COMAT FBS: Key Medical Concepts and Mechanisms
Exam Coverage
Exam coverage for the COMAT FBS: Key Medical Concepts and
Mechanisms includes foundational biomedical science principles used
in osteopathic medical education. It focuses on core concepts in
human physiology, pathophysiology, biochemistry, and
pharmacologic mechanisms, including cellular function, organ system
interactions, and homeostatic regulation. The exam also evaluates
understanding of disease mechanisms, inflammatory and immune
responses, metabolic pathways, and the effects of drugs on
physiological systems.
,allergic rhinitis early reaction
w/in 30min, type I HS
allergic rhinitis pathophysiology
APCs (dendritics) at mucosal surfaces present peptides from allergens
to MHC-II = ligand for naive CD4 = Th2 activation and cytokine
secretion / B cell isotype switching = IgE and eosino/mast/neutro
proliferation
allergic rhinitis late reaction
w/in 6hr
,anaphylaxis mechanism
first exposure = IgE Abs
hypersensitivity types
1. IgE-mediated (allergies, asthma, anaphylaxis) 2. Cytotoxic
ANTIBODY-mediated (IgM, IgG) (bullous pemphigoid, autoimmune
hemolytic anemia, good pasture) 3. Immune COMPLEX-mediated (Ag-
Ab) (SLE, arthus reaction, serums sickness) 4. Delayed-type T cell/MQ-
mediated (allergic contact dermatitis , TB, transplant rejection)
, autoimmune RECEPTOR-mediated (IgM, IgG)
anemia mechanism via blood loss that causes iron deficiency,
hemolysis, or reduced erythropoiesis
hypochromic microcytic anemia associated conditions
iron deficiency anemia, thalassemia MINOR (only abn is Hb
electrophoresis), lead poisoning (prominent basophilic stippling),
chronic infection
iron deficiency anemia
hypochromic microcytic, 'cigar cells'
Exam Coverage
Exam coverage for the COMAT FBS: Key Medical Concepts and
Mechanisms includes foundational biomedical science principles used
in osteopathic medical education. It focuses on core concepts in
human physiology, pathophysiology, biochemistry, and
pharmacologic mechanisms, including cellular function, organ system
interactions, and homeostatic regulation. The exam also evaluates
understanding of disease mechanisms, inflammatory and immune
responses, metabolic pathways, and the effects of drugs on
physiological systems.
,allergic rhinitis early reaction
w/in 30min, type I HS
allergic rhinitis pathophysiology
APCs (dendritics) at mucosal surfaces present peptides from allergens
to MHC-II = ligand for naive CD4 = Th2 activation and cytokine
secretion / B cell isotype switching = IgE and eosino/mast/neutro
proliferation
allergic rhinitis late reaction
w/in 6hr
,anaphylaxis mechanism
first exposure = IgE Abs
hypersensitivity types
1. IgE-mediated (allergies, asthma, anaphylaxis) 2. Cytotoxic
ANTIBODY-mediated (IgM, IgG) (bullous pemphigoid, autoimmune
hemolytic anemia, good pasture) 3. Immune COMPLEX-mediated (Ag-
Ab) (SLE, arthus reaction, serums sickness) 4. Delayed-type T cell/MQ-
mediated (allergic contact dermatitis , TB, transplant rejection)
, autoimmune RECEPTOR-mediated (IgM, IgG)
anemia mechanism via blood loss that causes iron deficiency,
hemolysis, or reduced erythropoiesis
hypochromic microcytic anemia associated conditions
iron deficiency anemia, thalassemia MINOR (only abn is Hb
electrophoresis), lead poisoning (prominent basophilic stippling),
chronic infection
iron deficiency anemia
hypochromic microcytic, 'cigar cells'
