MCB 450 exam 4 study guide UPDATED ACTUAL Questions And Correct
Answers
C
Terms in this set (118)
Why do lipoproteins (e.g. VLDL) only have a monolayer of C. The acyl chains of the phospholipid monolayer interact with triglycerides and
phospholipids instead of a typical lipid bilayer? cholesterol esters of the particle
A. The phosphate of the lipids interact with the
triglycerides and cholesterol esters of the particle.
B. The monolayer protects the particles from bile acids
C. The acyl chains of the phospholipid monolayer interact
with the triglycerides and cholesterol esters of the
particle.
D. The glycerol backbone solubilize the triglycerides
E. The monolayer blocks proteases from degrading the
particles
Odd chain fatty acids and some amino acids produce NADH
propionyl CoA. Which of the following is NOT required
for the metabolism of propionyl CoA to succinyl CoA
A. NADH
B. Propionyl CoA carboxylase
C. Methylmalonyl CoA mutase
D. Vitamin B12
E. Biotin
Human can convert cholesterol to each of the following, CO2 and H20
except;
A. CO2 + H2O
B. Cortisol
C. Testosterone
D. Estradiol
E. Bile acids
,Mammalian pyruvate dehydrogenase component E1 is D. High Acetyl-CoA
inactivated through phosphorylation in the presence of
_______?
A. High ADP
B. High pyruvate
C. Insulin
D. High Acetyl-CoA
E. High AMP
Lovastatin is used to lower cholesterol by inhibiting the A. HMG-CoA reductase
function of which protein?
A. HMG-CoA reductase
B. LDL receptor
C. Lipoprotein lipase
D. Cyclooxygenase
E. Alcohol dehydrogenase
During vigorous exercise, stimulation of the tricarboxylic C. Stimulation of the flux through a number of TCA cycle enzymes by a decreased
acid (TCA) cycle results principally from _____? NADH/NAD+ ratio
A. Allosteric activation of a number of TCA cycle
enzymes by increased levels of NADH
B. Allosteric activation of fumarase by increased cellular
ADP concentrations
C. Stimulation of the flux through a number of TCA cycle
enzymes by a decreased NADH/NAD+ ratio
D. A rapid decrease in the concentration of four carbon
intermediates being used by other metabolic pathways,
e.g. gluconeogenesis
E. Product inhibition of the citrate synthase enzyme,
which blocks the condensation of Acetyl CoA and
oxaloacetate
Triacylglycerol synthesis in adipose tissue occurs only in D. Adipose tissue lacks glycerol kinase to make glycerol-3-phosphate from
the fed state. Why? glycerol. Therefore, Glycerol 3-phosphate can only be obtained from the
A. Coenzyme A being required to activate the fatty acids glycolytic pathway (fed state) and the reduction of DHAP
prior to coupling to glycerol-3 phosphate
B. Lipoprotein lipase being activated only in the fed state
by Apo-CII
C. Fatty acid for triacylglycerol synthesis being obtained
from chylomicrons and VLDL, which is high in
concentration after a meal with high fat content
D. Adipose tissue lacks glycerol kinase to make glycerol-
3-phosphate from glycerol. Therefore, Glycerol-3-
phosphate can only be obtained from the glycolytic
pathway (fed state), and the reduction of
dihydroxyacetone phosphate (DHAP)
E. None of the above.
, A patient with a genetic defect in lipoprotein lipase D. Elevated chylomicrons in fasting blood samples
would be expected to exhibit which of the following?
A. A deficiency in release of fatty acids from adipocytes
during fasting
B. Elevated glucose in fasting blood samples
C. Elevated intestinal absorption of fats
D. Elevated chylomicrons in fasting blood samples
E. Decreasing recycling of bile salts
Suppose 14-C labeled CO2 is used to form malonyl CoA E. none of the carbons
from acetyl CoA. if this labeled malonyl CoA is used for
palmitate synthesis, which carbons in the fatty acid would
be radiolabeled?
A. The methyl terminal carbon
B. Only the alpha and beta-carbons
C. All odd numbered carbons
D. All even numbered carbons
E. None of the carbons
Fatty acids are adenylated prior to reacting with A. this creates a phospho ester bond that can be attacked by Coenzyme A
Coenzyme A to make Acyl-CoA. What is the purpose of
the adenylation?
A. This creates a phospho-ester bond that can be
"attacked" by Coenzyme A
B. Adenylation prevents Acyl-CoA from interacting with
coenzyme A
C. Adenylation leads to the addition of ATP to the acyl
chains
D. This allows for the growth of acyl chain length
E. All of the above
The carnitine derivatives of fatty acids are utilized for B. Shuttling fatty acids across the mitochondrial membrane
A. Carrying fatty acids during fatty acid synthesis
B. Shuttling fatty acids across the mitochondrial
membrane
C. One of the intermediates during beta-oxidation
D. Transporting fatty acids across the plasma membrane
of the cell
E. Transporting fatty acids in plasma
Which of the following compounds is a potent stimulator C. Citrate
of palmitate synthesis, an allosteric activator of acetyl-
CoA carboxylase, and a source of both cytoplasmic
acetyl-CoA and NADPH for lipogenesis?
A. Biotin
B. Glucose 6-phosphate
C. Citrate
D. Pantothenic acid
E. L-carnitine
Answers
C
Terms in this set (118)
Why do lipoproteins (e.g. VLDL) only have a monolayer of C. The acyl chains of the phospholipid monolayer interact with triglycerides and
phospholipids instead of a typical lipid bilayer? cholesterol esters of the particle
A. The phosphate of the lipids interact with the
triglycerides and cholesterol esters of the particle.
B. The monolayer protects the particles from bile acids
C. The acyl chains of the phospholipid monolayer interact
with the triglycerides and cholesterol esters of the
particle.
D. The glycerol backbone solubilize the triglycerides
E. The monolayer blocks proteases from degrading the
particles
Odd chain fatty acids and some amino acids produce NADH
propionyl CoA. Which of the following is NOT required
for the metabolism of propionyl CoA to succinyl CoA
A. NADH
B. Propionyl CoA carboxylase
C. Methylmalonyl CoA mutase
D. Vitamin B12
E. Biotin
Human can convert cholesterol to each of the following, CO2 and H20
except;
A. CO2 + H2O
B. Cortisol
C. Testosterone
D. Estradiol
E. Bile acids
,Mammalian pyruvate dehydrogenase component E1 is D. High Acetyl-CoA
inactivated through phosphorylation in the presence of
_______?
A. High ADP
B. High pyruvate
C. Insulin
D. High Acetyl-CoA
E. High AMP
Lovastatin is used to lower cholesterol by inhibiting the A. HMG-CoA reductase
function of which protein?
A. HMG-CoA reductase
B. LDL receptor
C. Lipoprotein lipase
D. Cyclooxygenase
E. Alcohol dehydrogenase
During vigorous exercise, stimulation of the tricarboxylic C. Stimulation of the flux through a number of TCA cycle enzymes by a decreased
acid (TCA) cycle results principally from _____? NADH/NAD+ ratio
A. Allosteric activation of a number of TCA cycle
enzymes by increased levels of NADH
B. Allosteric activation of fumarase by increased cellular
ADP concentrations
C. Stimulation of the flux through a number of TCA cycle
enzymes by a decreased NADH/NAD+ ratio
D. A rapid decrease in the concentration of four carbon
intermediates being used by other metabolic pathways,
e.g. gluconeogenesis
E. Product inhibition of the citrate synthase enzyme,
which blocks the condensation of Acetyl CoA and
oxaloacetate
Triacylglycerol synthesis in adipose tissue occurs only in D. Adipose tissue lacks glycerol kinase to make glycerol-3-phosphate from
the fed state. Why? glycerol. Therefore, Glycerol 3-phosphate can only be obtained from the
A. Coenzyme A being required to activate the fatty acids glycolytic pathway (fed state) and the reduction of DHAP
prior to coupling to glycerol-3 phosphate
B. Lipoprotein lipase being activated only in the fed state
by Apo-CII
C. Fatty acid for triacylglycerol synthesis being obtained
from chylomicrons and VLDL, which is high in
concentration after a meal with high fat content
D. Adipose tissue lacks glycerol kinase to make glycerol-
3-phosphate from glycerol. Therefore, Glycerol-3-
phosphate can only be obtained from the glycolytic
pathway (fed state), and the reduction of
dihydroxyacetone phosphate (DHAP)
E. None of the above.
, A patient with a genetic defect in lipoprotein lipase D. Elevated chylomicrons in fasting blood samples
would be expected to exhibit which of the following?
A. A deficiency in release of fatty acids from adipocytes
during fasting
B. Elevated glucose in fasting blood samples
C. Elevated intestinal absorption of fats
D. Elevated chylomicrons in fasting blood samples
E. Decreasing recycling of bile salts
Suppose 14-C labeled CO2 is used to form malonyl CoA E. none of the carbons
from acetyl CoA. if this labeled malonyl CoA is used for
palmitate synthesis, which carbons in the fatty acid would
be radiolabeled?
A. The methyl terminal carbon
B. Only the alpha and beta-carbons
C. All odd numbered carbons
D. All even numbered carbons
E. None of the carbons
Fatty acids are adenylated prior to reacting with A. this creates a phospho ester bond that can be attacked by Coenzyme A
Coenzyme A to make Acyl-CoA. What is the purpose of
the adenylation?
A. This creates a phospho-ester bond that can be
"attacked" by Coenzyme A
B. Adenylation prevents Acyl-CoA from interacting with
coenzyme A
C. Adenylation leads to the addition of ATP to the acyl
chains
D. This allows for the growth of acyl chain length
E. All of the above
The carnitine derivatives of fatty acids are utilized for B. Shuttling fatty acids across the mitochondrial membrane
A. Carrying fatty acids during fatty acid synthesis
B. Shuttling fatty acids across the mitochondrial
membrane
C. One of the intermediates during beta-oxidation
D. Transporting fatty acids across the plasma membrane
of the cell
E. Transporting fatty acids in plasma
Which of the following compounds is a potent stimulator C. Citrate
of palmitate synthesis, an allosteric activator of acetyl-
CoA carboxylase, and a source of both cytoplasmic
acetyl-CoA and NADPH for lipogenesis?
A. Biotin
B. Glucose 6-phosphate
C. Citrate
D. Pantothenic acid
E. L-carnitine
