PBSI 333 Exam 3 Questions With
Accurate Answers
Please indicate which of the following is true for alpha 1 subtype adrenergic
receptors:
a. located on serotonergic terminals
b. located in the sympathetic system where it controls urinary retention
c. signals via stimulation of adenylyl cyclase
d. A and C - ANSWER b. located in the sympathetic system where it controls
urinary retention
Which of the following disorders is more common in women:
a. Bipolar I
b. GAD
c. MDD
d. All of the above
e. A and B
f. B and C - ANSWER f. B and C
Please indicate which of the following statement(s) is (are) true:
a. Suicidal ideation is hypothesized to be driven, at least in part, by
abnormalities in norepinephrine tone in the ventral medical prefrontal cortex
and the amygdala.
b. Anhedonia is hypothesized to be driven, at least in part, by abnormalities in
dopamine tone in the nucleus accumbens.
c. Executive dysfunction is hypothesized to be driven, at least in part, by
abnormalities in serotonin tone in the hypothalamus.
d. All of the above
e. A and B
f. B and C - ANSWER b. Anhedonia is hypothesized to be driven, at least in part,
by abnormalities in dopamine tone in the nucleus accumbens.
Please indicate which of the following is true for the mechanism of action of
SARIs:
a. Antagonism of 5HT2A receptor potentiates the inhibitory action of 5HT1A
receptor on glutamate release by some pyramidal neurons
b. Disinhibition of 5HT2A and 5HT2C on DA and NE release
, c. Increase serotonin levels via alpha 2 antagonism
d. All of the above
e. A and B
f. A and C - ANSWER e. A and B
Please indicate which of the following is a risk factor to develop PTSD:
a. Carrying the 5-HTT short allele
b. Earlier age at the time of the traumatic event
c. Bigger hippocampus size
d. All of the above
e. A and B
f. B and C - ANSWER e. A and B
Please indicate which of the following is true for the monoamine receptor
hypothesis:
a. The monoamine receptor hypothesis of depression suggest that depression is
caused by an absence of a key monoamine receptor in the brain
b. According to the monoamine receptor hypothesis, the mechanism of
therapeutic action of the SSRI is down-regulation of the somatodendritic 5-HT1D
autoreceptors
c. The monoamine receptor hypothesis is supported by the fact the elevation of
serotonin levels by SSRIs first observed in the cortex and later on in the raphe
nucleus
d. None of the above - ANSWER d. None of the above
Which of the following combination of subunits believed to create the binding
site for BZDs:
a. alpha1 and beta2
b. alpha2 and gamma2
c. alpha1 and beta1
d. alpha1 and alpha2 - ANSWER b. alpha2 and gamma2
GAD stands for:
a. Generalized anxiety depression
b. Glutamic acid decarboxylase
c. Generalized anxiety disorders
d. All of the above
e. A and B
f. B and C - ANSWER f. B and C
Please indicate which of the following enzymes are found in noradrenergic
neurons:
Accurate Answers
Please indicate which of the following is true for alpha 1 subtype adrenergic
receptors:
a. located on serotonergic terminals
b. located in the sympathetic system where it controls urinary retention
c. signals via stimulation of adenylyl cyclase
d. A and C - ANSWER b. located in the sympathetic system where it controls
urinary retention
Which of the following disorders is more common in women:
a. Bipolar I
b. GAD
c. MDD
d. All of the above
e. A and B
f. B and C - ANSWER f. B and C
Please indicate which of the following statement(s) is (are) true:
a. Suicidal ideation is hypothesized to be driven, at least in part, by
abnormalities in norepinephrine tone in the ventral medical prefrontal cortex
and the amygdala.
b. Anhedonia is hypothesized to be driven, at least in part, by abnormalities in
dopamine tone in the nucleus accumbens.
c. Executive dysfunction is hypothesized to be driven, at least in part, by
abnormalities in serotonin tone in the hypothalamus.
d. All of the above
e. A and B
f. B and C - ANSWER b. Anhedonia is hypothesized to be driven, at least in part,
by abnormalities in dopamine tone in the nucleus accumbens.
Please indicate which of the following is true for the mechanism of action of
SARIs:
a. Antagonism of 5HT2A receptor potentiates the inhibitory action of 5HT1A
receptor on glutamate release by some pyramidal neurons
b. Disinhibition of 5HT2A and 5HT2C on DA and NE release
, c. Increase serotonin levels via alpha 2 antagonism
d. All of the above
e. A and B
f. A and C - ANSWER e. A and B
Please indicate which of the following is a risk factor to develop PTSD:
a. Carrying the 5-HTT short allele
b. Earlier age at the time of the traumatic event
c. Bigger hippocampus size
d. All of the above
e. A and B
f. B and C - ANSWER e. A and B
Please indicate which of the following is true for the monoamine receptor
hypothesis:
a. The monoamine receptor hypothesis of depression suggest that depression is
caused by an absence of a key monoamine receptor in the brain
b. According to the monoamine receptor hypothesis, the mechanism of
therapeutic action of the SSRI is down-regulation of the somatodendritic 5-HT1D
autoreceptors
c. The monoamine receptor hypothesis is supported by the fact the elevation of
serotonin levels by SSRIs first observed in the cortex and later on in the raphe
nucleus
d. None of the above - ANSWER d. None of the above
Which of the following combination of subunits believed to create the binding
site for BZDs:
a. alpha1 and beta2
b. alpha2 and gamma2
c. alpha1 and beta1
d. alpha1 and alpha2 - ANSWER b. alpha2 and gamma2
GAD stands for:
a. Generalized anxiety depression
b. Glutamic acid decarboxylase
c. Generalized anxiety disorders
d. All of the above
e. A and B
f. B and C - ANSWER f. B and C
Please indicate which of the following enzymes are found in noradrenergic
neurons:
