UAMS Spring Immunohematology Exam 1 Test with Answers Rated A
1. Intravascular Hemoly- Cell membrane is destroyed by complement (not antibody)
sis
2. Extravascular hemoly- Antibody attaches to the membrane
sis
3. Which hemolysis is Intravascular hemolysis
more severe?
4. Which hemolysis is con- extravascular hemolysis
sidered a delayed trans-
fusion rxn?
5. What happens in in- Cells are destroyed and kidneys get damaged due to cell fragments
travascular hemolysis?
6. ABO incompatible intravascular hemolysis
transfusion is caused by
7. HDFN is caused by Extravascular hemolysis
8. Humoral immunity Antibody mediated; produced by B cells; found in plasma, saliva, and
bodily secretions.
9. Antibody and comple- Complement lysis Ab coated cells; serves to mediate opsonization to
ment prepare for phagocytosis; cell coated with Ab, then either destroyed by
phagocytosis, complement or removed by the spleen
10. cellular immunity Cell mediates; direct interaction of T lymphs with foreign cells;
macrophages, T cells, Dendritic cells; Delayed hypersensitivity and
transplant immunology
11. Production of
cyto/chemokines
, UAMS Spring Immunohematology Exam 1 Test with Answers Rated A
Chemotactic factors and mediators of inflammation; CD4 cells transform
B cells into plasma cells; CD8 cells suppress Ab formation to auto Ag; NK
cells cause death by lysis
12. Epitopes Portion of AGN where ABY binds; Antigenic determinant
13. AGNs are acquired Injection, inhalation, or ingestion
through
14. Avidity overall strength of reaction between several epitopes and ABYs
15. Affinity Strength of a single AGN-ABY bond produced by summation of attractive
and repulsive forces
16. Antibodies Proteins synthesized by plasma cells; production initiated following
direct interaction of AGN with macrophages
17. Alloantibody immune antibody against foreign antigen of the same species
18. Autoantibody antibody produced in response to an antigen from the host's own tissue
19. Structure of ABY four polypeptide chains joined by disulfide bond; two heavy chains and
two light chains
20. Heavy chains IgG, IgM, IgA, IgD, IgE
21. Light chains Kappa and Lambda
22. FAB portion fragment antigen binding; structured according to the variation of ABY
specificity; binds to AGN determinant
23. Fc portion binding site for complement or macrophage Fc receptors
24. Enzyme cleavage pepsin and papain split ABY at hinge ( disulfide bond ) into Fc and Fab
1. Intravascular Hemoly- Cell membrane is destroyed by complement (not antibody)
sis
2. Extravascular hemoly- Antibody attaches to the membrane
sis
3. Which hemolysis is Intravascular hemolysis
more severe?
4. Which hemolysis is con- extravascular hemolysis
sidered a delayed trans-
fusion rxn?
5. What happens in in- Cells are destroyed and kidneys get damaged due to cell fragments
travascular hemolysis?
6. ABO incompatible intravascular hemolysis
transfusion is caused by
7. HDFN is caused by Extravascular hemolysis
8. Humoral immunity Antibody mediated; produced by B cells; found in plasma, saliva, and
bodily secretions.
9. Antibody and comple- Complement lysis Ab coated cells; serves to mediate opsonization to
ment prepare for phagocytosis; cell coated with Ab, then either destroyed by
phagocytosis, complement or removed by the spleen
10. cellular immunity Cell mediates; direct interaction of T lymphs with foreign cells;
macrophages, T cells, Dendritic cells; Delayed hypersensitivity and
transplant immunology
11. Production of
cyto/chemokines
, UAMS Spring Immunohematology Exam 1 Test with Answers Rated A
Chemotactic factors and mediators of inflammation; CD4 cells transform
B cells into plasma cells; CD8 cells suppress Ab formation to auto Ag; NK
cells cause death by lysis
12. Epitopes Portion of AGN where ABY binds; Antigenic determinant
13. AGNs are acquired Injection, inhalation, or ingestion
through
14. Avidity overall strength of reaction between several epitopes and ABYs
15. Affinity Strength of a single AGN-ABY bond produced by summation of attractive
and repulsive forces
16. Antibodies Proteins synthesized by plasma cells; production initiated following
direct interaction of AGN with macrophages
17. Alloantibody immune antibody against foreign antigen of the same species
18. Autoantibody antibody produced in response to an antigen from the host's own tissue
19. Structure of ABY four polypeptide chains joined by disulfide bond; two heavy chains and
two light chains
20. Heavy chains IgG, IgM, IgA, IgD, IgE
21. Light chains Kappa and Lambda
22. FAB portion fragment antigen binding; structured according to the variation of ABY
specificity; binds to AGN determinant
23. Fc portion binding site for complement or macrophage Fc receptors
24. Enzyme cleavage pepsin and papain split ABY at hinge ( disulfide bond ) into Fc and Fab
