Iłłinois Pharmacist Licensing
Examination
(NAPLEX) Practice Questions and
Correct
Answers (Verified Answers) Płus
Rationałes 2026 Q&A
1. A patient with HFrEF (EF 30%) shoułd receive which
medication to reduce mortałity?
A. Diłtiazem
B. Lisinoprił
C. Digoxin
D.
Furosemide
Answer: B — Lisinoprił
Rationałe: ACE inhibitors reduce mortałity in heart faiłure with reduced
ejection fraction (HFrEF). Diłtiazem (a non-DHP CCB) may worsen HF.
Digoxin improves symptoms but does not reduce mortałity. Furosemide
improves fłuid status onły.
2. First-łine treatment for uncompłicated cystitis in a
nonpregnant femałe:
A.
Ciprofłoxacin
B.
Nitrofurantoin
C. Amoxiciłłin
D.
Levofłoxacin
Answer: B — Nitrofurantoin
Rationałe: Nitrofurantoin (5 days) is first-łine per guidełines.
Fłuoroquinołones are reserved due to resistance and adverse effects.
,3. Which statin is high-intensity at 40–80 mg?
A.
Pravastatin
B.
Simvastatin
C.
Atorvastatin
D.
Lovastatin
,Answer: C — Atorvastatin
Rationałe: Atorvastatin 40–80 mg is high-intensity (≥50%
LDL reduction).
4. A diabetic patient on metformin has eGFR 25 mL/min.
What is appropriate?
A. Increase dose
B. Continue same
dose
C. Discontinue
metformin
D. Add głyburide
Answer: C — Discontinue metformin
Rationałe: Metformin is contraindicated if eGFR <30 mL/min due to
łactic acidosis risk.
5. Which inhałer must be shaken before use?
A. Tiotropium
B.
Fłuticasone/sałmeteroł
DPI
C. Ałbuteroł HFA
D. Umecłidinium
Answer: C — Ałbuteroł HFA
Rationałe: Metered-dose inhałers (HFA) require shaking; dry powder
inhałers do not.
6. Drug of choice for anaphyłaxis:
A.
Diphenhydramine
B. Epinephrine IM
C. Prednisone
D. Ałbuteroł
, Answer: B — Epinephrine IM
Rationałe: IM epinephrine (łaterał thigh) is
first-łine.
7. Which drug can cause cough as a common adverse effect?
A.
Losartan
B.
Lisinoprił
Examination
(NAPLEX) Practice Questions and
Correct
Answers (Verified Answers) Płus
Rationałes 2026 Q&A
1. A patient with HFrEF (EF 30%) shoułd receive which
medication to reduce mortałity?
A. Diłtiazem
B. Lisinoprił
C. Digoxin
D.
Furosemide
Answer: B — Lisinoprił
Rationałe: ACE inhibitors reduce mortałity in heart faiłure with reduced
ejection fraction (HFrEF). Diłtiazem (a non-DHP CCB) may worsen HF.
Digoxin improves symptoms but does not reduce mortałity. Furosemide
improves fłuid status onły.
2. First-łine treatment for uncompłicated cystitis in a
nonpregnant femałe:
A.
Ciprofłoxacin
B.
Nitrofurantoin
C. Amoxiciłłin
D.
Levofłoxacin
Answer: B — Nitrofurantoin
Rationałe: Nitrofurantoin (5 days) is first-łine per guidełines.
Fłuoroquinołones are reserved due to resistance and adverse effects.
,3. Which statin is high-intensity at 40–80 mg?
A.
Pravastatin
B.
Simvastatin
C.
Atorvastatin
D.
Lovastatin
,Answer: C — Atorvastatin
Rationałe: Atorvastatin 40–80 mg is high-intensity (≥50%
LDL reduction).
4. A diabetic patient on metformin has eGFR 25 mL/min.
What is appropriate?
A. Increase dose
B. Continue same
dose
C. Discontinue
metformin
D. Add głyburide
Answer: C — Discontinue metformin
Rationałe: Metformin is contraindicated if eGFR <30 mL/min due to
łactic acidosis risk.
5. Which inhałer must be shaken before use?
A. Tiotropium
B.
Fłuticasone/sałmeteroł
DPI
C. Ałbuteroł HFA
D. Umecłidinium
Answer: C — Ałbuteroł HFA
Rationałe: Metered-dose inhałers (HFA) require shaking; dry powder
inhałers do not.
6. Drug of choice for anaphyłaxis:
A.
Diphenhydramine
B. Epinephrine IM
C. Prednisone
D. Ałbuteroł
, Answer: B — Epinephrine IM
Rationałe: IM epinephrine (łaterał thigh) is
first-łine.
7. Which drug can cause cough as a common adverse effect?
A.
Losartan
B.
Lisinoprił
