Test Bank for Pathophysiology for
Advanced Practice, 1st Edition by
Workman (Rationales Included)
Neuroanatomic and neurotransmitter alterations in the pathophysiology of schizophrenia
include which of the following?
A) Loss of cortical tissue
B) Alteration in dopamine pathways
C) Shrinkage of the ventricles
D) All of these are correct.
E) Loss of cortical tissue and alteration in dopamine pathways - answer-E
A patient reports that he senses that he is detached from society. His family reports he doesn't
seem to enjoy many experiences. These symptoms are a description of:
A) avolition.
B) alogia.
C) anhedonia.
D) delusions. - answer-C
Which of the following neurotransmitters is widely reduced in depression?
A) Serotonin
B) Monoamine
C) Glutamine
1
,D) Epinephrine - answer-A
An 18-year-old was brought into the emergency room because she was found on the streets at
2:00 a.m. stating she was campaigning for the next president and was writing his speeches.
Police reported she was alone and yelling at oncoming cars and insisting they join her campaign
to elect the next president. Concerns for her safety is what led the police to bring her to the
emergency room. This woman may be experiencing:
A) a manic episode.
B) a panic attack.
C) agoraphobia.
D) compulsive behavior. - answer-A
In a generalized anxiety disorder, anticipatory anxiety and attentional bias to threats are
thought be caused by:
A) serotonin and GABA surges.
B) cingulate cortex and amygdala abnormalities.
C) cholecystokinin receptor gene on chromosome 11p.
D) hypothalamic-pituitary thyroid system dysregulation. - answer-B
A patient with schizophrenia has hallucinations and delusions. These thoughts and behaviors
are termed:
A) positive symptoms.
B) negative symptoms.
C) affective symptoms.
D) cognitive symptoms. - answer-A
2
,Second-generation antipsychotics have which of the following effects on neurotransmitters?
A) Dopamine and serotonin
B) Dopamine only
C) Serotonin only
D) Dopamine and glutamate - answer-A
A patient with refractory depression will receive electroconvulsive therapy. She would like more
information about this therapy. What information should be provided to her?
A) You will need to be on bedrest for 2 days after the procedure.
B) The procedure produces a brief brain seizure that activates various brain areas.
C) The procedure is painless, so usually no anesthesia is necessary.
D) You will have to reduce your intake of food after, due to the risk of vomiting. - answer-B
What symptoms must be present for a patient to be diagnosed with major depressive disorder?
A) Indecisiveness
B) Feeling of sadness
C) Fatigue
D) Insomnia - answer-B
An 18-year-old patient describes that he needs to wash his hands multiple times a day because
he is concerned about germs. He said this started when he was about 12 years old. This
behavior is a description of:
A) an obsession.
B) a compulsion.
C) paranoia.
3
, D) delusions. - answer-B
Alterations in __________ have been associated with the development of mental health
disorders such as depression, bipolar disorder, and schizophrenia.
A) chromosomes 8 and 15
B) chromosomes 5 and 6
C) chromosomes 1 and 2
D) chromosomes 3 and 10 - answer-D
What is the relationship between the hypothalamic pituitary axis and depression?
A) Reduction in cortisol
B) Reduced production of corticotropin-releasing hormone
C) Increased production of corticotropin-releasing hormone
D) Low levels of gamma aminobutyric acid - answer-C
Which of the following essential amino acids is a precursor to serotonin?
A) Tryptophan
B) Glutamate
C) Choline
D) Dopamine - answer-A
30-year-old male patient is in the emergency room because he was belligerent, confused, and
delirious. His girlfriend called the police because of this behavior, and she said it started after
smoking marijuana. Suspicions are that the marijuana was altered with phencyclidine (PCP).
Which receptors are mainly altered by PCP?
A) N-methyl-D-aspartate (NMDA)
4
Advanced Practice, 1st Edition by
Workman (Rationales Included)
Neuroanatomic and neurotransmitter alterations in the pathophysiology of schizophrenia
include which of the following?
A) Loss of cortical tissue
B) Alteration in dopamine pathways
C) Shrinkage of the ventricles
D) All of these are correct.
E) Loss of cortical tissue and alteration in dopamine pathways - answer-E
A patient reports that he senses that he is detached from society. His family reports he doesn't
seem to enjoy many experiences. These symptoms are a description of:
A) avolition.
B) alogia.
C) anhedonia.
D) delusions. - answer-C
Which of the following neurotransmitters is widely reduced in depression?
A) Serotonin
B) Monoamine
C) Glutamine
1
,D) Epinephrine - answer-A
An 18-year-old was brought into the emergency room because she was found on the streets at
2:00 a.m. stating she was campaigning for the next president and was writing his speeches.
Police reported she was alone and yelling at oncoming cars and insisting they join her campaign
to elect the next president. Concerns for her safety is what led the police to bring her to the
emergency room. This woman may be experiencing:
A) a manic episode.
B) a panic attack.
C) agoraphobia.
D) compulsive behavior. - answer-A
In a generalized anxiety disorder, anticipatory anxiety and attentional bias to threats are
thought be caused by:
A) serotonin and GABA surges.
B) cingulate cortex and amygdala abnormalities.
C) cholecystokinin receptor gene on chromosome 11p.
D) hypothalamic-pituitary thyroid system dysregulation. - answer-B
A patient with schizophrenia has hallucinations and delusions. These thoughts and behaviors
are termed:
A) positive symptoms.
B) negative symptoms.
C) affective symptoms.
D) cognitive symptoms. - answer-A
2
,Second-generation antipsychotics have which of the following effects on neurotransmitters?
A) Dopamine and serotonin
B) Dopamine only
C) Serotonin only
D) Dopamine and glutamate - answer-A
A patient with refractory depression will receive electroconvulsive therapy. She would like more
information about this therapy. What information should be provided to her?
A) You will need to be on bedrest for 2 days after the procedure.
B) The procedure produces a brief brain seizure that activates various brain areas.
C) The procedure is painless, so usually no anesthesia is necessary.
D) You will have to reduce your intake of food after, due to the risk of vomiting. - answer-B
What symptoms must be present for a patient to be diagnosed with major depressive disorder?
A) Indecisiveness
B) Feeling of sadness
C) Fatigue
D) Insomnia - answer-B
An 18-year-old patient describes that he needs to wash his hands multiple times a day because
he is concerned about germs. He said this started when he was about 12 years old. This
behavior is a description of:
A) an obsession.
B) a compulsion.
C) paranoia.
3
, D) delusions. - answer-B
Alterations in __________ have been associated with the development of mental health
disorders such as depression, bipolar disorder, and schizophrenia.
A) chromosomes 8 and 15
B) chromosomes 5 and 6
C) chromosomes 1 and 2
D) chromosomes 3 and 10 - answer-D
What is the relationship between the hypothalamic pituitary axis and depression?
A) Reduction in cortisol
B) Reduced production of corticotropin-releasing hormone
C) Increased production of corticotropin-releasing hormone
D) Low levels of gamma aminobutyric acid - answer-C
Which of the following essential amino acids is a precursor to serotonin?
A) Tryptophan
B) Glutamate
C) Choline
D) Dopamine - answer-A
30-year-old male patient is in the emergency room because he was belligerent, confused, and
delirious. His girlfriend called the police because of this behavior, and she said it started after
smoking marijuana. Suspicions are that the marijuana was altered with phencyclidine (PCP).
Which receptors are mainly altered by PCP?
A) N-methyl-D-aspartate (NMDA)
4
