Test Bank For Cellular and Molecular Immunology, 11th Edition by Abul K. Abbas| Verified Chapters 1-21|| Latest Edition 2025

,Table of Contents
+z +z




Chapter 01 Properties and Overview of Immune Responses
+z +z +z +z +z +z +z 1
Chapter 02 Cells and Tissues of the Immune System
+z +z +z +z +z +z +z +z 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
+z +z +z +z +z +z +z 6
Chapter 04 Innate Immunity
+z +z +z 10
Chapter 05 Antibodies and Antigens
+z +z +z +z 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
+z +z +z +z +z +z +z +z +z +z +z



Histocompatibility Complex Molecules
+z +z 20
Chapter 07 Immune Receptors and Signal Transduction
+z +z +z +z +z +z 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
+z +z +z +z +z +z +z +z 30
Chapter 09 Activation of T Lymphocytes
+z +z +z +z +z 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
+z +z +z +z +z +z +z +z +z 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
+z +z +z +z +z +z +z +z +z 42
Chapter 12 B Cell Activation and Antibody Production
+z +z +z +z +z +z +z 46
Chapter 13 Effector Mechanisms of Humoral Immunity
+z +z +z +z +z +z 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
+z +z +z +z +z +z +z +z +z +z +z 56
Chapter 15 Immunologic Tolerance and Autoimmunity
+z +z +z +z +z 62
Chapter 16 Immunity to Microbes
+z +z +z +z 67
Chapter 17 Transplantation Immunology
+z +z +z 72
Chapter+z 18 +z Tumor Immunology
+z 77
Chapter+z 19 +z Hypersensitivity Disorders +z 81
Chapter+z 20 +z Allergy 86
Chapter+z 21 +z Primary and Acquired Immunodeficiencies
+z +z +z 89

,Chapter 01: Properties and Overview of Immune Responses
+z +z +z +z +z +z +z


Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 11th Edition
+z +z +z +z +z +z +z +z +z




MULTIPLE CHOICE +z




1. The principal function of the immune system is:
+z +z +z +z +z +z +z


a. Defense against cancer +z +z


b. Repair of injured tissues +z +z +z


c. Defense against microbial infections +z +z +z


d. Prevention of inflammatory diseases +z +z +z


e. Protection against environmental toxins +z +z +z




ANS: C + z


The immune system has evolved in the setting of selective pressures imposed by microbi
+z +z +z +z +z +z +z +z +z +z +z +z +z


al infections. Although immune responses to cancer may occur, the concept that “immun
+z +z +z +z +z +z +z +z +z +z +z +z


osurveillance” against cancer is a principal function of the immune system is controversi
+z +z +z +z +z +z +z +z +z +z +z +z


al. Repair of injured tissues may be a secondary consequence of the immune responses a
+z +z +z +z +z +z +z +z +z +z +z +z +z +z


nd inflammation. Although the immune system has regulatory features that are needed to
+z +z +z +z +z +z +z +z +z +z +z +z


prevent excessive inflammation, prevention of inflammatory diseases is not a primary fu
+z +z +z +z +z +z +z +z +z +z +z +z


nction. The immune system can protect against microbial toxins, but it generally does not
+z +z +z +z +z +z +z +z +z +z +z +z +z +


offer protection against toxins of nonbiologic origin.
z +z +z +z +z +z +z




2. Which of the following infectious diseases was prevented by the first successf
+z +z +z +z +z +z +z +z +z +z +z


ul vaccination?
+z


a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C + z


In 1798, Edward Jenner reported the first intentional successful vaccination, which was
+z +z +z +z +z +z +z +z +z +z +z +z


against smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 198
+z +z +z +z +z +z +z +z +z +z +z +z +z +z +z


0, smallpox was reported to be eradicated worldwide by a vaccination program. Effectiv
+z +z +z +z +z +z +z +z +z +z +z +z


e vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th
+z +z +z +z +z +z +z +z +z +z +z +z +z


century and are widely used. There is no effective vaccine against Mycobacterium tuber
+z +z +z +z +z +z +z +z +z +z +z +z +z


culosis.

3. Which of the following is a unique property of the adaptive immune system?
+z +z +z +z +z +z +z +z +z +z +z +z


a. Highly diverse repertoire of specificities for antigens
+z +z +z +z +z +z


b. Self-nonself discrimination +z


c. Recognition of microbial structures by both cell-associated and soluble receptors
+z +z +z +z +z +z +z +z +z


d. Protection against viral infections +z +z +z


e. Responses that have the same kinetics and magnitude on repeated exposure to t
+z +z +z +z +z +z +z +z +z +z +z +z


he same microbe +z +z




ANS: + z A

, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
+z +z +z +z +z +z +z +z +z +z +z +z +z +z


cytes, which are the central cellular components of the adaptive immune system. Both th
+z +z +z +z +z +z +z +z +z +z +z +z +z


e innate and the adaptive immune systems use cell-
+z +z +z +z +z +z +z +z


associated and soluble receptors to recognize microbes, display some degree of self-
+z +z +z +z +z +z +z +z +z +z +z


nonself discrimination, and protect against viruses. On repeated exposure to the same mi
+z +z +z +z +z +z +z +z +z +z +z +z


crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
+z +z +z +z +z +z +z +z +z +z +z +z +


is the manifestation of memory.
z +z +z +z +z




4. Antibodies and T lymphocytes are the respective mediators of which two types
+z +z +z +z +z +z +z +z +z +z +z +z


of immunity?
+z


a. Innate and adaptive +z +z


b. Passive and active +z +z


c. Specific and nonspecific +z +z


d. Humoral and cell-mediated +z +z


e. Adult and neonatal +z +z




ANS: D + z


Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
+z +z +z +z +z +z +z +z +z +z +z +z


s produce antibodies, which are the recognition and effector molecules of humoral immun
+z +z +z +z +z +z +z +z +z +z +z +z


e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
+z +z +z +z +z +z +z +z +z +z +z +z


ellular pathogens in cell- +z +z +z


mediated immunity. Passive and active immunity both can be mediated by either B or T ly
+z +z +z +z +z +z +z +z +z +z +z +z +z +z +z


mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp
+z +z +z +z +z +z +z +z +z +z +z +z +z


hocytes participate in adult adaptive immunity but are still developing in the neonatal peri
+z +z +z +z +z +z +z +z +z +z +z +z +z


od.

5. The two major functional classes of effector T lymphocytes are:
+z +z +z +z +z +z +z +z +z


a. Helper T lymphocytes and cytotoxic T lymphocytes
+z +z +z +z +z +z


b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
+z +z +z +z


c. Memory T cells and effector T cells +z +z +z +z +z +z


d. Helper cells and antigen-presenting cells +z +z +z +z


e. Cytotoxic T lymphocytes and target cells +z +z +z +z +z




ANS: A + z


T cells can be classified into effector subsets that perform different effector functions. Mo
+z +z +z +z +z +z +z +z +z +z +z +z +z


st effector T cells are either helper T lymphocytes, which enhance the responses of other
+z +z +z +z +z +z +z +z +z +z +z +z +z +z


immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt
+z +z +z +z +z +z +z +z +z +z +z +z +z


es, which directly kill infected cells. Natural killer cells are not T lymphocytes.
+z +z +z +z +z +z +z +z +z +z +z +z


Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. +z +z +z +z +z +z +z +z +z +z +z +z +z +z




6. Which of the following cell types is required for all adaptive humoral immune responses?
+z +z +z +z +z +z +z +z +z +z +z +z +z


a. Natural killer cells +z +z


b. Dendritic cells +z


c. Cytolytic T lymphocytes +z +z


d. B lymphocytes +z


e. Helper T lymphocytes +z +z




ANS: D + z


Humoral immune responses are antibody- +z +z +z +z


mediated immune responses, and all antibodies are made by B lymphocytes and no oth
+z +z +z +z +z +z +z +z +z +z +z +z +z


er cell type.
+z +z