which disrupts the production of hematopoietic cell lineages. All
of the following cell types would be affected by this except:
A. Red blood cells
B. Macrophages
C. Lymphocytes
D. Endothelial cells
E. Ranulocytes
Principles of innate immunity
1-1 Commensal organisms cause little host damage while pathogens damage
host tissues by a variety of mechanisms
1.2 True/false: our immune system efficiently kills all categories of microbes that
attempt to colonize our bodies.
1.3 Short answer: pathogenic organisms cause damage to the host by a variety of
mechanisms, depending on t he wc w
a t we g.otr ybosf mt h.e wp sa thogen and its mode of
replication in
The host. Give an example of two different types of pathogens that are unlikely to
Be dealt with by the same mechanism of immune protection.
1-2 Anatomic and chemical barriers are the first defense against pathogens
1.4 Multiple choice: the skin and bodily secretions provide the first line of defense
against infection. One response in this category that is common during upper
respiratory virus infections is:
A. Production of antibodies
B. Infiltration by white blood cells
C. Mucus production
D. Increased saliva production
E. Fever
1-3 The immune system is activated by inflammatory inducers that indicate the
presence of pathogens or tissue damage
1.5 Short answer: a common mechanism by which sensor cells in the host detect micro-
organisms relies on the production of unique microbial components not found in the
host. Propose a strategy by which a clever microbe could evade this type of response.
1.6 Multiple choice: adaptive immune responses are slow to develop, taking days to
weeks after exposure to reach their peak. However, these responses are more
specific than innate responses, and also generate immunological memory. These
latter features,
1|page
, Which provide enhanced protection upon re-infection with the same pathogen, are the
basis of:
A. Vaccines
B. Antibiotics
C. Systemic shock
D. Complement activation
E. Phagocytosis
1-4 The myeloid lineage comprises most of the cells of the innate immune system
1.7 True/false: in the absence of an infection, most granulocytes (neutrophils, eosinophils,
basophils) are found circulating in the blood, whereas other subsets of myeloid cells
reside in tissues.
1.8 Short answer: dendritic cells are phagocytic, but also capable of ingesting large
amounts of extracellular fluid and its contents, a process known as macropinocytosis.
What specialized function do dendritic cells have in immunity that might account for
their need to perform macropinocytosis?
1-5 Sensor cells express pattern recognition receptors that provide an
initial discrimination between self and nonself
1.9 Multiple choice: some pattern recognition receptors (prrs) recognize nucleic acids, like
rna or dna. Since our own cells contain human rna and dna, the activation of innate
immune pathways by these prrs must rely on additional criteria to discriminate
Self from nonself. Additional c r i t w
e rw
i awi n.ctl ubd es m
e v.ewr yst hing except:
A. The subcellular location of the rna
B. The presence of adenosine residues in viral rna
C. The methylation state of the dna
D. Unique structures found on viral rna
E. The subcellular location of the dna
1-6 Sensor cells induce an inflammatory response by producing mediators such
as chemokines and cytokines
1.10 Multiple choice: when macrophages in a tissue encounter bacteria, they release
cytokines that induce an inflammatory response. These cytokines act on other
immune cells, to recruit them to the site of infection and to enhance their activities. In
addition, these cytokines act on the endothelial cells of the blood vessel wall to:
A. Increase their permeability, allowing fluid and proteins to leak into the tissue
B. Solidify the tight junctions to prevent the bacteria from entering the blood
C. Proliferate, allowing the blood vessel to enlarge
D. Up-regulate microbicidal mechanisms, so they can kill bacteria
E. Secrete anti-microbial peptides
1.11 Short answer: a common characteristic of a site of infection, such as a pimple on
the skin, is pus. What is responsible for the white color of pus?
1-7 Innate lymphocytes and natural killer cells are effector cells that share
similarities with lymphoid lineages of the adaptive immune system
2|page
TEST BANK FOR JANEWAY'S
IMMUNOBIOLOGY 9TH EDITION BY
KENNETH MURPHY; CASEY WEAVER
PRINTED PDF | ORIGINAL DIRECTLY FROM THE PUBLISHER | 100%
VERIFIED ANSWERS | DOWNLOAD IMMEDIATELY AFTER THE ORDER
,TABLE OF CONTENTS
Chapter 01. Basic Concepts In Immunology 1
Chapter 02. Innate Immunity The First Lines Of Defense 21
Chapter 03. The Induced Responses Of Innate Immunity 40
Chapter 04. Antigen Recognition By B-Cell And T-Cell Receptors 62
Chapter 05. The Generation Of Lymphocyte Antigen Receptors 78
Chapter 06. Antigen Presentation To T Lymphocytes 99
Chapter 07. Lymphocyte Receptor Signaling 121
Chapter 08. The Development Of B And T Lymphocytes 142
Chapter 09. T-Cell-Mediated Immunity 165
Chapter 10. The Humoral Immune Response 188
Chapter 11. Integrated Dynamics Of Innate And Adaptive Immunity 207
Chapter 12. The Mucosal Immune System 227
Chapter 13. Failures Of Host Defense Mechanisms 244
Chapter 14. Allergy And Allergic Diseases 272
Chapter 15. Autoimmunity And Transplantation 290
Chapter 16. Manipulation Of The Immune Response 314
, JANEWAY'S IMMUNOBIOLOGY, 9TH EDITION
CHAPTER 1: BASIC CONCEPTS IN IMMUNOLOGY
The origins of vertebrate immune cells
1.1 Multiple choice: in patients with lymphomas, the cancer cells invade the bone
marrow and destroy the environment required for normal hematopoiesis. This leads to
bone marrow failure, which disrupts the production of hematopoietic cell lineages. All
of the following cell types would be affected by this except:
A. Red blood cells
B. Macrophages
C. Lymphocytes
D. Endothelial cells
E. Ranulocytes
Principles of innate immunity
1-1 Commensal organisms cause little host damage while pathogens damage
host tissues by a variety of mechanisms
1.2 True/false: our immune system efficiently kills all categories of microbes that
attempt to colonize our bodies.
1.3 Short answer: pathogenic organisms cause damage to the host by a variety of
mechanisms, depending on t he wc w
a t we g.otr ybosf mt h.e wp sa thogen and its mode of
replication in
The host. Give an example of two different types of pathogens that are unlikely to
Be dealt with by the same mechanism of immune protection.
1-2 Anatomic and chemical barriers are the first defense against pathogens
1.4 Multiple choice: the skin and bodily secretions provide the first line of defense
against infection. One response in this category that is common during upper
respiratory virus infections is:
A. Production of antibodies
B. Infiltration by white blood cells
C. Mucus production
D. Increased saliva production
E. Fever
1-3 The immune system is activated by inflammatory inducers that indicate the
presence of pathogens or tissue damage
1.5 Short answer: a common mechanism by which sensor cells in the host detect micro-
organisms relies on the production of unique microbial components not found in the
host. Propose a strategy by which a clever microbe could evade this type of response.
1.6 Multiple choice: adaptive immune responses are slow to develop, taking days to
weeks after exposure to reach their peak. However, these responses are more
specific than innate responses, and also generate immunological memory. These
latter features,
1|page
, Which provide enhanced protection upon re-infection with the same pathogen, are the
basis of:
A. Vaccines
B. Antibiotics
C. Systemic shock
D. Complement activation
E. Phagocytosis
1-4 The myeloid lineage comprises most of the cells of the innate immune system
1.7 True/false: in the absence of an infection, most granulocytes (neutrophils, eosinophils,
basophils) are found circulating in the blood, whereas other subsets of myeloid cells
reside in tissues.
1.8 Short answer: dendritic cells are phagocytic, but also capable of ingesting large
amounts of extracellular fluid and its contents, a process known as macropinocytosis.
What specialized function do dendritic cells have in immunity that might account for
their need to perform macropinocytosis?
1-5 Sensor cells express pattern recognition receptors that provide an
initial discrimination between self and nonself
1.9 Multiple choice: some pattern recognition receptors (prrs) recognize nucleic acids, like
rna or dna. Since our own cells contain human rna and dna, the activation of innate
immune pathways by these prrs must rely on additional criteria to discriminate
Self from nonself. Additional c r i t w
e rw
i awi n.ctl ubd es m
e v.ewr yst hing except:
A. The subcellular location of the rna
B. The presence of adenosine residues in viral rna
C. The methylation state of the dna
D. Unique structures found on viral rna
E. The subcellular location of the dna
1-6 Sensor cells induce an inflammatory response by producing mediators such
as chemokines and cytokines
1.10 Multiple choice: when macrophages in a tissue encounter bacteria, they release
cytokines that induce an inflammatory response. These cytokines act on other
immune cells, to recruit them to the site of infection and to enhance their activities. In
addition, these cytokines act on the endothelial cells of the blood vessel wall to:
A. Increase their permeability, allowing fluid and proteins to leak into the tissue
B. Solidify the tight junctions to prevent the bacteria from entering the blood
C. Proliferate, allowing the blood vessel to enlarge
D. Up-regulate microbicidal mechanisms, so they can kill bacteria
E. Secrete anti-microbial peptides
1.11 Short answer: a common characteristic of a site of infection, such as a pimple on
the skin, is pus. What is responsible for the white color of pus?
1-7 Innate lymphocytes and natural killer cells are effector cells that share
similarities with lymphoid lineages of the adaptive immune system
2|page
