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HESI RN Exit Exam 2026 Comprehensive Study Guide – Gastrointestinal, Cardiovascular, Respiratory, Neurological, Endocrine, and Nursing Management Review

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This comprehensive study guide covers essential topics for the HESI RN Exit Exam, including gastrointestinal disorders, cardiovascular conditions, respiratory care, neurological and mental health, endocrine imbalances, and fluid and electrolyte management. It also includes key nursing interventions, pharmacology considerations, infection control practices, perioperative care, and delegation principles frequently tested on the exam. The material is structured in a question-and-answer format with detailed rationales to reinforce clinical reasoning and prioritization skills. It is ideal for final exam preparation and NCLEX-style review, helping students identify critical concepts, recognize complications, and apply safe nursing practices across multiple patient scenarios.

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HESI RN EXIT EXAM
COMPREHENSIVE
STUDY GUIDE

SECTION 1: GASTROINTESTINAL & NUTRITION



QUESTION 1

Client with duodenal ulcer says he will drink plenty of dairy products to coat and protect his
ulcer. Best follow-up action?

ANSWER

Review with the client the need to avoid foods rich in milk and cream

RATIONALE / EXPLANATION

Milk and cream stimulate gastric acid secretion and should be avoided. Also avoid caffeine.



QUESTION 2

Client taking tetracycline complains of GI upset. What snack to take with the medication?

ANSWER

Toasted wheat bread and jelly

RATIONALE / EXPLANATION

Dairy products decrease tetracycline effectiveness. Toast with no dairy may decrease GI
symptoms.



QUESTION 3

Antibiotic cephradine prescribed for postoperative wound infection. Which food to
encourage?

ANSWER

D. Cinnamon applesauce

RATIONALE / EXPLANATION



Page 1 of 30

,Dairy products and calcium-fortified foods decrease absorption of ciprofloxacin. Applesauce has
no calcium.



QUESTION 4

Client on warfarin (Coumadin). What dietary instruction?

ANSWER

Eat approximately the same amount of leafy green vegetables daily so vitamin
K consumed is consistent

RATIONALE / EXPLANATION

Coumadin dose is adjusted based on normal vitamin K consumption. Keep intake consistent,
don't eliminate or increase.



QUESTION 5

Pregnant client complaining of heartburn. Best instruction?

ANSWER

Eat small meals throughout the day to avoid a full stomach

RATIONALE / EXPLANATION

Small frequent meals decrease stomach fullness and heartburn. Avoid antacids in pregnancy
unless prescribed.



QUESTION 6

Client with small bowel resection has diarrhea. No BM for 3 days but now frequent small
liquid stools. Action?

ANSWER

Digitally check the client for a fecal impaction

RATIONALE / EXPLANATION

Liquid stool around impaction is classic sign of fecal impaction - seepage of liquid around the
solid mass.




Page 2 of 30

, SECTION 2: CARDIOVASCULAR & HEMODYNAMICS



QUESTION 7

Client with hypertension not taking meds because they make him 'feel bad.' What risk to
stress?

ANSWER

Stroke secondary to hemorrhage

RATIONALE / EXPLANATION

Stroke from cerebral hemorrhage is the major risk of uncontrolled hypertension.



QUESTION 8

After placing stethoscope for S1 and S2, what action to determine if S3 is present?

ANSWER

Listen with the bell at the same location

RATIONALE / EXPLANATION

The bell auscultates low-pitched sounds like S3 and S4. Listen at same site with bell before
moving to next location.



QUESTION 9

Client with heart failure has nausea, vomiting, yellow vision, palpitations. Most important
assessment?

ANSWER

Obtain a list of medications taken for cardiac history

RATIONALE / EXPLANATION

These are signs of digitalis toxicity. Medication list will likely include digoxin (Lanoxin) - confirm
with serum level >2 mg/ml.



QUESTION 10



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April 26, 2026
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