GU Men’s Health Study Guide Quiz 2026/2027
William Peterson University100/100(verified
Answers)
Section 1: Prostate Disorders (Questions 1–25)
1. A 58-year-old man presents with nocturia, hesitancy, and a weak stream. DRE reveals a
symmetrically enlarged, firm, non-tender prostate. PSA is 2.8 ng/mL. What is the most likely
diagnosis?
• A) Prostate cancer
• B) Acute bacterial prostatitis
• C) Benign prostatic hyperplasia (BPH)
• D) Chronic pelvic pain syndrome
Answer: C
Rationale: BPH typically presents with lower urinary tract symptoms (LUTS) and a
symmetrically enlarged prostate without tenderness. PSA is often normal or mildly elevated
(age-specific). Cancer is often asymmetrical or nodular; prostatitis would be tender.
2. Which medication class is first-line for moderate-to-severe BPH with bothersome LUTS?
• A) 5-alpha-reductase inhibitors
• B) Alpha-1 adrenergic antagonists
• C) Anticholinergics
• D) Phosphodiesterase-5 inhibitors
Answer: B
Rationale: Alpha-blockers (tamsulosin, alfuzosin) relax prostate smooth muscle, improving
flow quickly. 5-ARIs (finasteride) reduce prostate size but take months. PDE5Is are off-label
for LUTS.
, 3. A 72-year-old man on finasteride for BPH asks why his PSA dropped from 4.2 to 2.1 ng/mL
after 6 months. What should you tell him?
• A) Finasteride causes false-negative PSA; multiply result by 2
• B) He likely has prostate cancer
• C) Finasteride elevates PSA artificially
• D) The medication is not working
Answer: A
Rationale: Finasteride reduces PSA by ~50% by decreasing prostate volume. For cancer
screening, double the PSA value while on finasteride.
4. Acute bacterial prostatitis is most commonly caused by:
• A) Chlamydia trachomatis
• B) Escherichia coli
• C) Staphylococcus saprophyticus
• D) Neisseria gonorrhoeae
Answer: B
Rationale: E. coli accounts for 75–80% of acute bacterial prostatitis. Sexually transmitted
pathogens are rare in acute prostatitis but common in younger men with urethritis.
5. Which finding on DRE is most suggestive of prostate cancer?
• A) Boggy, tender gland
• B) Symmetric smooth enlargement
• C) Hard, irregular nodule
• D) Warmth and fluctuance
Answer: C
Rationale: Prostate cancer typically presents as a hard, non-tender, irregular nodule, often in
the peripheral zone. BPH is symmetric; prostatitis is tender/boggy.
6–25 (Abbreviated for length – full set continues similarly; here is a representative sample of
remaining prostate questions:)
6. Gold standard for diagnosing prostate cancer:
• Answer: C) Transrectal ultrasound-guided biopsy (Rationale: Biopsy is definitive; MRI
is adjunctive.)
7. Most common site of prostate cancer metastasis:
William Peterson University100/100(verified
Answers)
Section 1: Prostate Disorders (Questions 1–25)
1. A 58-year-old man presents with nocturia, hesitancy, and a weak stream. DRE reveals a
symmetrically enlarged, firm, non-tender prostate. PSA is 2.8 ng/mL. What is the most likely
diagnosis?
• A) Prostate cancer
• B) Acute bacterial prostatitis
• C) Benign prostatic hyperplasia (BPH)
• D) Chronic pelvic pain syndrome
Answer: C
Rationale: BPH typically presents with lower urinary tract symptoms (LUTS) and a
symmetrically enlarged prostate without tenderness. PSA is often normal or mildly elevated
(age-specific). Cancer is often asymmetrical or nodular; prostatitis would be tender.
2. Which medication class is first-line for moderate-to-severe BPH with bothersome LUTS?
• A) 5-alpha-reductase inhibitors
• B) Alpha-1 adrenergic antagonists
• C) Anticholinergics
• D) Phosphodiesterase-5 inhibitors
Answer: B
Rationale: Alpha-blockers (tamsulosin, alfuzosin) relax prostate smooth muscle, improving
flow quickly. 5-ARIs (finasteride) reduce prostate size but take months. PDE5Is are off-label
for LUTS.
, 3. A 72-year-old man on finasteride for BPH asks why his PSA dropped from 4.2 to 2.1 ng/mL
after 6 months. What should you tell him?
• A) Finasteride causes false-negative PSA; multiply result by 2
• B) He likely has prostate cancer
• C) Finasteride elevates PSA artificially
• D) The medication is not working
Answer: A
Rationale: Finasteride reduces PSA by ~50% by decreasing prostate volume. For cancer
screening, double the PSA value while on finasteride.
4. Acute bacterial prostatitis is most commonly caused by:
• A) Chlamydia trachomatis
• B) Escherichia coli
• C) Staphylococcus saprophyticus
• D) Neisseria gonorrhoeae
Answer: B
Rationale: E. coli accounts for 75–80% of acute bacterial prostatitis. Sexually transmitted
pathogens are rare in acute prostatitis but common in younger men with urethritis.
5. Which finding on DRE is most suggestive of prostate cancer?
• A) Boggy, tender gland
• B) Symmetric smooth enlargement
• C) Hard, irregular nodule
• D) Warmth and fluctuance
Answer: C
Rationale: Prostate cancer typically presents as a hard, non-tender, irregular nodule, often in
the peripheral zone. BPH is symmetric; prostatitis is tender/boggy.
6–25 (Abbreviated for length – full set continues similarly; here is a representative sample of
remaining prostate questions:)
6. Gold standard for diagnosing prostate cancer:
• Answer: C) Transrectal ultrasound-guided biopsy (Rationale: Biopsy is definitive; MRI
is adjunctive.)
7. Most common site of prostate cancer metastasis:
