PAT 201- Week 3: Inflammation
What is inflammation? - correct answer✔ ✔ A non-specific response
to injury that destroys agents that could damage tissue. Central purpose
is to contain the injury or destroy the foreign agent. Responds to injury
to vascularized tissue!
What is the second line of defence in innate immunity and what does it
do? - correct answer✔ ✔ - INFLAMMATION
- Reacts to mechanical damage, ischemia, nutrient deprivation, radiation
- Cellular and chemical components
- Nonspecific and rapidly initiated, with no memory cells
What are the 4 cardinal signs of inflammation? - correct answer✔ ✔
redness, heat, swelling, pain (sometimes loss of function)
What is the vascular response in the second line of defence? - correct
answer✔ ✔ - Blood vessel dilation
- Increased vascular permeability and leakage
- WBC adherence to inner walls of vessels and migration through
vessels
, What do mast cells do and how does it affect blood vessels? - correct
answer✔ ✔ - Release histamine
- Endothelial cells contract
- Vasodilation
- Vascular permeability increases
What happens when injury occurs to endothelial cells? - correct answer
✔ ✔ WBC receptors sprout (endothelial adhesion molecule)
What do the plasma protein systems do? - correct answer✔ ✔ - Offer
a biological barrier against pathogens
- Are finely regulated and can be activated or inactivated
- All contain enzymes called proenzymes, which are converted to active
enzymes
- Sequentially activated
- Complement, clotting, kinin
What do carboxypeptidase, histaminase, arysulfatase, kinase, and C1-
esterase inhibitor do? - correct answer✔ ✔ Carboxypeptidase:
inhibits C3a and C5a
Histaminase: inhibits histamine
Arylsulfatase: inhibits histamine
What is inflammation? - correct answer✔ ✔ A non-specific response
to injury that destroys agents that could damage tissue. Central purpose
is to contain the injury or destroy the foreign agent. Responds to injury
to vascularized tissue!
What is the second line of defence in innate immunity and what does it
do? - correct answer✔ ✔ - INFLAMMATION
- Reacts to mechanical damage, ischemia, nutrient deprivation, radiation
- Cellular and chemical components
- Nonspecific and rapidly initiated, with no memory cells
What are the 4 cardinal signs of inflammation? - correct answer✔ ✔
redness, heat, swelling, pain (sometimes loss of function)
What is the vascular response in the second line of defence? - correct
answer✔ ✔ - Blood vessel dilation
- Increased vascular permeability and leakage
- WBC adherence to inner walls of vessels and migration through
vessels
, What do mast cells do and how does it affect blood vessels? - correct
answer✔ ✔ - Release histamine
- Endothelial cells contract
- Vasodilation
- Vascular permeability increases
What happens when injury occurs to endothelial cells? - correct answer
✔ ✔ WBC receptors sprout (endothelial adhesion molecule)
What do the plasma protein systems do? - correct answer✔ ✔ - Offer
a biological barrier against pathogens
- Are finely regulated and can be activated or inactivated
- All contain enzymes called proenzymes, which are converted to active
enzymes
- Sequentially activated
- Complement, clotting, kinin
What do carboxypeptidase, histaminase, arysulfatase, kinase, and C1-
esterase inhibitor do? - correct answer✔ ✔ Carboxypeptidase:
inhibits C3a and C5a
Histaminase: inhibits histamine
Arylsulfatase: inhibits histamine
