Exam Practice Questions And Correct
Answers (Verified Answers) Plus Rationales
2026 Q&A | Instant Download Pdf
1. Which of the following best describes Type 1 diabetes?
a) Autoimmune destruction of pancreatic beta cells
b) Insulin resistance with relative insulin deficiency
c) Impaired glucose tolerance only
d) Secondary to other conditions
Answer: a) Autoimmune destruction of pancreatic beta cells
Rationale: Type 1 diabetes is caused by autoimmune destruction of
pancreatic beta cells, leading to absolute insulin deficiency.
2. The main pathophysiological defect in Type 2 diabetes is:
a) Autoimmunity
b) Insulin resistance and beta-cell dysfunction
c) Lack of glucagon
, d) Viral infection
Answer: b) Insulin resistance and beta-cell dysfunction
Rationale: Type 2 diabetes involves insulin resistance in tissues along
with progressive beta-cell dysfunction.
3. Which test is the gold standard for diagnosing diabetes?
a) Random blood glucose
b) Fasting plasma glucose
c) Oral glucose tolerance test (OGTT)
d) HbA1c
Answer: c) Oral glucose tolerance test (OGTT)
Rationale: OGTT is the most sensitive diagnostic test for diabetes,
though HbA1c and fasting plasma glucose are also used in practice.
4. The recommended HbA1c target for most adults with diabetes is:
a) <8.0%
b) <7.0%
c) <6.0%
d) <7.5%
Answer: b) <7.0%
Rationale: Guidelines recommend aiming for HbA1c <7.0% for most
adults, balancing benefits and hypoglycemia risk.
5. Which of the following is a rapid-acting insulin?
a) NPH
b) Regular insulin
, c) Insulin glargine
d) Insulin lispro
Answer: d) Insulin lispro
Rationale: Insulin lispro is a rapid-acting analog, while NPH is
intermediate, glargine is long-acting, and regular is short-acting.
6. Which oral diabetes medication primarily works by decreasing hepatic
glucose production?
a) Sulfonylureas
b) Metformin
c) DPP-4 inhibitors
d) SGLT2 inhibitors
Answer: b) Metformin
Rationale: Metformin lowers hepatic glucose production and improves
insulin sensitivity.
7. Which lifestyle intervention has the greatest impact on glycemic
control in Type 2 diabetes?
a) Reducing sodium intake
b) Weight management and physical activity
c) Vitamin supplementation
d) Increased water intake
Answer: b) Weight management and physical activity
Rationale: Weight loss and regular exercise significantly improve
insulin sensitivity and glycemic control.
, 8. What is the recommended carbohydrate distribution for a person with
diabetes?
a) All carbohydrates at breakfast
b) Spread evenly throughout meals and snacks
c) Avoid carbohydrates completely
d) Carbohydrates only at dinner
Answer: b) Spread evenly throughout meals and snacks
Rationale: Even distribution helps prevent postprandial hyperglycemia
and supports stable blood glucose control.
9. Which of the following is a sign of hypoglycemia?
a) Polyuria
b) Polydipsia
c) Sweating and tremors
d) Blurred vision over weeks
Answer: c) Sweating and tremors
Rationale: Hypoglycemia often presents with adrenergic symptoms
such as sweating, tremors, palpitations, and anxiety.
10. The recommended target for fasting plasma glucose in most
adults with diabetes is:
a) 3–5 mmol/L
b) 4–7 mmol/L
c) 5–9 mmol/L
d) 6–10 mmol/L