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statements
The Science of Lactation: Breastfeeding Physiology & Milk Production
Q1: The hormone primarily responsible for milk synthesis is:
A. Oxytocin
B. Prolactin [CORRECT]
C. Estrogen
D. Progesterone
Correct Answer: B
Rationale: Prolactin stimulates milk production in the alveoli (milk-producing cells).
Oxytocin triggers milk ejection (let-down), while estrogen and progesterone actually
inhibit lactation during pregnancy—progesterone drops after placental delivery to initiate
milk production.
Q2: Oxytocin is responsible for:
A. Stimulating alveolar milk production
,B. Triggering the milk ejection reflex (let-down) [CORRECT]
C. Preventing milk synthesis during pregnancy
D. Inhibiting uterine contractions after birth
Correct Answer: B
Rationale: Oxytocin causes myoepithelial cells around alveoli to contract, pushing milk
into the ducts (let-down). It also causes postpartum uterine cramping during
breastfeeding. Prolactin handles production; progesterone inhibits production during
pregnancy.
Q3: Lactogenesis Stage I refers to:
A. The first 24 hours after birth when colostrum is produced
B. The synthesis of colostrum during late pregnancy [CORRECT]
C. The onset of copious milk production around day 3-5
D. The establishment of mature milk supply after day 14
Correct Answer: B
Rationale: Lactogenesis I begins around 16-20 weeks gestation—mammary glands
produce colostrum during pregnancy. Stage II is copious milk onset (days 3-5
postpartum), and Stage III is mature milk maintenance (after day 14). The first 24 hours
involves colostrum feeding, not the physiological stage definition.
Q4: Lactogenesis Stage II typically begins:
A. Immediately after delivery
,B. Around 30-72 hours postpartum when progesterone drops [CORRECT]
C. At 6 weeks postpartum
D. Only after the first formula supplementation
Correct Answer: B
Rationale: Stage II (copious milk production) is triggered by progesterone withdrawal
following placental delivery, typically 30-72 hours postpartum. This "milk coming in" can
be delayed by retained placental fragments, C-section, or diabetes. It's not immediate,
not at 6 weeks, and doesn't require formula.
Q5: Colostrum is characterized by:
A. High fat content and low protein
B. Rich in immunoglobulins (IgA), protein, and low fat [CORRECT]
C. Identical composition to mature milk
D. Production only after day 5
Correct Answer: B
Rationale: Colostrum (days 1-5) is concentrated with IgA antibodies, lactoferrin, white
blood cells, and protein for immune protection. It's lower volume (10-20 mL/feeding)
and lower fat than mature milk. Transitional milk (days 5-14) gradually changes to
mature milk composition.
Q6: Transitional milk is produced:
A. Only during the first 24 hours after birth
, B. Between days 5-14 as milk composition changes [CORRECT]
C. After 6 months of breastfeeding
D. During pregnancy only
Correct Answer: B
Rationale: Transitional milk bridges colostrum and mature milk, with changing
immunoglobulin, fat, and lactose levels. Mature milk is established after day 14.
"Transitional" describes this 5-14 day window, not early colostrum, pregnancy, or late
breastfeeding.
Q7: Mature milk is established:
A. Within 6 hours of birth
B. By day 3-5 postpartum
C. After day 14 [CORRECT]
D. Only after solid foods are introduced
Correct Answer: C
Rationale: Mature milk (Stage III lactogenesis) is established after day 14, with
consistent composition of approximately 87% water, 7% lactose, 4% fat, and 1% protein.
Day 3-5 is transitional milk onset; 6 hours is colostrum; solids don't affect milk
maturation.
Q8: The difference between foremilk and hindmilk refers to:
A. Different types of milk produced at different times of day